Human/Mouse CXCL12/SDF-1 Antibody Summary
Lys22-Lys89
Accession # Q6ICW0
Applications
Human/Mouse CXCL12/SDF-1 Sandwich Immunoassay
Human CXCL12/SDF-1 beta Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
CXCL12/SDF‑1 in Human PBMCs and K562 Human Cell Line. CXCL12/SDF-1 was detected in immersion fixed human peripheral blood mononuclear cells (PBMCs; positive staining) and K562 human chronic myelogenous leukemia cell line (negative staining) using Mouse Anti-Human/Mouse CXCL12/SDF-1 Monoclonal Antibody (Catalog # MAB350) at 8 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counterstained with DAPI (blue). Specific staining was localized to cell membranes. View our protocol for Fluorescent ICC Staining of Non-adherent Cells.
CXCL12/SDF‑1 in Human Tonsil. CXCL12/SDF‑1 was detected in immersion fixed paraffin-embedded sections of human tonsil using 15 µg/mL Human/Mouse CXCL12/SDF‑1 Monoclonal Antibody (Catalog # MAB350) overnight at 4 °C. Tissue was stained with the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific labeling was localized to epithelial cells in cripts. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
CXCL12/SDF‑1 in Human Tonsil. CXCL12/SDF‑1 was detected in immersion fixed paraffin-embedded sections of human tonsil using Human/Mouse CXCL12/SDF‑1 Monoclonal Antibody (Catalog # MAB350) at 25 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Detection of CXCL12/SDF‑1 in HT1080 Human Cell Line by Flow Cytometry. HT1080 human fibrosarcoma cell line was stained with Mouse Anti-Human/Mouse CXCL12/SDF-1 Monoclonal Antibody (Catalog # MAB350, filled histogram) or isotype control antibody (Catalog # MAB002, open histogram), followed by Phycoerythrin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0102B). To facilitate intracellular staining, cells were fixed and permeabilized with FlowX FoxP3 Fixation & Permeabilization Buffer Kit (Catalog # FC012). View our protocol for Staining Intracellular Molecules.
CXCL12/SDF‑1 alpha in Human Tonsil Using Dual RNAscope®ISH and IHC. CXCL12/SDF-1a mRNA was detected in formalin-fixed paraffin-embedded tissue sections of human tonsil probed with ACD RNAScope®Probe (Catalog # 422991) and stained using ACD RNAscope®2.5 HD Detection Reagents-Red (top image, Catalog # 32260). Adjacent tissue section was processed for immunohistochemistry using R&D Systems Mouse Anti-Human CXCL12/SDF-1a Monoclonal Antibody (Catalog # MAB350) at 5 ug/mL for 1 hour at room temperature followed by incubation with the Anti-Mouse IgG VisUCyte HRP Polymer Antibody (R&D Systems, Catalog # VC001) and DAB chromogen (lower image, yellow-brown). Tissues were counterstained with hematoxylin (blue).
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: CXCL12/SDF-1
CXCL12, also known as SDF-1, is a CXC chemokine that interacts with CXCR4. SDF-1 alpha and SDF-1 beta are alternatively spliced isoforms of CXCL12. SDF-1 beta has an additional 4 amino acids at the carboxy-terminus.
Product Datasheets
Citations for Human/Mouse CXCL12/SDF-1 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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CXCL12 Neutralizing Antibody Promotes Hair Growth in Androgenic Alopecia and Alopecia Areata
Authors: Zheng, M;Kim, MH;Park, SG;Kim, WS;Oh, SH;Sung, JH;
International journal of molecular sciences
Species: Murine polyomavirus strain A3
Sample Types: Whole Tissue
Applications: Immunohistochemistry -
Novel characterization of CXCR4 expressing cells in uninfected and herpes simplex virus-1 infected corneas
Authors: PK Suvas, M Setia, M Rana, A Chakrabort, S Suvas
The ocular surface, 2023-02-20;28(0):99-107.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Molecular Profiling of Tissue Samples with Chronic Rejection from Patients with Chronic Lung Allograft Dysfunction: A Pilot Study in Cystic Fibrosis Patients
Authors: F Lunardi, DI Abbrescia, L Vedovelli, F Pezzuto, F Fortarezza, GM Comacchio, V Guzzardo, P Ferrigno, M Loy, C Giraudo, AS Fraia, E Faccioli, F Braccioni, E Cozzi, D Gregori, GM Verleden, F Calabrese, FP Schena, F Rea
Biomolecules, 2023-01-03;13(1):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Novel characterization of CXCR4 expressing cells in uninfected and herpes simplex virus-1 infected corneas
Authors: PK Suvas, M Setia, M Rana, A Chakrabort, S Suvas
The ocular surface, 2023;28(0):99-107.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
CXCR4-CXCL12-CXCR7 and PD-1/PD-L1 in Pancreatic Cancer: CXCL12 Predicts Survival of Radically Resected Patients
Authors: C D'Alterio, A Giardino, G Scognamigl, G Butturini, L Portella, G Guardascio, I Frigerio, M Montella, S Gobbo, G Martignoni, V Napolitano, F De Vita, F Tatangelo, R Franco, S Scala
Cells, 2022-10-22;11(21):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Meteorin links the bone marrow hypoxic state to hematopoietic stem/progenitor cell mobilization
Authors: YW Dai, JK Ma, R Jiang, XL Zhan, SY Chen, LL Feng, Q Zhang, TB Liang, K Lv, GJ Yang, JF Lu, J Chen, XJ Lu
Cell Reports, 2022-09-20;40(12):111361.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: ELISA Capture -
Peripheral apoE4 enhances Alzheimer's pathology and impairs cognition by compromising cerebrovascular function
Authors: CC Liu, J Zhao, Y Fu, Y Inoue, Y Ren, Y Chen, SV Doss, F Shue, S Jeevaratna, L Bastea, N Wang, YA Martens, W Qiao, M Wang, N Zhao, L Jia, Y Yamazaki, A Yamazaki, CL Rosenberg, Z Wang, D Kong, Z Li, LA Kuchenbeck, ZA Trottier, L Felton, J Rogers, ZS Quicksall, C Linares, J Knight, Y Chen, A Kurti, T Kanekiyo, JD Fryer, YW Asmann, P Storz, X Wang, J Peng, B Zhang, BYS Kim, G Bu
Nature Neuroscience, 2022-08-01;25(8):1020-1033.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression
Authors: II Verginadis, H Avgousti, J Monslow, G Skoufos, F Chinga, K Kim, NM Leli, IV Karagounis, BI Bell, A Velalopoul, CS Salinas, VS Wu, Y Li, J Ye, DA Scott, AL Osterman, A Sengupta, A Weljie, M Huang, D Zhang, Y Fan, E Radaelli, JW Tobias, F Rambow, P Karras, JC Marine, X Xu, AG Hatzigeorg, S Ryeom, JA Diehl, SY Fuchs, E Puré, C Koumenis
Nature Cell Biology, 2022-06-02;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Biological Role of Tumor/Stromal CXCR4-CXCL12-CXCR7 in MITO16A/MaNGO-OV2 Advanced Ovarian Cancer Patients
Authors: C D'Alterio, A Spina, L Arenare, P Chiodini, M Napolitano, F Galdiero, L Portella, V Simeon, S Signoriell, F Raspaglies, D Lorusso, C Pisano, N Colombo, GF Zannoni, NS Losito, R De Cecio, G Scognamigl, D Califano, D Russo, V Tuninetti, MC Piccirillo, P Gargiulo, F Perrone, S Pignata, S Scala
Cancers, 2022-04-06;14(7):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Preservation of the na�ve features of mesenchymal stromal cells in vitro: Comparison of cell- and bone-derived decellularized extracellular matrix
Authors: AR Pereira, D Trivanovi?, P Stahlhut, M Rudert, J Groll, M Herrmann
Journal of tissue engineering, 2022-02-07;13(0):2041731422107.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Cholinergic signals preserve haematopoietic stem cell quiescence during regenerative haematopoiesis
Authors: C Fielding, A García-Gar, C Korn, S Gadomski, Z Fang, JL Reguera, JA Pérez-Simó, B Göttgens, S Méndez-Fer
Nature Communications, 2022-01-27;13(1):543.
Species: Mouse
Sample Types: Bone Marrow Lavage Fluid
Applications: ELISA Capture -
Stimulated Expression of CXCL12 in Adrenocortical Carcinoma by the PPARgamma Ligand Rosiglitazone Impairs Cancer Progression
Authors: G Cantini, L Fei, L Canu, E Lazzeri, M Sottili, M Francalanc, ML Angelotti, G De Filpo, T Ercolino, S Gelmini, M Mangoni, G Nesi, C Hantel, M Mannelli, M Maggi, M Luconi
Journal of personalized medicine, 2021-10-27;11(11):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Microbiota-derived lactate promotes hematopoiesis and erythropoiesis by inducing stem cell factor production from leptin receptor+ niche cells
Authors: YS Lee, TY Kim, Y Kim, S Kim, SH Lee, SU Seo, BO Zhou, O Eunju, KS Kim, MN Kweon
Experimental & Molecular Medicine, 2021-09-09;0(0):.
Species: Mouse
Sample Types: Whole Cells, Whole Tissue
Applications: ICC, IHC -
Plasma cell dynamics in the bone marrow niche
Authors: Z Benet, Z Jing, DR Fooksman
Cell Reports, 2021-02-09;34(6):108733.
Species: Mouse
Sample Types: Whole Cells
Applications: ELISA Development -
CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response
Authors: D Biasci, M Smoragiewi, CM Connell, Z Wang, Y Gao, JED Thaventhir, B Basu, L Magiera, TI Johnson, L Bax, A Gopinathan, C Isherwood, FA Gallagher, M Pawula, I Hudecova, D Gale, N Rosenfeld, P Barmpounak, EC Popa, R Brais, E Godfrey, F Mir, FM Richards, DT Fearon, T Janowitz, DI Jodrell
Proc Natl Acad Sci U S A, 2020-10-30;0(0):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
New CXCR4 Antagonist Peptide R (Pep R) Improves Standard Therapy in Colorectal Cancer
Authors: C D'Alterio, A Zannetti, AM Trotta, C Ieranò, M Napolitano, G Rea, A Greco, P Maiolino, S Albanese, G Scognamigl, F Tatangelo, S Tafuto, L Portella, S Santagata, G Nasti, A Ottaiano, R Pacelli, P Delrio, G Botti, S Scala
Cancers (Basel), 2020-07-18;12(7):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Engineered scaffolds based on mesenchymal stem cells/preosteoclasts extracellular matrix promote bone regeneration
Authors: R Dong, Y Bai, J Dai, M Deng, C Zhao, Z Tian, F Zeng, W Liang, L Liu, S Dong
J Tissue Eng, 2020-06-07;11(0):2041731420926.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
SOX4 activates CXCL12 in hepatocellular carcinoma cells to modulate endothelial cell migration and angiogenesis in vivo
Authors: CN Tsai, SC Yu, CW Lee, JS Pang, CH Wu, SE Lin, YH Chung, CL Tsai, SY Hsieh, MC Yu
Oncogene, 2020-05-13;0(0):.
Species: Human
Sample Types:
Applications: Functional Assay -
The lymph node stromal laminin alpha 5 shapes alloimmunity
Authors: L Li, MW Shirkey, T Zhang, Y Xiong, W Piao, V Saxena, C Paluskievi, YS Lee, N Toney, BM Cerel, Q Li, T Simon, KD Smith, KL Hippen, BR Blazar, R Abdi, JS Bromberg
J. Clin. Invest., 2020-05-01;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Prognostic Value of SDF-1alpha Expression in Patients with Esophageal Squamous Cell Carcinoma Receiving Esophagectomy
Authors: YH Chen, SH Li, HI Lu, CM Lo
Cancers (Basel), 2020-04-25;12(5):.
Species: Human
Sample Types: Whole Cells, Whole Tissue
Applications: IHC, Neutralization -
Involvement of CXCL12/CXCR4 in the motility of human first-trimester endometrial epithelial cells through an autocrine mechanism by activating PI3K/AKT signaling
Authors: J Zheng, D Qu, C Wang, L Ding, W Zhou
BMC Pregnancy Childbirth, 2020-02-10;20(1):87.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Acetyl-L-Carnitine downregulates invasion (CXCR4/CXCL12, MMP-9) and angiogenesis (VEGF, CXCL8) pathways in prostate cancer cells: rationale for prevention and interception strategies
Authors: D Baci, A Bruno, C Cascini, M Gallazzi, L Mortara, F Sessa, G Pelosi, A Albini, DM Noonan
J. Exp. Clin. Cancer Res., 2019-11-12;38(1):464.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Paclitaxel-activated astrocytes produce mechanical allodynia in mice by releasing tumor necrosis factor-alpha and stromal-derived cell factor 1
Authors: X Liu, R Tonello, Y Ling, YJ Gao, T Berta
J Neuroinflammation, 2019-11-10;16(1):209.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Reduced RhoA expression enhances breast cancer metastasis with a concomitant increase in CCR5 and CXCR4 chemokines signaling
Authors: G Kalpana, C Figy, M Yeung, KC Yeung
Sci Rep, 2019-11-08;9(1):16351.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
The CXCR4-CXCL12-Axis Is of Prognostic Relevance in DLBCL and Its Antagonists Exert Pro-Apoptotic Effects In Vitro
Authors: K Pansy, J Feichtinge, B Ehall, B Uhl, M Sedej, D Roula, B Pursche, A Wolf, M Zoidl, E Steinbauer, V Gruber, HT Greinix, KT Prochazka, GG Thallinger, A Heinemann, C Beham-Schm, P Neumeister, TM Wrodnigg, K Fechter, AJ Deutsch
Int J Mol Sci, 2019-09-24;20(19):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Age-related differences in the bone marrow stem cell niche generate specialized microenvironments for the distinct regulation of normal hematopoietic and leukemia stem cells
Authors: GY Lee, SY Jeong, HR Lee, IH Oh
Sci Rep, 2019-01-30;9(1):1007.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
The Role of CXCL12 Axis in Lung Metastasis of Colorectal Cancer
Authors: M Wang, X Yang, M Wei, Z Wang
J Cancer, 2018-10-10;9(21):3898-3903.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Senescent fibroblasts drive ageing pigmentation: ?A potential therapeutic target for senile lentigo
Authors: JE Yoon, Y Kim, S Kwon, M Kim, YH Kim, JH Kim, TJ Park, HY Kang
Theranostics, 2018-09-09;8(17):4620-4632.
Species: Human
Sample Types: Whole Cells, Whole Tissue
Applications: ICC, IHC-P -
CXCR4 and its ligand CXCL12 display opposite expression profiles in feline mammary metastatic disease, with the exception of HER2-overexpressing tumors
Authors: CS Marques, AR Santos, A Gameiro, J Correia, F Ferreira
BMC Cancer, 2018-07-16;18(1):741.
Species: Feline
Sample Types: Whole Tissue
Applications: IHC -
CXCR4/CXCL12 Signaling and Protumor Macrophages in Primary Tumors and Sentinel Lymph Nodes Are Involved in Luminal B Breast Cancer Progression
Authors: C Raschioni, G Bottai, A Sagona, V Errico, A Testori, W Gatzemeier, F Corsi, C Tinterri, M Roncalli, L Santarpia, L Di Tommaso
Dis. Markers, 2018-04-16;2018(0):5018671.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Delayed and repeated intranasal delivery of bone marrow stromal cells increases regeneration and functional recovery after ischemic stroke in mice
Authors: MJ Chau, TC Deveau, X Gu, YS Kim, Y Xu, SP Yu, L Wei
BMC Neurosci, 2018-04-12;19(1):20.
Species: Rat
Sample Types: Whole Cells
Applications: ICC -
Tumor Microenvironment in Functional Adrenocortical Adenomas: Immune Cell Infiltration in Cortisol-producing Adrenocortical Adenoma
Authors: Y Kitawaki, Y Nakamura, F Kubota-Nak, Y Yamazaki, Y Miki, S Hata, K Ise, K Kikuchi, R Morimoto, F Satoh, H Sasano
Hum. Pathol., 2018-03-27;0(0):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Expression of CXC-motif-chemokine 12 and the receptor C-X-C receptor 4 in glioma and theeffect on peritumoral brain edema
Authors: W Tang, Y Chen, X Wang, Y Chen, J Zhang, Z Lin
Oncol Lett, 2017-12-08;15(2):2501-2507.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Mechanisms by which CXCR4/CXCL12 cause metastatic behavior in pancreatic cancer
Authors: J Zhang, C Liu, X Mo, H Shi, S Li
Oncol Lett, 2017-12-05;15(2):1771-1776.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
The chronically inflamed central nervous system provides niches for long-lived plasma cells
Authors: K Pollok, R Mothes, C Ulbricht, A Liebheit, JD Gerken, S Uhlmann, F Paul, R Niesner, H Radbruch, AE Hauser
Acta Neuropathol Commun, 2017-11-25;5(1):88.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
Regulation of inflammatory factors by double-stranded RNA receptors in breast cancer cells
Authors: A Venkatesh, H Nandigam, M Muccioli, M Singh, T Loftus, D Lewis, M Pate, F Benencia
Immunobiology, 2017-11-22;0(0):.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: ELISA Development (Capture) -
Cancer associated fibroblasts (CAFs) are activated in cutaneous basal cell carcinoma and in the peritumoural skin
Authors: SH Omland, EE Wettergren, S Mollerup, M Asplund, T Mourier, AJ Hansen, R Gniadecki
BMC Cancer, 2017-10-07;17(1):675.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-Fr -
Increasing tumor-infiltrating T cells through inhibition of CXCL12 with NOX-A12 synergizes with PD-1 blockade
Authors: D Zboralski, K Hoehlig, D Eulberg, A Froemming, A Vater
Cancer Immunol Res, 2017-09-28;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
SDF-1/CXCR4 expression in head and neck cancer and outcome after postoperative radiochemotherapy
Authors: C De-Colle, D Mönnich, S Welz, S Boeke, B Sipos, F Fend, PS Mauz, I Tinhofer, V Budach, JA Jawad, M Stuschke, P Balermpas, C Rödel, AL Grosu, A Abdollahi, J Debus, C Bayer, C Belka, S Pigorsch, SE Combs, F Lohaus, A Linge, M Krause, M Baumann, D Zips, A Menegakis
Clin Transl Radiat Oncol, 2017-07-14;5(0):28-36.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Hypoxia-Inducible Factor 1? Signaling Promotes Repair of the Alveolar Epithelium after Acute Lung Injury
Authors: J McClendon, NL Jansing, EF Redente, A Gandjeva, Y Ito, SP Colgan, A Ahmad, DWH Riches, HA Chapman, RJ Mason, RM Tuder, RL Zemans
Am. J. Pathol., 2017-06-12;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Dipeptidyl Peptidase-4 Inhibition Stimulates Distal Tubular Natriuresis and Increases in Circulating SDF-1?(1-67) in Patients With Type 2 Diabetes
Authors: JA Lovshin, H Rajasekera, Y Lytvyn, LE Lovblom, S Khan, R Alemu, A Locke, V Lai, H He, L Hittle, W Wang, DJ Drucker, DZI Cherney
Diabetes Care, 2017-05-26;0(0):.
Species: Human
Sample Types: Plasma
Applications: Mass Spectrometry -
A novel recombinant antibody specific to full-length stromal derived factor-1 for potential application in biomarker studies
Authors: DI Bromage, S Taferner, M Pillai, DM Yellon, SM Davidson
PLoS ONE, 2017-04-05;12(4):e0174447.
Species: Human, Rat
Sample Types: Plasma, Recombinant Protein
Applications: ELISA Development (Detection), Functional Assay -
Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells
Authors: N Guidi, M Sacma, L Ständker, K Soller, G Marka, K Eiwen, JM Weiss, F Kirchhoff, T Weil, JA Cancelas, MC Florian, H Geiger
EMBO J, 2017-03-02;0(0):.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: ELISA Development (Capture) -
Cholinergic Signals from the CNS Regulate G-CSF-Mediated HSC Mobilization from Bone Marrow via a Glucocorticoid Signaling Relay
Authors: H Pierce, D Zhang, C Magnon, D Lucas, JR Christin, M Huggins, GJ Schwartz, PS Frenette
Cell Stem Cell, 2017-02-09;0(0):.
Species: Mouse
Sample Types: Bone Marrow Fluid
Applications: ELISA Development (Capture) -
Expression and function of CXCL12/CXCR4/CXCR7 in thyroid cancer
Authors: X Zhu, Q Bai, Y Lu, Y Lu, L Zhu, X Zhou, L Wu
Int J Oncol, 2016-04-12;0(0):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
CXCR4 promotes renal tubular cell survival in male diabetic rats: implications for ligand inactivation in the human kidney.
Authors: Siddiqi, Ferhan S, Chen, Li-Hao, Advani, Suzanne, Thai, Kerri, Batchu, Sri N, Alghamdi, Tamadher, White, Kathryn, Sood, Manish M, Gibson, Ian W, Connelly, Kim A, Marsden, Philip A, Advani, Andrew
Endocrinology, 2014-12-30;156(3):1121-32.
Species: Rat
Sample Types: Whole Tissue
Applications: IHC-P -
Immunohistochemical evaluation of CXCL12-CXCR4 axis and VEGFR3 expression in primary urothelial cancer and its recurrence.
Authors: Batsi O, Giannopoulou I, Nesseris I, Valavanis C, Gakiopoulou H, Patsouris E, Arapandoni-Dadioti P, Lazaris A
Anticancer Res, 2014-07-01;34(7):3537-42.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Stromal niche communalities underscore the contribution of the matricellular protein SPARC to B-cell development and lymphoid malignancies.
Authors: Sangaletti, Sabina, Tripodo, Claudio, Portararo, Paola, Dugo, Matteo, Vitali, Caterina, Botti, Laura, Guarnotta, Carla, Cappetti, Barbara, Gulino, Alessand, Torselli, Ilaria, Casalini, Patrizia, Chiodoni, Claudia, Colombo, Mario P
Oncoimmunology, 2014-06-05;3(0):e28989.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
CXCL16 and CXCR6 are coexpressed in human lung cancer in vivo and mediate the invasion of lung cancer cell lines in vitro.
Authors: Hu, Weidong, Liu, Yue, Zhou, Wenhui, Si, Lianlian, Ren, Liang
PLoS ONE, 2014-06-04;9(6):e99056.
Species: Human
Sample Types: Whole Cells, Whole Tissue
Applications: ICC, IHC-P -
CXCR4 is dispensable for T cell egress from chronically inflamed skin via the afferent lymph.
Authors: Geherin, Skye A, Wilson, R Paul, Jennrich, Silke, Debes, Gudrun F
PLoS ONE, 2014-04-21;9(4):e95626.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Regulation of transplanted mesenchymal stem cells by the lung progenitor niche in rats with chronic obstructive pulmonary disease.
Authors: Zhang W, He L, Shi X, Wu S, Zhang B, Mei L, Xu Y, Zhang Z, Zhao J, Zhang H
Respir Res, 2014-03-25;15(0):33.
Species: Rat
Sample Types: Whole Tissue
Applications: IHC-P -
SDF-1/CXCR4 signaling preserves microvascular integrity and renal function in chronic kidney disease.
Authors: Chen L, Advani S, Thai K, Kabir M, Sood M, Gibson I, Yuen D, Connelly K, Marsden P, Kelly D, Gilbert R, Advani A
PLoS ONE, 2014-03-17;9(3):e92227.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
CXCL12 chemokine expression suppresses human pancreatic cancer growth and metastasis.
Authors: Roy, Ishan, Zimmerman, Noah P, Mackinnon, A Craig, Tsai, Susan, Evans, Douglas, Dwinell, Michael
PLoS ONE, 2014-03-04;9(3):e90400.
Species: Human
Sample Types: Cell Culture Supernates, Whole Tissue
Applications: ELISA Development (Capture), IHC -
Intracellular coexpression of CXC- and CC- chemokine receptors and their ligands in human melanoma cell lines and dynamic variations after xenotransplantation.
Authors: Pinto S, Martinez-Romero A, O'Connor J, Gil-Benso R, San-Miguel T, Terradez L, Monteagudo C, Callaghan R
BMC Cancer, 2014-02-22;14(0):118.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry, ICC -
Inhibition of CXCR7 extends survival following irradiation of brain tumours in mice and rats.
Authors: Walters, M J, Ebsworth, K, Berahovich, R D, Penfold, M E T, Liu, S-C, Al Omran, R, Kioi, M, Chernikova, S B, Tseng, D, Mulkearns-Hubert, E E, Sinyuk, M, Ransohoff, R M, Lathia, J D, Karamchandani, J, Kohrt, H E K, Zhang, P, Powers, J P, Jaen, J C, Schall, T J, Merchant, M, Recht, L, Brown, J M
Br J Cancer, 2014-01-14;110(5):1179-88.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients.
Authors: D'Alterio C, Avallone A, Tatangelo F, Delrio P, Pecori B, Cella L, Pelella A, D'Armiento F, Carlomagno C, Bianco F, Silvestro L, Pacelli R, Napolitano M, Iaffaioli R, Scala S
Int J Cancer, 2014-01-10;135(2):379-90.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
A novel, diffusely infiltrative xenograft model of human anaplastic oligodendroglioma with mutations in FUBP1, CIC, and IDH1.
Authors: Klink B, Miletic H, Stieber D, Huszthy P, Campos Valenzuela J, Balss J, Wang J, Schubert M, Sakariassen P, Sundstrom T, Torsvik A, Aarhus M, Mahesparan R, von Deimling A, Kaderali L, Niclou S, Schrock E, Bjerkvig R, Nigro J
PLoS ONE, 2013-03-19;8(3):e59773.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
CXCL12 promotes the stabilization of atherosclerotic lesions mediated by smooth muscle progenitor cells in Apoe-deficient mice.
Authors: Akhtar S, Gremse F, Kiessling F, Weber C, Schober A
Arterioscler Thromb Vasc Biol, 2013-02-07;33(4):679-86.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Involvement of the CXCR7/CXCR4/CXCL12 axis in the malignant progression of human neuroblastoma.
Authors: Liberman J, Sartelet H, Flahaut M, Muhlethaler-Mottet A, Coulon A, Nyalendo C, Vassal G, Joseph J, Gross N
PLoS ONE, 2012-08-20;7(8):e43665.
Species: Human
Sample Types: Whole Cells, Whole Tissue
Applications: ICC, IHC-P -
The SDF-1α/CXCR4 Axis is Required for Proliferation and Maturation of Human Fetal Pancreatic Endocrine Progenitor Cells.
Authors: Kayali AG, Lopez AD, Hao E, Hinton A, Hayek A, King CC
PLoS ONE, 2012-06-22;7(6):e38721.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
A dynamic inflammatory cytokine network in the human ovarian cancer microenvironment.
Authors: Kulbe H, Chakravarty P, Leinster DA, Charles KA, Kwong J, Thompson RG, Coward JI, Schioppa T, Robinson SC, Gallagher WM, Galletta L, Salako MA, Smyth JF, Hagemann T, Brennan DJ, Bowtell DD, Balkwill FR
Cancer Res., 2011-11-07;72(1):66-75.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
VEGF-DdeltaNdeltaC mediated angiogenesis in skeletal muscles of diabetic WHHL rabbits.
Authors: Roy H, Bhardwaj S, Babu M, Lahteenvuo JE, Yla-Herttuala S
Eur. J. Clin. Invest., 2010-05-01;40(5):422-32.
Species: Rabbit
Sample Types: Whole Tissue
Applications: IHC-P -
Comprehensive assessment of chemokine expression profiles by flow cytometry.
Authors: Eberlein J, Nguyen TT, Victorino F, Golden-Mason L, Rosen HR, Homann D
J. Clin. Invest., 2010-02-08;120(3):907-23.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes.
Authors: Sayyed SG, Hagele H, Kulkarni OP, Endlich K, Segerer S, Eulberg D, Klussmann S, Anders HJ
Diabetologia, 2009-08-26;52(11):2445-54.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
Targeted disruption of the CXCL12/CXCR4 axis inhibits osteolysis in a murine model of myeloma-associated bone loss.
Authors: Diamond P, Labrinidis A, Martin SK, Farrugia AN, Gronthos S, To LB, Fujii N, O'Loughlin PD, Evdokiou A, Zannettino AC
J. Bone Miner. Res., 2009-07-01;24(7):1150-61.
Species: Human
Sample Types: Whole Cells, Whole Tissue
Applications: Flow Cytometry, IHC-P -
CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy.
Authors: Zhu Y, Vergote D, Pardo C, Noorbakhsh F, McArthur JC, Hollenberg MD, Overall CM, Power C
FASEB J., 2009-04-20;23(9):2928-41.
Species: Feline
Sample Types: Tissue Homogenates
Applications: Western Blot -
Citrullination of CXCL12 differentially reduces CXCR4 and CXCR7 binding with loss of inflammatory and anti-HIV-1 activity via CXCR4.
Authors: Struyf S, Noppen S, Loos T, Mortier A, Gouwy M, Verbeke H, Huskens D, Luangsay S, Parmentier M, Geboes K, Schols D, Van Damme J, Proost P
J. Immunol., 2009-01-01;182(1):666-74.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Clinical and biological significance of CXCL12 and CXCR4 expression in adult testes and germ cell tumours of adults and adolescents.
Authors: Gilbert DC, Chandler I, McIntyre A, Goddard NC, Gabe R, Huddart RA, Shipley J
J. Pathol., 2009-01-01;217(1):94-102.
Species: Human
Sample Types: Whole Cells, Whole Tissue
Applications: ICC, IHC-P -
Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment.
Authors: Albanesi C, Scarponi C, Pallotta S, Daniele R, Bosisio D, Madonna S, Fortugno P, Gonzalvo-Feo S, Franssen JD, Parmentier M, De Pita O, Girolomoni G, Sozzani S
J. Exp. Med., 2008-12-29;206(1):249-58.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo.
Authors: Biancotto A, Iglehart SJ, Lisco A, Vanpouille C, Grivel JC, Lurain NS, Reichelderfer PS, Margolis LB
AIDS Res. Hum. Retroviruses, 2008-03-01;24(3):453-62.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Luminex Development -
pVHL co-ordinately regulates CXCR4/CXCL12 and MMP2/MMP9 expression in human clear-cell renal cell carcinoma.
Authors: Struckmann K, Mertz K, Steu S, Storz M, Staller P, Krek W, Schraml P, Moch H
J. Pathol., 2008-03-01;214(4):464-71.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Hypoxia-induced mediators of stem/progenitor cell trafficking are increased in children with hemangioma.
Authors: Kleinman ME, Greives MR, Churgin SS, Blechman KM, Chang EI, Ceradini DJ, Tepper OM, Gurtner GC
Arterioscler. Thromb. Vasc. Biol., 2007-09-13;27(12):2664-70.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Pulmonary stromal-derived factor-1 expression and effect on neutrophil recruitment during acute lung injury.
Authors: Petty JM, Sueblinvong V, Lenox CC, Jones CC, Cosgrove GP, Cool CD, Rai PR, Brown KK, Weiss DJ, Poynter ME, Suratt BT
J. Immunol., 2007-06-15;178(12):8148-57.
Species: Human, Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
Dynamic stromal-epithelial interactions during progression of MCF10DCIS.com xenografts.
Authors: Tait LR, Pauley RJ, Santner SJ, Heppner GH, Heng HH, Rak JW, Miller FR
Int. J. Cancer, 2007-05-15;120(10):2127-34.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1.
Authors: Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM
Blood, 2007-02-08;109(10):4272-9.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Luminex Development -
HIV-1-infected and/or immune activated macrophages regulate astrocyte SDF-1 production through IL-1beta.
Authors: Peng H, Erdmann N, Whitney N, Dou H, Gorantla S, Gendelman HE, Ghorpade A, Zheng J
Glia, 2006-11-01;54(6):619-29.
Species: Human, Mouse
Sample Types: Cell Culture Supernates, Whole Tissue
Applications: ELISA Development, IHC-P -
Cutting edge: nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis.
Authors: Marchal-Somme J, Uzunhan Y, Marchand-Adam S, Valeyre D, Soumelis V, Crestani B, Soler P
J. Immunol., 2006-05-15;176(10):5735-9.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-Fr -
Importance of recruitment of bone marrow-derived CXCR4+ cells in post-infarct cardiac repair mediated by G-CSF.
Authors: Misao Y, Takemura G, Arai M, Ohno T, Onogi H, Takahashi T, Minatoguchi S, Fujiwara T, Fujiwara H
Cardiovasc. Res., 2006-05-09;71(3):455-65.
Species: Rabbit
Sample Types: Tissue Homogenates, Whole Tissue
Applications: IHC-P, Western Blot -
Hyaluronan-based polymer scaffold modulates the expression of inflammatory and degradative factors in mesenchymal stem cells: Involvement of Cd44 and Cd54.
Authors: Lisignoli G, Cristino S, Piacentini A, Cavallo C, Caplan AI, Facchini A
J. Cell. Physiol., 2006-05-01;207(2):364-73.
Species: Human
Sample Types: Cell Culture Supernates
Applications: ELISA Development -
Expression and regulation of the orphan receptor RDC1 and its putative ligand in human dendritic and B cells.
Authors: Infantino S, Moepps B, Thelen M
J. Immunol., 2006-02-15;176(4):2197-207.
Species: Human
Sample Types: Cell Culture Supernates
Applications: ELISA Development -
Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer.
Authors: Yasumoto K, Koizumi K, Kawashima A, Saitoh Y, Arita Y, Shinohara K, Minami T, Nakayama T, Sakurai H, Takahashi Y, Yoshie O, Saiki I
Cancer Res., 2006-02-15;66(4):2181-7.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Regulation of SDF-1 (CXCL12) production by osteoblasts; a possible mechanism for stem cell homing.
Authors: Jung Y, Wang J, Schneider A, Sun YX, Koh-Paige AJ, Osman NI, McCauley LK, Taichman RS
Bone, 2005-12-05;38(4):497-508.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
Skin homing of Sezary cells involves SDF-1-CXCR4 signaling and down-regulation of CD26/dipeptidylpeptidase IV.
Authors: Narducci MG, Scala E, Bresin A, Caprini E, Picchio MC, Remotti D, Ragone G, Nasorri F, Frontani M, Arcelli D, Volinia S, Lombardo GA, Baliva G, Napolitano M, Russo G
Blood, 2005-10-04;107(3):1108-15.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Age-associated aortic stenosis in apolipoprotein E-deficient mice.
Authors: Tanaka K, Sata M, Fukuda D, Suematsu Y, Motomura N, Takamoto S, Hirata Y, Nagai R
J. Am. Coll. Cardiol., 2005-07-05;46(1):134-41.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Recruitment of osteoclast precursors by stromal cell derived factor-1 (SDF-1) in giant cell tumor of bone.
Authors: Liao TS, Yurgelun MB, Chang SS, Zhang HZ, Murakami K, Blaine TA, Parisien MV, Kim W, Winchester RJ, Lee FY
J. Orthop. Res., 2005-01-01;23(1):203-9.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands.
Authors: Kohrgruber N, Groger M, Meraner P, Kriehuber E, Petzelbauer P, Brandt S, Stingl G, Rot A, Maurer D
J. Immunol., 2004-12-01;173(11):6592-602.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Thymic T cell development and progenitor localization depend on CCR7.
Authors: Misslitz A, Pabst O, Hintzen G, Ohl L, Kremmer E, Petrie HT, Forster R
J. Exp. Med., 2004-08-09;200(4):481-91.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Involvement of the CXCL12/CXCR4 pathway in the advanced liver disease that is associated with hepatitis C virus or hepatitis B virus.
Authors: Wald O, Pappo O, Safadi R, Dagan-Berger M, Beider K, Wald H, Franitza S, Weiss I, Avniel S, Boaz P, Hanna J, Zamir G, Eid A, Mandelboim O, Spengler U, Galun E, Peled A
Eur. J. Immunol., 2004-04-01;34(4):1164-74.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Characterization of hematopoietic progenitor mobilization in protease-deficient mice.
Authors: Levesque JP, Liu F, Simmons PJ, Betsuyaku T, Senior RM, Pham C, Link DC
Blood, 2004-03-09;104(1):65-72.
Species: Mouse
Sample Types: Bone Marrow Fluid
Applications: ELISA Development -
Serum inactivation contributes to the failure of stromal-derived factor-1 to block HIV-I infection in vivo.
Authors: Villalba S, Salvucci O, Aoki Y, De La Luz Sierra M, Gupta G, Davis D, Wyvill K, Little R, Yarchoan R, Tosato G
J. Leukoc. Biol., 2003-07-22;74(5):880-8.
Species: Human
Sample Types: Serum
Applications: ELISA Development
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Epitope retrieval: Leica BOND ER2 (high-pH) 100C 40min
Primary Ab: 5ug/mL in BSA/TBS for 30min
Detection system: Leica BOND-RX autostainer with Leica BOND refine detection kit
1:100
Citrate buffer antigen retrieval
FFPE tissues