Human Integrin  beta 7 Biotinylated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: Integrin beta 7

Human Integrin beta 7 (also Integrin beta P and M290 IEL Ag) is a 120 kDa member of the Integrin beta chain family of molecules. It is a type I transmembrane glycoprotein that contains a 704 amino acid (aa) extracellular domain (ECD) (aa 20-723) and a 52 aa cytoplasmic tail. The ECD contains one von Willebrand factor A domain (aa 150-389) and four cysteine-rich EGF-like repeats. One splice variant exists that shows a deletion of aa 501-648. Integrin  beta 7 forms a nondisulfide linked heterodimer with  alpha 4 and  alpha E integrins. alpha 4 beta 7 binds fibronectin, VCAM-1, and MADCAM1, while alpha E beta 7 binds E-cadherin. The ECD of human  beta 7 is 87% aa identical to the ECD of mouse  beta 7.

Product Datasheets

Related Research Areas

• Acute Lymphoblastic Leukemia
• Adhesion Molecules
• Adhesion Molecules in Angiogenesis
• Adhesion Molecules on VSMC
• Adhesive Interactions in Allergy and Asthma
• Integrins and Associated Molecules