Human/Mouse Myeloperoxidase/MPO Antibody Summary
Met16-Thr718
Accession # P11247
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
![Detection of Human/Mouse Myeloperoxidase/MPO antibody by Western Blot. Detection of Human/Mouse Myeloperoxidase/MPO antibody by Western Blot.](https://aeroglobalimagesuat.blob.core.windows.net/images/datasheets/antibody/Myeloperoxidase_AF3667_Western_Blot_5321.jpg)
Detection of Human/Mouse Myeloperoxidase/MPO by Western Blot. Western blot shows lysates of HL-60 human acute promyelocytic leukemia cell line, human neutrophil cells, and mouse spleen tissue. PVDF membrane was probed with 0.5 µg/mL of Goat Anti-Human/Mouse Myeloperoxidase/MPO Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3667) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF019). A specific band was detected for Myeloperoxidase/MPO at approximately 60 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 2.
![Myeloperoxidase/MPO antibody in Mouse Splenocytes by Immunocytochemistry (ICC). Myeloperoxidase/MPO antibody in Mouse Splenocytes by Immunocytochemistry (ICC).](https://aeroglobalimagesuat.blob.core.windows.net/images/datasheets/antibody/Myeloperoxidase_AF3667_Immunocytochemistry__Immunofluorescence_17390.jpg)
Myeloperoxidase/MPO in Mouse Splenocytes. Myeloperoxidase/MPO was detected in immersion fixed mouse splenocytes using Goat Anti-Human/Mouse Myeloperoxidase/MPO Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3667) at 15 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; NL001) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for Fluorescent ICC Staining of Non-adherent Cells.
![Myeloperoxidase/MPO antibody in Mouse Spleen Tissue by Immunohistochemistry (IHC-P). Myeloperoxidase/MPO antibody in Mouse Spleen Tissue by Immunohistochemistry (IHC-P).](https://aeroglobalimagesuat.blob.core.windows.net/images/datasheets/antibody/af3667_human-mouse-myeloperoxidase-affinity-purified-polyclonal-ab-immunohistochemistry-35202017739.jpg)
Myeloperoxidase/MPO in Mouse Spleen Tissue. Myeloperoxidase/MPO was detected in immersion fixed paraffin-embedded sections of mouse spleen tissue using Goat Anti-Human/Mouse Myeloperoxidase/MPO Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3667) at 1 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (VC004). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to lymphocytes. Staining was performed using our IHC Staining with VisUCyte HRP Polymer Detection Reagents.
![Detection of Mouse Myeloperoxidase/MPO antibody by Simple Western<SUP>TM</SUP>. Detection of Mouse Myeloperoxidase/MPO antibody by Simple Western<SUP>TM</SUP>.](https://aeroglobalimagesuat.blob.core.windows.net/images/datasheets/antibody/Myeloperoxidase_AF3667_Simple_Western_16637.jpg)
Detection of Mouse Myeloperoxidase/MPO by Simple WesternTM. Simple Western lane view shows lysates of mouse spleen tissue, loaded at 0.2 mg/mL. A specific band was detected for Myeloperoxidase/MPO at approximately 67 kDa (as indicated) using 5 µg/mL of Goat Anti-Human/Mouse Myeloperoxidase/MPO Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3667) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF109). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Myeloperoxidase/MPO
Myeloperoxidase (MPO) is a hemeprotein that belongs to the XPO subfamily of the heme peroxidase superfamily. MPO is synthesized as a preproprotein that undergoes proteolytic processing to generate a disulfide-linked heterodimer of the N-terminal beta -subunit (12 kDa) and C-terminal alpha subunit (60 kDa). Active MPO is a tetramer of two beta -subunits and two alpha -subunits that are also disulfide-linked through the two alpha -subunits. MPO is stored in granules and is an abundant protein in neutrophils and monocytes. MPO is released upon activation to catalyze the formation of powerful oxidants such as hypochlorous acid, which kills microbes. Unprocessed pro-MPO can also be released. Mouse MPO shares 87% amino acid sequence identity with that of human MPO.
Product Datasheets
Citations for Human/Mouse Myeloperoxidase/MPO Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer
Authors: Bojmar, L;Zambirinis, CP;Hernandez, JM;Chakraborty, J;Shaashua, L;Kim, J;Johnson, KE;Hanna, S;Askan, G;Burman, J;Ravichandran, H;Zheng, J;Jolissaint, JS;Srouji, R;Song, Y;Choubey, A;Kim, HS;Cioffi, M;van Beek, E;Sigel, C;Jessurun, J;Velasco Riestra, P;Blomstrand, H;Jönsson, C;Jönsson, A;Lauritzen, P;Buehring, W;Ararso, Y;Hernandez, D;Vinagolu-Baur, JP;Friedman, M;Glidden, C;Firmenich, L;Lieberman, G;Mejia, DL;Nasar, N;Mutvei, AP;Paul, DM;Bram, Y;Costa-Silva, B;Basturk, O;Boudreau, N;Zhang, H;Matei, IR;Hoshino, A;Kelsen, D;Sagi, I;Scherz, A;Scherz-Shouval, R;Yarden, Y;Oren, M;Egeblad, M;Lewis, JS;Keshari, K;Grandgenett, PM;Hollingsworth, MA;Rajasekhar, VK;Healey, JH;Björnsson, B;Simeone, DM;Tuveson, DA;Iacobuzio-Donahue, CA;Bromberg, J;Vincent, CT;O'Reilly, EM;DeMatteo, RP;Balachandran, VP;D'Angelica, MI;Kingham, TP;Allen, PJ;Simpson, AL;Elemento, O;Sandström, P;Schwartz, RE;Jarnagin, WR;Lyden, D;
Nature medicine
Species: Human
Sample Types: Whole Tissue
Applications: Immunohistochemistry -
Rapid NETosis Is an Effector Mechanism to Combat Ocular Herpes Infection
Authors: Patil, CD;Borase, H;Gagan, S;Sharma, P;Kapoor, D;Yadavalli, T;Jain, S;Joseph, J;Bagga, B;Shukla, D;
Investigative ophthalmology & visual science
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot -
Neutrophil extracellular traps formation may be involved in the association of propranolol with the development of portal vein thrombosis
Authors: Xu, X;Xu, S;Zhang, Y;Wang, L;Yan, C;Xu, Z;Zhao, Q;Qi, X;
Thrombosis research
Species: Mouse
Sample Types: Serum, Tissue Homogenates
Applications: Western Blot -
Toxicarioside H-mediated modulation of the immune microenvironment attenuates ovalbumin-induced allergic airway inflammation by inhibiting NETosis
Authors: Zhang, J;Huang, FY;Dai, SZ;Wang, L;Zhou, X;Zheng, ZY;Li, Q;Tan, GH;Wang, CC;
International immunopharmacology
Species: Mouse
Sample Types: Whole Tissue
Applications: Immunohistochemistry -
Foxp3+ Treg control allergic skin inflammation by restricting IFN-?-driven neutrophilic infiltration and NETosis
Authors: Tong, X;Kim, SH;Che, L;Park, J;Lee, J;Kim, TG;
Journal of dermatological science
Species: Transgenic Mouse, Mouse
Sample Types: Whole Cells, Whole Tissue
Applications: Immunohistochemistry, Immunocytochemistry -
The Elevated Inflammatory Status of Neutrophils Is Related to In-Hospital Complications in Patients with Acute Coronary Syndrome and Has Important Prognosis Value for Diabetic Patients
Authors: Barbu, E;Mihaila, AC;Gan, AM;Ciortan, L;Macarie, RD;Tucureanu, MM;Filippi, A;Stoenescu, AI;Petrea, SV;Simionescu, M;Balanescu, SM;Butoi, E;
International journal of molecular sciences
Species: Human
Sample Types: Cell Lysates, Whole Cells
Applications: Western Blot, Immunocytochemistry -
Modelling lung infection with Klebsiella pneumoniae after murine traumatic brain injury
Authors: Shad, A;Rewell, SSJ;Macowan, M;Gandasasmita, N;Wang, J;Chen, K;Marsland, B;O'Brien, TJ;Li, J;Semple, BD;
Journal of neuroinflammation
Species: Mouse
Sample Types: Whole Tissue
Applications: Immunohistochemistry -
Adjudin protects blood-brain barrier integrity and attenuates neuroinflammation following intracerebral hemorrhage in mice
Authors: Su, Q;Su, C;Zhang, Y;Guo, Y;Liu, Y;Liu, Y;Yong, VW;Xue, M;
International immunopharmacology
Species: Mouse
Sample Types: Whole Tissue
Applications: Immunohistochemistry -
TGF-?-driven LIF expression influences neutrophil extracellular traps (NETs) and contributes to peritoneal metastasis in gastric cancer
Authors: Zhang, F;Yan, Y;Cao, X;Guo, C;Wang, K;Lv, S;
Cell death & disease
Species: Human hepegivirus
Sample Types: Serum, Ascites Fluid, Whole Tissue
Applications: Immunohistochemistry, ELISA Capture -
Tamm-Horsfall protein augments neutrophil NETosis during urinary tract infection
Authors: Mercado-Evans, V;Chew, C;Serchejian, C;Saltzman, A;Mejia, ME;Zulk, JJ;Cornax, I;Nizet, V;Patras, KA;
bioRxiv : the preprint server for biology
Species: Viral, Murine polyomavirus strain A3
Sample Types: Whole Cells
Applications: Immunocytochemistry -
Chronic pulmonary bacterial infection facilitates breast cancer lung metastasis by recruiting tumor-promoting MHCII(hi) neutrophils
Authors: Ma T, Tang Y, Wang T et al.
Signal Transduction and Targeted Therapy
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Inhibition of SARS-CoV-2-mediated thromboinflammation by CLEC2.Fc
Authors: Sung, PS;Sun, CP;Tao, MH;Hsieh, SL;
EMBO molecular medicine
Species: Mouse, Human
Sample Types: Whole Tissue, Whole Cells
Applications: Immunocytochemistry, Immunohistochemistry -
Blockade of neutrophil extracellular traps ameliorates toluene diisocyanate-induced steroid-resistant asthma
Authors: X Peng, Y Li, W Zhao, S Yang, J Huang, Y Chen, Y Wang, Z Gong, X Chen, C Yu, S Cai, H Zhao
International immunopharmacology, 2023-02-22;117(0):109719.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Mice inflammatory responses to inhaled aerosolized LPS: effects of various forms of human alpha1-antitrypsin
Authors: K Sivaraman, S Wrenger, B Liu, D Schaudien, C Hesse, G Gomez-Mari, S Perez-Luz, K Sewald, D DeLuca, MJ Wurm, P Pino, T Welte, B Martinez-D, S Janciauski
Journal of leukocyte biology, 2023-01-10;113(1):58-70.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
IL-1beta neutralization prevents diastolic dysfunction development, but lacks hepatoprotective effect in an aged mouse model of NASH
Authors: D Kucsera, VE Tóth, NV Sayour, T Kovács, TG Gergely, M Ruppert, T Radovits, A Fábián, A Kovács, B Merkely, P Ferdinandy, ZV Varga
Scientific Reports, 2023-01-07;13(1):356.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Inhibition of neutrophil elastase prevents cigarette smoke exposure-induced formation of neutrophil extracellular traps and improves lung function in a mouse model of chronic obstructive pulmonary disease
Authors: K Wang, Y Liao, X Li, R Wang, Z Zeng, M Cheng, L Gao, D Xu, F Wen, T Wang, J Chen
International immunopharmacology, 2022-12-07;114(0):109537.
Species: Human
Sample Types: Whole Cell
Applications: ICC -
A novel phosphocholine-mimetic inhibits a pro-inflammatory conformational change in C-reactive protein
Authors: J Zeller, KS Cheung Tun, TL Nero, JD McFadyen, G Krippner, B Bogner, S Kreuzaler, J Kiefer, VK Horner, D Braig, H Danish, S Baratchi, M Fricke, X Wang, MG Kather, B Kammerer, KJ Woollard, P Sharma, CJ Morton, G Pietersz, MW Parker, K Peter, SU Eisenhardt
Embo Molecular Medicine, 2022-12-05;0(0):e16236.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Scavenging dicarbonyls with 5'-O-pentyl-pyridoxamine increases HDL net cholesterol efflux capacity and attenuates atherosclerosis and insulin resistance
Authors: J Huang, H Tao, PG Yancey, Z Leuthner, LS May-Zhang, JY Jung, Y Zhang, L Ding, V Amarnath, D Liu, S Collins, SS Davies, MF Linton
Molecular Metabolism, 2022-12-05;67(0):101651.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Platelet-Neutrophil Association in NETs-Rich Areas in the Retrieved AIS Patient Thrombi
Authors: GJ Pir, A Parray, R Ayadathil, SV Pananchikk, FA Mir, I Muhammad, A Abubakar, N Amir, S Hussain, KH Haroon, A Muhammad, Y Imam, SN Patro, N Akhtar, A Zakaria, S Kamran
International Journal of Molecular Sciences, 2022-11-21;23(22):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
KDM6A Loss Recruits Tumor-Associated Neutrophils and Promotes Neutrophil Extracellular Trap Formation in Pancreatic Cancer
Authors: J Yang, L Jin, HS Kim, F Tian, Z Yi, K Bedi, M Ljungman, M Pasca di M, H Crawford, J Shi
Cancer Research, 2022-11-15;0(0):OF1-OF14.
Species: Human, Mouse
Sample Types: Whole Cells, Whole Tissue
Applications: ICC, IHC -
CLEC5A is critical in Pseudomonas aeruginosa-induced acute lung injury
Authors: PS Sung, YC Peng, SP Yang, CH Chiu, SL Hsieh
JCI Insight, 2022-09-01;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Epigallocatechin-3-gallate reduces neutrophil extracellular trap formation and tissue injury in severe acute pancreatitis
Authors: H Li, C Qiao, L Zhao, Q Jing, D Xue, Y Zhang
Journal of leukocyte biology, 2022-08-19;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Integrating network pharmacology and transcriptomic validation to investigate the efficacy and mechanism of Mufangji decoction preventing lung cancer
Authors: F Gao, Y Niu, L Sun, W Li, H Xia, Y Zhang, S Geng, Z Guo, H Lin, G Du
Journal of ethnopharmacology, 2022-07-30;0(0):115573.
Species: Mouse
Sample Types: Whole Cells
Applications: ICC/IF -
Dysfunctional ERG signaling drives pulmonary vascular aging and persistent fibrosis
Authors: N Caporarell, J Lee, TX Pham, DL Jones, J Guan, PA Link, JA Meridew, G Marden, T Yamashita, CA Osborne, AV Bhagwate, SK Huang, RF Nicosia, DJ Tschumperl, M Trojanowsk, G Ligresti
Nature Communications, 2022-07-25;13(1):4170.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Neutrophil Extracellular Traps Promote NLRP3 Inflammasome Activation and Glomerular Endothelial Dysfunction in Diabetic Kidney Disease
Authors: A Gupta, K Singh, S Fatima, S Ambreen, S Zimmermann, R Younis, S Krishnan, R Rana, I Gadi, C Schwab, R Biemann, K Shahzad, V Rani, S Ali, PR Mertens, S Kohli, B Isermann
Nutrients, 2022-07-20;14(14):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
High PANX1 Expression Leads to Neutrophil Recruitment and the Formation of a High Adenosine Immunosuppressive Tumor Microenvironment in Basal-like Breast Cancer
Authors: W Chen, B Li, F Jia, J Li, H Huang, C Ni, W Xia
Cancers, 2022-07-11;14(14):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Deficiency of leukocyte-specific protein 1 (LSP1) alleviates asthmatic inflammation in a mouse model
Authors: NPK Le, AF do Nascime, D Schneberge, CC Quach, X Zhang, GK Aulakh, W Dawicki, L Liu, JR Gordon, B Singh
Respiratory Research, 2022-06-22;23(1):165.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Neutrophil Extracellular Traps Mediate Acute Liver Failure in Regulation of miR-223/neutrophil Elastase Signaling in Mice
Authors: D Ye, J Yao, W Du, C Chen, Y Yang, K Yan, J Li, Y Xu, S Zang, Y Zhang, X Rong, R Zhang, A Xu, J Guo
Cellular and Molecular Gastroenterology and Hepatology, 2022-06-02;0(0):.
Species: Mouse
Sample Types: Tissue Homogenates, Whole Cells, Whole Tissue
Applications: ICC, IHC, Western Blot -
Depletion of gammadelta T Cells Leads to Reduced Angiogenesis and Increased Infiltration of Inflammatory M1-like Macrophages in Ischemic Muscle Tissue
Authors: C Arnholdt, K Kumaraswam, P Götz, M Kübler, M Lasch, E Deindl
Cells, 2022-04-29;11(9):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Disulfiram inhibits neutrophil extracellular trap formation protecting rodents from acute lung injury and SARS-CoV-2 infection
Authors: JM Adrover, L Carrau, J Da beta ler-Ple, Y Bram, V Chandar, S Houghton, D Redmond, JR Merrill, M Shevik, BR tenOever, SK Lyons, RE Schwartz, M Egeblad
JCI Insight, 2022-03-08;0(0):.
Species: Hamster
Sample Types: Whole Tissue
Applications: IHC -
Blocking the human common beta subunit of the GM-CSF, IL-5 and IL-3 receptors markedly reduces hyperinflammation in ARDS models
Authors: H Wang, DJ Tumes, TR Hercus, KH Yip, C Aloe, R Vlahos, AF Lopez, N Wilson, CM Owczarek, S Bozinovski
Cell Death & Disease, 2022-02-10;13(2):137.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
ADAM8 signaling drives neutrophil migration and ARDS severity
Authors: C Conrad, D Yildiz, SJ Cleary, A Margraf, L Cook, U Schlomann, B Panaretou, JL Bowser, H Karmouty-Q, J Li, NK Berg, SC Martin, A Aljohmani, SF Moussavi-H, KM Wang, JJ Tian, M Magnen, C Valet, L Qiu, JP Singer, HK Eltzschig, CAPSys Stu, W Bertrams, S Herold, N Suttorp, B Schmeck, ZT Ball, A Zarbock, MR Looney, JW Bartsch
JCI Insight, 2022-02-08;7(3):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
CXCR4 and CXCR7 Inhibition Ameliorates the Formation of Platelet-Neutrophil Complexes and Neutrophil Extracellular Traps through Adora2b Signaling
Authors: KC Ngamsri, RA Putri, C Jans, K Schindler, A Fuhr, Y Zhang, J Gamper-Tsi, S Ehnert, FM Konrad
International Journal of Molecular Sciences, 2021-12-17;22(24):.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Modulation of Cellular NAD+ Attenuates Cancer-Associated Hypercoagulability and Thrombosis via the Inhibition of Tissue Factor and Formation of Neutrophil Extracellular Traps
Authors: W Cao, MY Zhu, SH Lee, SB Lee, HJ Kim, BO Park, CH Yoon, D Khadka, GS Oh, H Shim, TH Kwak, HS So
International Journal of Molecular Sciences, 2021-11-08;22(21):.
Species: Mouse
Sample Types: Whole Cells
Applications: IHC -
Eosinophil extracellular traps drive asthma progression through neuro-immune signals
Authors: Y Lu, Y Huang, J Li, J Huang, L Zhang, J Feng, J Li, Q Xia, Q Zhao, L Huang, S Jiang, S Su
Nature Cell Biology, 2021-10-06;23(10):1060-1072.
Species: Mouse
Sample Types: BALF, Whole Cells
Applications: ICC -
Sprague Dawley Rats Gaining Weight on a High Energy Diet Exhibit Damage to Taste Tissue Even after Return to a Healthy Diet
Authors: F Harnischfe, F O'Connell, M Weiss, B Axelrod, A Hajnal, K Czaja, PM Di Lorenzo, R Dando
Nutrients, 2021-08-31;13(9):.
Species: Rat
Sample Types: Whole Tissue
Applications: IHC -
ELMO1 signaling is a promoter of osteoclast function and bone loss
Authors: S Arandjelov, JSA Perry, M Zhou, A Ceroi, I Smirnov, SF Walk, LS Shankman, I Cambré, S Onengut-Gu, D Elewaut, TP Conrads, KS Ravichandr
Nature Communications, 2021-08-17;12(1):4974.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot -
Evidence of a Myenteric Plexus Barrier and Its Macrophage-Dependent Degradation During Murine Colitis: Implications in Enteric Neuroinflammation
Authors: D Dora, S Ferenczi, R Stavely, VE Toth, ZV Varga, T Kovacs, I Bodi, R Hotta, KJ Kovacs, AM Goldstein, N Nagy
Cellular and Molecular Gastroenterology and Hepatology, 2021-07-08;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
AMPK hyperactivation promotes dendrite retraction, synaptic loss, and neuronal dysfunction in glaucoma
Authors: N Belforte, J Agostinone, L Alarcon-Ma, D Villafranc, F Dotigny, JL Cueva Varg, A Di Polo
Molecular Neurodegeneration, 2021-06-29;16(1):43.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
NETosis in the pathogenesis of acute lung injury following cutaneous chemical burns
Authors: R Surolia, FJ Li, Z Wang, M Kashyap, RK Srivastava, AM Traylor, P Singh, KG Dsouza, H Kim, JF Pittet, JW Zmijewski, A Agarwal, M Athar, A Ahmad, VB Antony
JCI Insight, 2021-05-24;6(10):.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Absence of Cold-Inducible RNA-Binding Protein (CIRP) Promotes Angiogenesis and Regeneration of Ischemic Tissue by Inducing M2-Like Macrophage Polarization
Authors: M Kübler, S Beck, S Fischer, P Götz, K Kumaraswam, H Ishikawa-A, M Lasch, E Deindl
Biomedicines, 2021-04-07;9(4):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Hsp90-stabilized MIF supports tumor progression via macrophage recruitment and angiogenesis in colorectal cancer
Authors: L Klemke, T De Oliveir, D Witt, N Winkler, H Bohnenberg, R Bucala, LC Conradi, R Schulz-Hed
Cell Death & Disease, 2021-02-04;12(2):155.
Species: Mouse
Sample Types: Organoid
Applications: IHC -
Immunomodulatory role of reactive oxygen species and nitrogen species during T cell-driven neutrophil-enriched acute and chronic cutaneous delayed-type hypersensitivity reactions
Authors: R Mehling, J Schwenck, C Lemberg, C Trautwein, L Zizmare, D Kramer, A Müller, B Fehrenbach, I Gonzalez-M, L Quintanill, K Schröder, RP Brandes, M Schaller, W Ruf, M Eichner, K Ghoreschi, M Röcken, BJ Pichler, M Kneilling
Theranostics, 2021-01-01;11(2):470-490.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Suppression of Metastatic Melanoma Growth in Lung by Modulated Electro-Hyperthermia Monitored by a Minimally Invasive Heat Stress Testing Approach in Mice
Authors: MJ Thomas, E Major, A Benedek, I Horváth, D Máthé, R Bergmann, AM Szász, T Krenács, Z Benyó
Cancers, 2020-12-21;12(12):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Alveolar barrier disruption in varicella pneumonia is associated with neutrophil extracellular trap formation
Authors: WJ Ouwendijk, HJ van den Ha, MW Delany, JJ van Kampen, GP van Nierop, T Mehraban, F Zaaraoui-B, WF van IJcken, JM van den Br, RD De Vries, AC Andeweg, GM Verjans
JCI Insight, 2020-11-05;0(0):.
Species: Primate
Sample Types: Whole Tissue
Applications: IHC -
Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis
Authors: L Moreira-Te, PJ Stimpson, E Stavropoul, S Hadebe, P Chakravart, M Ioannou, IV Aramburu, E Herbert, SL Priestnall, A Suarez-Bon, J Sousa, KL Fonseca, Q Wang, S Vashakidze, P Rodríguez-, C Vilaplana, M Saraiva, V Papayannop, A O'Garra
Nat Commun, 2020-11-04;11(1):5566.
Species: Mouse
Sample Types: Whole Cells
Applications: ICC -
Immunohistological Analysis of Neutrophils and Neutrophil Extracellular Traps in Human Thrombemboli Causing Acute Ischemic Stroke
Authors: F Essig, AM Kollikowsk, M Pham, L Solymosi, G Stoll, KG Haeusler, P Kraft, MK Schuhmann
Int J Mol Sci, 2020-10-07;21(19):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
The Metalloproteinase ADAMTS5 Is Expressed by Interstitial Inflammatory Cells in IgA Nephropathy and Is Proteolytically Active on the Kidney Matrix
Authors: S Taylor, M Whitfield, J Barratt, A Didangelos
J. Immunol., 2020-09-11;0(0):.
Species: Human, Rat
Sample Types: Cell Lysates, Tissue Homogenates, Whole Tissue
Applications: IHC, Western Blot -
Neutrophil Extracellular Traps Impair Intestinal Barrier Function during Experimental Colitis
Authors: EY Lin, HJ Lai, YK Cheng, KQ Leong, LC Cheng, YC Chou, YC Peng, YH Hsu, HS Chiang
Biomedicines, 2020-08-05;8(8):.
Species: Mouse
Sample Types: Cell Lysates, Tissue Homogenates, Whole Tissue
Applications: ELISA Capture, IHC -
Neutrophil extracellular traps exacerbate neurological deficits after traumatic brain injury
Authors: K Vaibhav, M Braun, K Alverson, H Khodadadi, A Kutiyanawa, A Ward, C Banerjee, T Sparks, A Malik, MH Rashid, MB Khan, MF Waters, DC Hess, AS Arbab, JR Vender, N Hoda, B Baban, KM Dhandapani
Sci Adv, 2020-05-29;6(22):eaax8847.
Species: Mouse
Sample Types: Whole Cells
Applications: ICC -
Histones, DNA, and Citrullination Promote Neutrophil Extracellular Trap Inflammation by Regulating the Localization and Activation of TLR4
Authors: TD Tsouroukts, A Warnatsch, M Ioannou, D Hoving, Q Wang, V Papayannop
Cell Rep, 2020-05-05;31(5):107602.
Species: Human, Mouse
Sample Types: Cell Lysates
Applications: Western Blot -
Therapeutic ACPA inhibits NET formation: a potential therapy for neutrophil-mediated inflammatory diseases
Authors: RGS Chirivi, JWG van Rosmal, M van der Li, M Euler, G Schmets, G Bogatkevic, K Kambas, J Hahn, Q Braster, O Soehnlein, MH Hoffmann, HHGV Es, JMH Raats
Cell. Mol. Immunol., 2020-03-20;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Deficiency in the glycosyltransferase Gcnt1 increases susceptibility to tuberculosis through a mechanism involving neutrophils
Authors: KL Fonseca, AR Maceiras, R Matos, L Simoes-Cos, J Sousa, B Cá, L Barros, AI Fernandes, S Mereiter, R Reis, J Gomes, G Tapia, P Rodríguez-, M Martín-Cés, S Vashakidze, S Gogishvili, K Nikolaishv, R Appelberg, F Gärtner, PNS Rodrigues, C Vilaplana, CA Reis, A Magalhães, M Saraiva
Mucosal Immunol, 2020-03-13;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Programmed 'disarming' of the neutrophil proteome reduces the magnitude of inflammation
Authors: JM Adrover, A Aroca-Crev, G Crainiciuc, F Ostos, Y Rojas-Vega, A Rubio-Ponc, C Cilloniz, E Bonzón-Kul, E Calvo, D Rico, MA Moro, C Weber, I Lizasoaín, A Torres, J Ruiz-Cabel, J Vázquez, A Hidalgo
Nat. Immunol., 2020-01-13;21(2):135-144.
Species: Human
Sample Types: Whole Cells
Applications: Functional Assay -
Keratinocyte-derived I&kappaB? drives psoriasis and associated systemic inflammation
Authors: S Lorscheid, A Müller, J Löffler, C Resch, P Bucher, FC Kurschus, A Waisman, K Schäkel, S Hailfinger, K Schulze-Os, D Kramer
JCI Insight, 2019-11-14;4(22):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Acute Liver Injury after CCl4 Administration is Independent of Smad7 Expression in Myeloid Cells
Authors: J Endig, L Unrau, P Sprezyna, S Rading, M Karsak, D Goltz, LC Heukamp, G Tiegs, L Diehl
Int J Mol Sci, 2019-11-06;20(22):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Locally instructed CXCR4hi neutrophils trigger environment-driven allergic asthma through the release of neutrophil extracellular traps
Authors: C Radermecke, C Sabatel, C Vanwinge, C Ruscitti, P Maréchal, F Perin, J Schyns, N Rocks, M Toussaint, D Cataldo, SL Johnston, F Bureau, T Marichal
Nat. Immunol., 2019-10-07;0(0):.
Species: Mouse
Sample Types: Whole Cells, Whole Tissue
Applications: ICC, IHC -
Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors
Authors: K Bitschar, B Sauer, J Focken, H Dehmer, S Moos, M Konnerth, NA Schilling, S Grond, H Kalbacher, FC Kurschus, F Götz, B Krismer, A Peschel, B Schittek
Nat Commun, 2019-06-21;10(1):2730.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2
Authors: PS Sung, TF Huang, SL Hsieh
Nat Commun, 2019-06-03;10(1):2402.
Species: Human, Mouse
Sample Types: Whole Cells, Whole Tissue
Applications: ICC, IHC -
Tofacitinib enhances delivery of antibody-based therapeutics to tumor cells through modulation of inflammatory cells
Authors: N Simon, A Antignani, SM Hewitt, M Gadina, C Alewine, D FitzGerald
JCI Insight, 2019-03-07;0(0):.
Species: Xenograft
Sample Types: Whole Tissue
Applications: IHC-P -
Neutrophils escort circulating tumour cells to enable cell cycle progression
Authors: BM Szczerba, F Castro-Gin, M Vetter, I Krol, S Gkountela, J Landin, MC Scheidmann, C Donato, R Scherrer, J Singer, C Beisel, C Kurzeder, V Heinzelman, C Rochlitz, WP Weber, N Beerenwink, N Aceto
Nature, 2019-02-06;0(0):.
Species: Mouse
Sample Types: Whole Cells, Whole Tissue
Applications: ICC, IHC -
Qingnao dripping pills mediate immune-inflammatory response and MAPK signaling pathway after acute ischemic stroke in rats
Authors: Z Zeng, Y Zhang, X Liang, F Wang, J Zhao, Z Xu, X Liu, X Liu
J. Pharmacol. Sci., 2019-01-22;0(0):.
Species: Rat
Sample Types: Tissue Homogenates, Whole Tissue
Applications: IHC, Western Blot -
Matrix metalloproteinase-9 deficiency protects mice from severe influenza A viral infection
Authors: J Rojas-Quin, X Wang, J Tipper, PR Burkett, J Zuñiga, AR Ashtekar, F Polverino, A Rout, I Yambayev, C Hernández, L Jimenez, G Ramírez, KS Harrod, CA Owen
JCI Insight, 2018-12-20;3(24):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
GWAS for Interleukin-1? levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation
Authors: S Offenbache, Y Jiao, SJ Kim, J Marchesan, KL Moss, L Jing, K Divaris, S Bencharit, CS Agler, T Morelli, S Zhang, L Sun, WT Seaman, D Cowley, SP Barros, JD Beck, M Munz, AS Schaefer, KE North
Nat Commun, 2018-09-11;9(1):3686.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Mesenchymal stem cells attenuate blood-brain barrier leakage after cerebral ischemia in mice
Authors: Z Cheng, L Wang, M Qu, H Liang, W Li, Y Li, L Deng, Z Zhang, GY Yang
J Neuroinflammation, 2018-05-03;15(1):135.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Reg3? is associated with cardiac inflammation and provides prognostic information in patients with acute coronary syndrome
Authors: H Lörchner, C Widera, Y Hou, A Elsässer, H Warnecke, E Giannitsis, JS Hulot, T Braun, KC Wollert, J Pöling
Int. J. Cardiol., 2018-05-01;258(0):7-13.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot -
Cell-penetrating interactomic inhibition of nuclear factor-kappa B in a mouse model of postoperative cognitive dysfunction
Authors: SY Cheon, JM Kim, EH Kam, CC Ho, EJ Kim, S Chung, JH Jeong, DD Lee, SW Lee, BN Koo
Sci Rep, 2017-10-18;7(1):13482.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Topical Fibronectin Improves Wound Healing of Irradiated Skin
Authors: MB Johnson, B Pang, DJ Gardner, S Niknam-Ben, V Soundaraja, A Bramos, DP Perrault, K Banks, GK Lee, RY Baker, GH Kim, S Lee, Y Chai, M Chen, W Li, L Kwong, YK Hong, AK Wong
Sci Rep, 2017-06-20;7(1):3876.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
The blood-borne sialyltransferase ST6Gal-1 is a negative systemic regulator of granulopoiesis
Authors: CWL Dougher, A Buffone, MJ Nemeth, M Nasirikena, EE Irons, PN Bogner, JTY Lau
J. Leukoc. Biol., 2017-05-26;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot -
Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation
Authors: M Toussaint, DJ Jackson, D Swieboda, A Guedán, TD Tsouroukts, YM Ching, C Radermecke, H Makrinioti, J Aniscenko, MR Edwards, R Solari, F Farnir, V Papayannop, F Bureau, T Marichal, SL Johnston
Nat. Med., 2017-05-01;23(6):681-691.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Obesity promotes prolonged ovalbumin-induced airway inflammation modulating Th1, Th2 and Th17 immune responses in BALB/c mice
Authors: FM Silva, EE Oliveira, AC Gouveia, AS Brugiolo, CC Alves, JO Correa, J Gameiro, J Mattes, HC Teixeira, AP Ferreira
Clin. Exp. Immunol, 2017-03-31;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Swimming Motility Mediates the Formation of Neutrophil Extracellular Traps Induced by Flagellated Pseudomonas aeruginosa
PLoS Pathog., 2016-11-17;12(11):e1005987.
Species: Mouse
Sample Types: Whole Cells
Applications: IHC -
PAD4 Deficiency Decreases Inflammation and Susceptibility to Pregnancy Loss in a Mouse Model
Authors: Luise Erpenbeck
Biol. Reprod, 2016-11-09;95(6):132.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
Beneficial Effects of Sodium Phenylbutyrate Administration During Infection with Salmonella enterica serovar Typhimurium
Infect Immun, 2016-08-19;0(0):.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot -
Neutrophil Attack Triggers Extracellular Trap-Dependent Candida Cell Wall Remodeling and Altered Immune Recognition
PLoS Pathog, 2016-05-25;12(5):e1005644.
Species: Mouse
Sample Types: Whole Cells
Applications: IHC -
Rhadinovirus host entry by co-operative infection.
Authors: Lawler C, Milho R, May J, Stevenson P
PLoS Pathog, 2015-03-19;11(3):e1004761.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Correction: A chitin-like component on sclerotic cells of fonsecaea pedrosoi inhibits dectin-1-mediated murine Th17 development by masking beta-glucans.
PLoS ONE, 2015-03-18;10(3):e0119244.
Species: Mouse
Sample Types: Tissue Homogenates, Whole Tissue
Applications: IHC, Western Blot -
Lactobacillus rhamnosus GG and Bifidobacterium longum attenuate lung injury and inflammatory response in experimental sepsis.
Authors: Khailova L, Petrie B, Baird C, Dominguez Rieg J, Wischmeyer P
PLoS ONE, 2014-05-15;9(5):e97861.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
The cytokine IL-22 promotes pathogen colonization by suppressing related commensal bacteria.
Authors: Behnsen J, Jellbauer S, Wong C, Edwards R, George M, Ouyang W, Raffatellu M
Immunity, 2014-02-06;40(2):262-73.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot -
IL-33 targeting attenuates intestinal mucositis and enhances effective tumor chemotherapy in mice.
Authors: Guabiraba R, Besnard A, Menezes G, Secher T, Jabir M, Amaral S, Braun H, Lima-Junior R, Ribeiro R, Cunha F, Teixeira M, Beyaert R, Graham G, Liew F
Mucosal Immunol, 2014-01-15;7(5):1079-93.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Transcriptomic analysis of host immune and cell death responses associated with the influenza A virus PB1-F2 protein.
Authors: Le Goffic R, Leymarie O, Chevalier C, Rebours E, Da Costa B, Vidic J, Descamps D, Sallenave JM, Rauch M, Samson M, Delmas B
PLoS Pathog., 2011-08-25;7(8):e1002202.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr -
Tissue inhibitor of metalloproteinases 3 regulates resolution of inflammation following acute lung injury.
Authors: Gill SE, Huizar I, Bench EM
Am. J. Pathol., 2009-12-11;176(1):64-73.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: ELISA Development
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