Human IL-4R alpha Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: IL-4R alpha

Interleukin 4 (IL‑4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. The biological functions of IL‑4 are mediated by the binding of IL‑4 to high‑affinity cell surface receptor complexes. Two types of IL‑4 receptor complexes have been described. The type I IL‑4 receptor complex is composed of a high‑affinity IL‑4‑binding subunit (referred to as IL‑4 R alpha ) and the common gamma chain that does not bind IL‑4 by itself. The type II IL‑4 receptor complex is composed of IL‑4 R alpha and IL‑13 R alpha 1. Besides IL‑4 signals, the type II IL‑4 receptor complex can also transduce IL‑13 signals. In the type II complex, the IL‑4 R alpha subunit binds only IL‑4 and not IL‑13. Similarly, the IL‑13 R alpha 1 subunit binds only IL‑13 and not IL‑4. The cDNA clones for both the human and mouse IL‑4 R alpha have been isolated and shown to encode an approximately 140 kDa type I transmembrane protein with a large cytoplasmic domain that is essential for signal transduction. In mouse cells, an alternatively spliced variant encoding a soluble secreted IL‑4 R alpha isoform has also been identified. Naturally occurring soluble IL‑4 R alpha that binds IL‑4 with high‑affinity has been found in mouse and human biological fluids.

Product Datasheets

Related Research Areas

• B Cell Activation
• B Cell Markers
• Common gamma Chain Receptor Family
• Cytokines and Receptors in Allergy and Asthma
• Cytokines and Receptors in Angiogenesis
• Cytokines and Receptors in Tfh Cell Differentiation and Function
• Macrophage Activation Markers
• Myeloid-derived Suppressor Cells (MDSC)
• Receptors in the Jak/STAT Pathway
• Regulatory T Cells (Tregs)
• T Cell Cytokine Signaling
• Th17 Cells
• Th2 Cells
• Th9 Cells