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Human/Mouse E-Cadherin Antibody

Catalog #: AF748
69 Citations 10 Reviews Datasheet / COA / SDS
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AF748
AF748-SP
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Detection of Human and Mouse E‑Cadherin by Western Blot.
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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human/Mouse E-Cadherin Antibody Summary

Species Reactivity
Human, Mouse
Specificity
Detects mouse E-Cadherin in direct ELISAs and Western blots.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse E-Cadherin
Asp157-Val709
Accession # P09803
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
0.5 µg/mL
See below
Simple Western
5 µg/mL
See below
Flow Cytometry
0.25 µg/106 cells
D3 mouse embryonic stem cell line
Immunohistochemistry
5-15 µg/mL
See below
CyTOF-ready
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
 
Immunocytochemistry
5-15 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Human and Mouse E-Cadherin antibody by Western Blot. View Larger

Detection of Human and Mouse E‑Cadherin by Western Blot. Western blot shows lysates of A431 human epithelial carcinoma cell line, A549 human lung carcinoma cell line, HepG2 human hepatocellular carcinoma cell line, P19 mouse embryonal carcinoma cell line, and 4T1 mouse breast cancer cell line. PVDF membrane was probed with 0.5 µg/mL of Goat Anti-Human/Mouse E-Cadherin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF748) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF017). A specific band was detected for E-Cadherin at approximately 110 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Immunocytochemistry E-Cadherin antibody in D3 Mouse Embryonic Stem Cell Line by Immunocytochemistry (ICC). View Larger

E‑Cadherin in D3 Mouse Embryonic Stem Cell Line. E-Cadherin was detected in immersion fixed D3 mouse embryonic stem cell line using Goat Anti-Human/Mouse E-Cadherin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF748) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # NL001) and counterstained with DAPI (blue). Specific staining was localized to cell surfaces. View our protocol for Fluorescent ICC Staining of Stem Cells on Coverslips.

Immunohistochemistry E-Cadherin antibody in Mouse Skin by Immunohistochemistry (IHC-Fr). View Larger

E‑Cadherin in Mouse Skin. E-Cadherin was detected in perfusion fixed frozen sections of mouse skin using Goat Anti-Human/Mouse E-Cadherin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF748) at 1.7 µg/mL overnight at 4 °C. Tissue was stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # NL001) and counterstained with DAPI (blue). Specific staining was localized to plasma membranes in keratinocytes. View our protocol for Fluorescent IHC Staining of Frozen Tissue Sections.

Immunocytochemistry E-Cadherin antibody in Mouse Intestinal Organoids by Immunocytochemistry (ICC). View Larger

E‑Cadherin in Mouse Intestinal Organoids. E-Cadherin was detected in immersion fixed mouse intestinal organoids using Goat Anti-Human/Mouse E-Cadherin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF748) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (green; Catalog # NL001) and counterstained with DAPI (blue). Magnification shown at 100X (upper panel) and 40X (lower panel). Specific staining was localized to cell surfaces. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Immunocytochemistry E-Cadherin antibody in Mouse Intestinal Organoids by Immunocytochemistry (ICC). View Larger

E‑Cadherin in Mouse Intestinal Organoids. E-Cadherin was detected in immersion fixed mouse intestinal organoids using Goat Anti-Human/Mouse E-Cadherin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF748) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 493-conjugated Anti-Goat IgG Secondary Antibody (green; Catalog # NL003) and counterstained with DAPI (blue). Specific staining was localized to cell surfaces. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Immunohistochemistry E-Cadherin antibody in Mouse Spinal Cord by Immunohistochemistry (IHC-Fr). View Larger

E‑Cadherin in Mouse Spinal Cord. E-Cadherin was detected in perfusion fixed frozen sections of mouse spinal cord using Goat Anti-Human/Mouse E-Cadherin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF748) at 1.7 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Specific staining was localized to dorsal horn. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.

Simple Western Detection of Human and Mouse E-Cadherin antibody by Simple Western<sup>TM</sup>. View Larger

Detection of Human and Mouse E‑Cadherin by Simple WesternTM. Simple Western lane view shows lysates of 4T1 mouse breast cancer cell line, P19 mouse embryonal carcinoma cell line, A431 human epithelial carcinoma cell line, and MCF-7 human breast cancer cell line, loaded at 0.2 mg/mL. A specific band was detected for E-Cadherin at approximately 128 kDa (as indicated) using 5 µg/mL of Goat Anti-Human/Mouse E-Cadherin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF748) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: E-Cadherin

Epithelial (E)‑Cadherin (ECAD), also known as cell-CAM120/80 in the human, uvomorulin in the mouse, Arc-1 in the dog, and L-CAM in the chicken, is a member of the cadherin family of cell adhesion molecules. Cadherins are calcium-dependent transmembrane proteins, which bind to one another in a homophilic manner. On their cytoplasmic side, they associate with the three catenins, alpha, beta, and gamma (plakoglobin). This association links the cadherin protein to the cytoskeleton. Without association with the catenins, the cadherins are non-adhesive. Cadherins play a role in development, specifically in tissue formation. They may also help to maintain tissue architecture in the adult. E-Cadherin may also play a role in tumor development, as loss of E-Cadherin has been associated with tumor invasiveness. E-Cadherin is a classical cadherin molecule. Classical cadherins consist of a large extracellular domain which contains DXD and DXNDN repeats responsible for mediating calcium‑dependent adhesion, a single-pass transmembrane domain, and a short carboxy-terminal cytoplasmic domain responsible for interacting with the catenins. E‑Cadherin contains five extracellular calcium-binding domains of approximately 110 amino acids each.

References
  1. Bussemakers, M.J.G. et al. (1993) Mol. Biol. Reports 17:123.
  2. Overduin, M. et al. (1995) Science 267:386.
  3. Takeichi, M. (1991) 251:1451.
Entrez Gene IDs
999 (Human); 12550 (Mouse); 83502 (Rat)
Alternate Names
Arc-1; CAD1; cadherin 1, E-cadherin (epithelial); cadherin 1, type 1, E-cadherin (epithelial); Cadherin-1; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324 antigen; CD324; CDH1; CDHE; cell-CAM 120/80; Cell-CAM120/80; ECAD; ECadherin; E-Cadherin; Epithelial cadherin; LCAM; L-CAM; UVOE-Cadherin; Uvomorulin

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Citations for Human/Mouse E-Cadherin Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

69 Citations: Showing 1 - 10
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  1. Venous-plexus-associated lymphoid hubs support meningeal humoral immunity
    Authors: Fitzpatrick, Z;Ghabdan Zanluqui, N;Rosenblum, JS;Tuong, ZK;Lee, CYC;Chandrashekhar, V;Negro-Demontel, ML;Stewart, AP;Posner, DA;Buckley, M;Allinson, KSJ;Mastorakos, P;Chittiboina, P;Maric, D;Donahue, D;Helmy, A;Tajsic, T;Ferdinand, JR;Portet, A;Peñalver, A;Gillman, E;Zhuang, Z;Clatworthy, MR;McGavern, DB;
    Nature
    Species: Murine polyomavirus strain A3
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  2. Delivery of a BET protein degrader via a CEACAM6-targeted antibody-drug conjugate inhibits tumour growth in pancreatic cancer models
    Authors: Nakazawa, Y;Miyano, M;Tsukamoto, S;Kogai, H;Yamamoto, A;Iso, K;Inoue, S;Yamane, Y;Yabe, Y;Umihara, H;Taguchi, J;Akagi, T;Yamaguchi, A;Koga, M;Toshimitsu, K;Hirayama, T;Mukai, Y;Machinaga, A;
    Nature communications
    Species: Murine polyomavirus strain A3
    Sample Types: Organoid, Whole Tissue
    Applications: Immunohistochemistry
  3. Measurement of adhesion and traction of cells at high yield (MATCHY) reveals an energetic ratchet driving nephron condensation
    Authors: Liu, J;Prahl, LS;Huang, A;Hughes, AJ;
    bioRxiv : the preprint server for biology
    Species: Murine polyomavirus strain A3
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  4. Opposing roles for TGF?- and BMP-signaling during nascent alveolar differentiation in the developing human lung
    Authors: Frum, T;Hsu, PP;Hein, RFC;Conchola, AS;Zhang, CJ;Utter, OR;Anand, A;Zhang, Y;Clark, SG;Glass, I;Sexton, JZ;Spence, JR;
    bioRxiv : the preprint server for biology
    Species:  Human
    Sample Types: Whole Tissue
    Applications: IHC
  5. IGFBP2 expressing midlobular hepatocytes preferentially contribute to liver homeostasis and regeneration
    Authors: Lin, YH;Wei, Y;Zeng, Q;Wang, Y;Pagani, CA;Li, L;Zhu, M;Wang, Z;Hsieh, MH;Corbitt, N;Zhang, Y;Sharma, T;Wang, T;Zhu, H;
    Cell stem cell
    Species: Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  6. Non-optimal bacteria species induce neutrophil-driven inflammation and barrier disruption in the female genital tract
    Authors: M Costa Fuji, A Yazdanpana, S Horne, A Lamont, P Lopez, C Farr Zuend, K Birse, M Taverner, R Greenslade, M Abou, L Noel-Romas, B Abrenica, O Ajibola, N Ikeogu, RC Su, LR McKinnon, H Pymar, V Poliquin, AR Berard, A Burgener, TT Murooka
    Mucosal Immunology, 2023-04-29;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  7. Uropathogenic Escherichia coli infection-induced epithelial trained immunity impacts urinary tract disease outcome
    Authors: SK Russell, JK Harrison, BS Olson, HJ Lee, VP O'Brien, X Xing, J Livny, L Yu, EDO Roberson, R Bomjan, C Fan, M Sha, S Estfanous, AO Amer, M Colonna, TS Stappenbec, T Wang, TJ Hannan, SJ Hultgren
    Nature Microbiology, 2023-04-10;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  8. Taste papilla cell differentiation requires tongue mesenchyme via ALK3-BMP signaling to regulate the production of secretory proteins
    Authors: M Ishan, Z Wang, P Zhao, Y Yao, S Stice, L Wells, Y Mishina, HX Liu
    bioRxiv : the preprint server for biology, 2023-04-04;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  9. Non-canonical functions of SNAIL drive context-specific cancer progression
    Authors: MC Paul, C Schneeweis, C Falcomatà, C Shan, D Rossmeisl, S Koutsouli, C Klement, M Zukowska, SA Widholz, M Jesinghaus, KK Heuermann, T Engleitner, B Seidler, K Sleiman, K Steiger, M Tschurtsch, B Walter, SA Weidemann, R Pietsch, A Schnieke, RM Schmid, MS Robles, G Andrieux, M Boerries, R Rad, G Schneider, D Saur
    Nature Communications, 2023-03-07;14(1):1201.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  10. Cell-autonomous requirement for ACE2 across organs in lethal mouse SARS-CoV-2 infection
    Authors: AT Tang, DW Buchholz, KM Szigety, B Imbiakha, S Gao, M Frankfurte, M Wang, J Yang, P Hewins, P Mericko-Is, NA Leu, S Sterling, IA Monreal, J Sahler, A August, X Zhu, KA Jurado, M Xu, EE Morrisey, SE Millar, HC Aguilar, ML Kahn
    PloS Biology, 2023-02-06;21(2):e3001989.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  11. Bone metastasis initiation is coupled with bone remodeling through osteogenic differentiation of NG2+ cells
    Authors: W Zhang, Z Xu, X Hao, T He, J Li, Y Shen, K Liu, Y Gao, J Liu, D Edwards, AM Muscarella, L Wu, L Yu, L Xu, X Chen, YH Wu, IL Bado, Y Ding, S Aguirre, H Wang, Z Gugala, RL Satcher, ST Wong, XH Zhang
    Cancer Discovery, 2023-02-06;0(0):.
    Species: Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  12. Non-canonical functions of SNAIL drive context-specific cancer progression
    Authors: MC Paul, C Schneeweis, C Falcomatà, C Shan, D Rossmeisl, S Koutsouli, C Klement, M Zukowska, SA Widholz, M Jesinghaus, KK Heuermann, T Engleitner, B Seidler, K Sleiman, K Steiger, M Tschurtsch, B Walter, SA Weidemann, R Pietsch, A Schnieke, RM Schmid, MS Robles, G Andrieux, M Boerries, R Rad, G Schneider, D Saur
    Nature Communications, 2023;14(1):1201.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  13. Multiscale profiling of protease activity in cancer
    Authors: AP Amini, JD Kirkpatric, CS Wang, AM Jaeger, S Su, S Naranjo, Q Zhong, CM Cabana, T Jacks, SN Bhatia
    Nature Communications, 2022-10-03;13(1):5745.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  14. The NALCN channel regulates metastasis and nonmalignant cell dissemination
    Authors: EP Rahrmann, D Shorthouse, A Jassim, LP Hu, M Ortiz, B Mahler-Ara, P Vogel, M Paez-Ribes, A Fatemi, GJ Hannon, R Iyer, JA Blundon, FC Lourenço, J Kay, RM Nazarian, BA Hall, SS Zakharenko, DJ Winton, L Zhu, RJ Gilbertson
    Nature Genetics, 2022-09-29;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  15. Adherens junctions stimulate and spatially guide integrin activation and extracellular matrix deposition
    Authors: R Hadjisavva, O Anastasiou, PS Ioannou, M Zheltkova, PA Skourides
    Oncogene, 2022-07-19;40(3):111091.
    Species: Xenopus
    Sample Types: Embryos
    Applications: IHC
  16. Lymphatics act as a signaling hub to regulate intestinal stem cell activity
    Authors: RE Niec, T Chu, M Schernthan, S Gur-Cohen, L Hidalgo, HA Pasolli, KA Luckett, Z Wang, SR Bhalla, F Cambuli, RP Kataru, K Ganesh, BJ Mehrara, D Pe'er, E Fuchs
    Cell Stem Cell, 2022-06-20;29(7):1067-1082.e18.
    Species: Human, Mouse
    Sample Types: Cell Lysates, Tissue Homogenates
    Applications: Western Blot
  17. Ex Vivo Perfusion Using a Mathematical Modeled, Controlled Gas Exchange Self-Contained Bioreactor Can Maintain a Mouse Kidney for Seven Days
    Authors: N Won, J Castillo-P, X Tan, J Ford, D Heath, LI Mazilescu, M Selzner, IM Rogers
    Cells, 2022-06-02;11(11):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  18. Amniogenesis occurs in two independent waves in primates
    Authors: M Rostovskay, S Andrews, W Reik, PJ Rugg-Gunn
    Cell Stem Cell, 2022-04-18;29(5):744-759.e6.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  19. Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing
    Authors: N Frey, L Tortola, D Egli, S Janjuha, T Rothgangl, KF Marquart, F Ampenberge, M Kopf, G Schwank
    Nature Communications, 2022-04-04;13(1):1804.
    Species: Human
    Sample Types: Organoids
    Applications: IHC
  20. Suspension culture promotes serosal mesothelial development in human intestinal organoids
    Authors: MM Capeling, S Huang, CJ Childs, JH Wu, YH Tsai, A Wu, N Garg, EM Holloway, N Sundaram, C Bouffi, M Helmrath, JR Spence
    Cell Reports, 2022-02-15;38(7):110379.
    Species: Human
    Sample Types: Oraganoids
    Applications: IHC
  21. E-Cadherin-Deficient Epithelial Cells Are Sensitive to HDAC Inhibitors
    Authors: L Decourtye-, N Bougen-Zhu, T Godwin, T Brew, E Schulpen, MA Black, P Guilford
    Cancers, 2021-12-30;14(1):.
    Species: Mouse
    Sample Types: Organoids
    Applications: IHC, Western Blot
  22. Loss of E-Cadherin Leads to Druggable Vulnerabilities in Sphingolipid Metabolism and Vesicle Trafficking
    Authors: T Brew, N Bougen-Zhu, W Mitchell, L Decourtye, E Schulpen, Y Nouri, T Godwin, P Guilford
    Cancers, 2021-12-26;14(1):.
    Species: Transgenic Mouse
    Sample Types: Organoids
    Applications: IHC
  23. Differentiation of mouse fetal lung alveolar progenitors in serum-free organotypic cultures
    Authors: K Gkatzis, P Panza, S Peruzzo, DY Stainier
    Elife, 2021-09-29;10(0):.
    Species: Mouse
    Sample Types: Organoids
    Applications: IHC
  24. Reciprocal interplay between asporin and decorin: Implications in gastric cancer prognosis
    Authors: D Basak, Z Jamal, A Ghosh, PK Mondal, P Dey Talukd, S Ghosh, B Ghosh Roy, R Ghosh, A Halder, A Chowdhury, GK Dhali, BK Chattopadh, ML Saha, A Basu, S Roy, C Mukherjee, NK Biswas, U Chatterji, S Datta
    PLoS ONE, 2021-08-11;16(8):e0255915.
    Species: Human
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  25. Primary cilia-dependent lipid raft/caveolin dynamics regulate adipogenesis
    Authors: D Yamakawa, D Katoh, K Kasahara, T Shiromizu, M Matsuyama, C Matsuda, Y Maeno, M Watanabe, Y Nishimura, M Inagaki
    Cell Reports, 2021-03-09;34(10):108817.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC
  26. Maternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis
    Authors: P Lu, Y Yamaguchi, WB Fulton, S Wang, Q Zhou, H Jia, ML Kovler, AG Salazar, M Sampah, T Prindle, P Wipf, CP Sodhi, DJ Hackam
    Nature Communications, 2021-02-15;12(1):1042.
    Species: Human, Mouse, Porcine
    Sample Types: Whole Tissue
    Applications: IHC
  27. The Expression Levels and Cellular Localization of Pigment Epithelium Derived Factor (PEDF) in Mouse Testis: Its Possible Involvement in the Differentiation of Spermatogonial Cells
    Authors: N Bagdadi, A Sawaied, A AbuMadighe, E Lunenfeld, M Huleihel
    International Journal of Molecular Sciences, 2021-01-24;22(3):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  28. Mapping Development of the Human Intestinal Niche at Single-Cell Resolution
    Authors: EM Holloway, M Czerwinski, YH Tsai, JH Wu, A Wu, CJ Childs, KD Walton, CW Sweet, Q Yu, I Glass, B Treutlein, JG Camp, JR Spence
    Cell Stem Cell, 2020-12-04;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  29. Three-Dimensional Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2
    Authors: J Youk, T Kim, KV Evans, YI Jeong, Y Hur, SP Hong, JH Kim, K Yi, SY Kim, KJ Na, T Bleazard, HM Kim, M Fellows, KT Mahbubani, K Saeb-Parsy, SY Kim, YT Kim, GY Koh, BS Choi, YS Ju, JH Lee
    Cell Stem Cell, 2020-10-21;27(6):905-919.e10.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  30. Mycotoxin Deoxynivalenol Has Different Impacts on Intestinal Barrier and Stem Cells by Its Route of Exposure
    Authors: H Hanyu, Y Yokoi, K Nakamura, T Ayabe, K Tanaka, K Uno, K Miyajima, Y Saito, K Iwatsuki, M Shimizu, M Tadaishi, K Kobayashi-
    Toxins (Basel), 2020-09-24;12(10):.
    Species: Mouse
    Sample Types: Organoid
    Applications: IHC
  31. Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi
    Authors: SP Hong, MJ Yang, H Cho, I Park, H Bae, K Choe, SH Suh, RH Adams, K Alitalo, D Lim, GY Koh
    Nat Commun, 2020-08-14;11(1):4102.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  32. Dysregulation of intestinal epithelial CFTR-dependent Cl- ion transport and paracellular barrier function drives gastrointestinal symptoms of food-induced anaphylaxis in mice
    Authors: A Yamani, D Wu, R Ahrens, L Waggoner, TK Noah, V Garcia-Her, C Ptaschinsk, CA Parkos, NW Lukacs, A Nusrat, SP Hogan
    Mucosal Immunol, 2020-06-23;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  33. CD137 Signaling Regulates Acute Colitis via RALDH2-Expressing CD11b-CD103+ DCs
    Authors: J Jin, IH Jung, SH Moon, S Jeon, SJ Jeong, SK Sonn, S Seo, MN Lee, EJ Song, HY Kweon, S Kim, TK Kim, J Kim, HR Cho, JH Choi, B Kwon, GT Oh
    Cell Rep, 2020-03-24;30(12):4124-4136.e5.
    Species: Mouse
    Sample Types: Colon Tissue
    Applications: IHC
  34. Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-&beta Resistance
    Authors: T Ringel, N Frey, F Ringnalda, S Janjuha, S Cherkaoui, S Butz, S Srivatsa, M Pirkl, G Russo, L Villiger, G Rogler, H Clevers, N Beerenwink, N Zamboni, T Baubec, G Schwank
    Cell Stem Cell, 2020-03-05;26(3):431-440.e8.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  35. A novel role for necroptosis in the pathogenesis of necrotizing enterocolitis
    Authors: AD Werts, WB Fulton, MR Ladd, A Saad-Eldin, YX Chen, ML Kovler, H Jia, EC Banfield, R Buck, K Goerhing, T Prindle, S Wang, Q Zhou, P Lu, Y Yamaguchi, CP Sodhi, DJ Hackam
    Cell Mol Gastroenterol Hepatol, 2019-11-19;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  36. Lack of whey acidic protein four disulphide core (WFDC) 2 protease inhibitor causes neonatal death from respiratory failure in mice
    Authors: K Nakajima, M Ono, U Radovi?, S Dizdarevi?, SI Tomizawa, K Kuroha, G Naganatsu, I Hoshi, R Matsunaga, T Shirakawa, T Kurosawa, Y Miyazaki, M Seki, Y Suzuki, H Koseki, M Nakamura, T Suda, K Ohbo
    Dis Model Mech, 2019-11-12;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: IHC, Western Blot
  37. Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo
    Authors: M Reed, AC Luissint, V Azcutia, S Fan, MN O'Leary, M Quiros, J Brazil, A Nusrat, CA Parkos
    Nat Commun, 2019-11-01;10(1):5004.
    Species: Mouse
    Sample Types: Cells
    Applications: IF
  38. Pparg promotes differentiation and regulates mitochondrial gene expression in bladder epithelial cells
    Authors: C Liu, T Tate, E Batourina, ST Truschel, S Potter, M Adam, T Xiang, M Picard, M Reiley, K Schneider, M Tamargo, C Lu, X Chen, J He, H Kim, CL Mendelsohn
    Nat Commun, 2019-10-09;10(1):4589.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  39. Pharmacological reversal of renal cysts from secretion to absorption suggests a potential therapeutic strategy for managing polycystic kidney disease
    Authors: MK Yanda, B Cha, C Cebotaru, L Cebotaru
    J. Biol. Chem., 2019-09-30;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Confocal Microscopy
  40. Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer
    Authors: DM Gay, RA Ridgway, M Müeller, MC Hodder, A Hedley, W Clark, JD Leach, R Jackstadt, C Nixon, DJ Huels, AD Campbell, TG Bird, OJ Sansom
    Nat Commun, 2019-02-13;10(1):723.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Proximity Ligation Assay (PLA)
  41. Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA
    Authors: MA Scavuzzo, J Chmielowie, D Yang, K Wamble, LS Chaboub, L Duraine, B Tepe, SM Glasgow, BR Arenkiel, C Brou, B Deneen, M Borowiak
    Cell Rep, 2018-12-26;25(13):3811-3827.e7.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  42. Host restriction of Escherichia coli recurrent urinary tract infection occurs in a bacterial strain-specific manner
    Authors: VP O'Brien, DA Dorsey, TJ Hannan, SJ Hultgren
    PLoS Pathog., 2018-12-13;14(12):e1007457.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  43. Analysis of leukocyte transepithelial migration using an in vivo murine colonic loop model
    Authors: S Flemming, AC Luissint, A Nusrat, CA Parkos
    JCI Insight, 2018-10-18;3(20):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  44. Polyploid Superficial Cells that Maintain the Urothelial Barrier Are Produced via Incomplete Cytokinesis and Endoreplication
    Authors: J Wang, E Batourina, K Schneider, S Souza, T Swayne, C Liu, CD George, T Tate, H Dan, G Wiessner, Y Zhuravlev, JC Canman, IU Mysorekar, CL Mendelsohn
    Cell Rep, 2018-10-09;25(2):464-477.e4.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  45. Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination
    Authors: O Nekrasova, RM Harmon, JA Broussard, JL Koetsier, LM Godsel, GN Fitz, ML Gardel, KJ Green
    Nat Commun, 2018-03-13;9(1):1053.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  46. NANOS2 acts as an intrinsic regulator of gonocytes-to-spermatogonia transition in the murine testes
    Authors: HP Pui, Y Saga
    Mech. Dev., 2018-01-12;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  47. Combined mutation of Apc, Kras and Tgfbr2 effectively drives metastasis of intestinal cancer
    Authors: E Sakai, M Nakayama, H Oshima, Y Kouyama, A Niida, S Fujii, A Ochiai, KI Nakayama, K Mimori, Y Suzuki, CP Hong, CY Ock, SJ Kim, M Oshima
    Cancer Res., 2017-12-27;0(0):.
  48. Multicolor quantitative confocal imaging cytometry
    Authors: DL Coutu, KD Kokkaliari, L Kunz, T Schroeder
    Nat. Methods, 2017-11-13;15(1):39-46.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  49. Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic ? Cell Hyperplasia in Mice
    Authors: J Kim, H Okamoto, Z Huang, G Anguiano, S Chen, Q Liu, K Cavino, Y Xin, E Na, R Hamid, J Lee, B Zambrowicz, R Unger, AJ Murphy, Y Xu, GD Yancopoulo, WH Li, J Gromada
    Cell Metab., 2017-06-06;25(6):1348-1361.e8.
  50. Distinct Requirements for FGFR1 and FGFR2 in Primitive Endoderm Development and Exit from Pluripotency
    Authors: A Molotkov, P Mazot, JR Brewer, RM Cinalli, P Soriano
    Dev. Cell, 2017-05-25;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  51. Novel role for IL-22 in protection during chronic Mycobacterium tuberculosis HN878 infection
    Authors: P Treerat, O Prince, A Cruz-Lagun, M Muñoz-Torr, MA Salazar-Le, M Selman, B Fallert-Ju, TA Reinhardt, JF Alcorn, D Kaushal, J Zuñiga, J Rangel-Mor, JK Kolls, SA Khader
    Mucosal Immunol, 2017-03-01;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  52. Maintenance of Taste Organs Is Strictly Dependent on Epithelial Hedgehog/GLI Signaling
    PLoS Genet, 2016-11-28;12(11):e1006442.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  53. A mucosal imprint left by prior Escherichia coli bladder infection sensitizes to recurrent disease
    Nat Microbiol, 2016-10-31;2(0):16196.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  54. Dazl is a target RNA suppressed by mammalian NANOS2 in sexually differentiating male germ cells
    Authors: Y Kato, T Katsuki, H Kokubo, A Masuda, Y Saga
    Nat Commun, 2016-04-13;7(0):11272.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  55. E-cadherin can limit the transforming properties of activating beta-catenin mutations.
    Authors: Huels D, Ridgway R, Radulescu S, Leushacke M, Campbell A, Biswas S, Leedham S, Serra S, Chetty R, Moreaux G, Parry L, Matthews J, Song F, Hedley A, Kalna G, Ceteci F, Reed K, Meniel V, Maguire A, Doyle B, Soderberg O, Barker N, Watson A, Larue L, Clarke A, Sansom O
    EMBO J, 2015-08-03;34(18):2321-33.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  56. Mitogen-activated protein kinase (MAPK) pathway regulates branching by remodeling epithelial cell adhesion.
    Authors: Ihermann-Hella A, Lume M, Miinalainen I, Pirttiniemi A, Gui Y, Peranen J, Charron J, Saarma M, Costantini F, Kuure S
    PLoS Genet, 2014-03-06;10(3):e1004193.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC
  57. AKT3 regulates ErbB2, ErbB3 and estrogen receptor alpha expression and contributes to endocrine therapy resistance of ErbB2(+) breast tumor cells from Balb-neuT mice.
    Authors: Grabinski N, Mollmann K, Milde-Langosch K, Muller V, Schumacher U, Brandt B, Pantel K, Jucker M
    Cell Signal, 2014-01-24;26(5):1021-9.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  58. Annexin A2 mediates secretion of collagen VI, pulmonary elasticity and apoptosis of bronchial epithelial cells.
    Authors: Dassah M, Almeida D, Hahn R, Bonaldo P, Worgall S, Hajjar K
    J Cell Sci, 2013-12-19;127(0):828-44.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Neutralization
  59. Bifidobacterium longum alleviates dextran sulfate sodium-induced colitis by suppressing IL-17A response: involvement of intestinal epithelial costimulatory molecules.
    Authors: Miyauchi, Eiji, Ogita, Tasuku, Miyamoto, Junki, Kawamoto, Seiji, Morita, Hidetosh, Ohno, Hiroshi, Suzuki, Takuya, Tanabe, Soichi
    PLoS ONE, 2013-11-08;8(11):e79735.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  60. MMP20 modulates cadherin expression in ameloblasts as enamel develops.
    Authors: Guan X, Bartlett J
    2013-09-25;92(0):.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  61. EphrinB2 reverse signaling protects against capillary rarefaction and fibrosis after kidney injury.
    Authors: Kida Y, Ieronimakis N, Schrimpf C, Reyes M, Duffield J
    J Am Soc Nephrol, 2013-03-14;24(4):559-72.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: IHC
  62. A critical role for TLR4 induction of autophagy in the regulation of enterocyte migration and the pathogenesis of necrotizing enterocolitis.
    Authors: Neal M, Sodhi C, Dyer M, Craig B, Good M, Jia H, Yazji I, Afrazi A, Richardson W, Beer-Stolz D, Ma C, Prindle T, Grant Z, Branca M, Ozolek J, Hackam D
    J Immunol, 2013-03-01;190(7):3541-51.
    Species: Human
    Sample Types: Whole Cells
    Applications: IHC
  63. N-cadherin+ HSCs in fetal liver exhibit higher long-term bone marrow reconstitution activity than N-cadherin- HSCs.
    Biochem Biophys Res Commun, 2012-10-22;428(3):354-9.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: Flow Cytometry, IHC-Fr
  64. Remodeling of the lymphatic vasculature during mouse mammary gland morphogenesis is mediated via epithelial-derived lymphangiogenic stimuli.
    Authors: Betterman K, Paquet-Fifield S, Asselin-Labat M, Visvader J, Butler L, Stacker S, Achen M, Harvey N
    Am J Pathol, 2012-10-11;181(6):2225-38.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  65. Epithelial cell-intrinsic notch signaling plays an essential role in the maintenance of gut immune homeostasis.
    Authors: Obata Y, Takahashi D, Ebisawa M, Kakiguchi K, Yonemura S, Jinnohara T, Kanaya T, Fujimura Y, Ohmae M, Hase K, Ohno H
    J. Immunol., 2012-01-25;188(5):2427-36.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  66. Noninvasive assessment of antenatal hydronephrosis in mice reveals a critical role for Robo2 in maintaining anti-reflux mechanism.
    Authors: Wang H, Li Q, Liu J
    PLoS ONE, 2011-09-20;6(9):e24763.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  67. Effect of inhibition of vascular endothelial growth factor signaling on distribution of extravasated antibodies in tumors.
    Authors: Nakahara T, Norberg SM, Shalinsky DR, Hu-Lowe DD, McDonald DM
    Cancer Res., 2006-02-01;66(3):1434-45.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  68. FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons.
    Authors: Grieshammer U, Cebrian C, Ilagan R, Meyers E, Herzlinger D, Martin GR
    Development, 2005-07-27;132(17):3847-57.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  69. Multifunctionality of PAI-1 in fibrogenesis: evidence from obstructive nephropathy in PAI-1-overexpressing mice.
    Authors: Matsuo S, Lopez-Guisa JM, Cai X, Okamura DM, Alpers CE, Bumgarner RE, Peters MA, Zhang G, Eddy AA
    Kidney Int., 2005-06-01;67(6):2221-38.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr, IHC-P

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Human/Mouse E-Cadherin Antibody
By Armen Petrosyan on 04/01/2022
Application: IHC Sample Tested: Prostate tissue Species: Human
Immunohistochemistry Human/Mouse E-Cadherin Antibody AF748
Human/Mouse E-Cadherin Antibody
By Armen Petrosyan on 04/01/2022
Application: IHC Sample Tested: Mice prostate tissue Species: Mice prostate tissue and Mouse
Immunohistochemistry Human/Mouse E-Cadherin Antibody AF748
Human/Mouse E-Cadherin Antibody
By Anonymous on 09/22/2021
Application: ICC/IF Sample Tested: Skin tissue Species: Human
Immunocytochemistry/Immunofluorescence Human/Mouse E-Cadherin Antibody AF748
Human/Mouse E-Cadherin Antibody
By Chang Xie on 03/21/2019
Application: ICC/IF Sample Tested: Embryonic lung Species: Mouse
Human/Mouse E-Cadherin Antibody
By Anonymous on 01/14/2019
Application: ICC/IF Sample Tested: RT4-D6P2T rat schwannoma cell line Species: Human
Immunocytochemistry/Immunofluorescence Human/Mouse E-Cadherin Antibody AF748
Human/Mouse E-Cadherin Antibody
By Leslie Priddy on 04/13/2018
Application: IHC Sample Tested: Tumor cell lyastes Species: Mouse
Human/Mouse E-Cadherin Antibody
By simon liu on 12/19/2017
Application: ICC/IF Sample Tested: Bladder cancer tissue Species: Human
Immunocytochemistry/Immunofluorescence Human/Mouse E-Cadherin Antibody AF748
Human/Mouse E-Cadherin Antibody
By Preethi Vijayaraj on 09/27/2017
Application: ICC/IF Sample Tested: iPSC derived epithelial cells Species: Human
Immunocytochemistry/Immunofluorescence Human/Mouse E-Cadherin Antibody AF748
Human/Mouse E-Cadherin Antibody
By Anonymous on 07/31/2017
Application: WB Sample Tested: 293T human embryonic kidney cell line Species: Human
Human/Mouse E‑Cadherin Antibody
By Anonymous on 04/21/2016
Application: WB Sample Tested: mouse primary brain cell cultures Species: Mouse

Ab concentration: 0.1 ug/ml

Western Blot Human/Mouse E‑Cadherin Antibody AF748