Home / SOX1 / Human/Mouse/Rat SOX1 Antibody

Human/Mouse/Rat SOX1 Antibody

Catalog #: AF3369
64 Citations 4 Reviews Datasheet / COA / SDS
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AF3369
AF3369-SP
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Detection of Human SOX1 by Western Blot.
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Citations (64)
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Human/Mouse/Rat SOX1 Antibody Summary

Species Reactivity
Human, Mouse, Rat
Specificity
Detects human SOX1 in direct ELISAs and Western blots.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
E. coli-derived recombinant human SOX1
Asn242-Gly379 (Leu276Ile)
Accession # NP_005977
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
See below
Simple Western
10 µg/mL
See below
Immunohistochemistry
3-15 µg/mL
Immersion fixed paraffin-embedded sections of human brain (cortex)
Immunocytochemistry
5-15 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Human SOX1 antibody by Western Blot. View Larger

Detection of Human SOX1 by Western Blot. Western blot shows lysates of undifferentiated iBJ6 human iPS cells and iBJ6 human iPS cells differentiated into neuroprogenitor cells. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF017). A specific band was detected for SOX1 at approximately 39 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Immunocytochemistry SOX1 antibody in ectoderm differentuiated BG01V Human Embryonic Stem Cells by Immunocytochemistry (ICC). View Larger

SOX1 in ectoderm differentuiated BG01V Human Embryonic Stem Cells. SOX1 was detected in immersion fixed BG01V human embryonic stem cells differentiated into neural progenitor cells using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; NL001) and counterstained with DAPI (blue). Nestin was also detected using Mouse Anti-Mouse/Rat Nestin Monoclonal Antibody (MAB2736) and stained using the NorthernLights™ 493-conjugated Anti-Mouse IgG Secondary Antibody (green; Catalog # NL009). Specific staining of SOX1 was localized to nuclei. View our protocol for Fluorescent ICC Staining of Stem Cells on Coverslips.

Immunocytochemistry SOX1 antibody in differentiated NTera-2 Human Cell Line by Immunocytochemistry (ICC). View Larger

SOX1 in differentiated NTera‑2 Human Cell Line. SOX1 was detected in immersion fixed NTera-2 human testicular embryonic carcinoma cell line differentiated with retinoic acid using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 493-conjugated Anti-Goat IgG Secondary Antibody (green, upper panel; NL003) and counterstained with DAPI (blue, lower panel). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Immunocytochemistry SOX1 antibody in Rat Cortical Stem Cells by Immunocytochemistry (ICC). View Larger

SOX1 in Rat Cortical Stem Cells. SOX1 was detected in immersion fixed rat cortical stem cells (NSC001) using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red, upper panel; NL001) and counterstained with DAPI (blue, lower panel). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Immunocytochemistry SOX1 antibody in Mouse Cortical Stem Cells by Immunocytochemistry (ICC). View Larger

SOX1 in Mouse Cortical Stem Cells. SOX1 was detected in immersion fixed mouse cortical stem cells (Catalog # NSC002) using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red, upper panel; NL001) and counterstained with DAPI (blue, lower panel). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Immunohistochemistry View Larger

SOX1 in Human Brain (Cortex). SOX1 was detected in immersion fixed paraffin-embedded sections of human brain (cortex) using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 3 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Mouse IgG VisUCyte™ HRP Polymer Antibody (VC001). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to nuclei in neuron. Staining was performed using our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Simple Western Detection of Human SOX1 antibody by Simple Western<sup>TM</sup>. View Larger

Detection of Human SOX1 by Simple WesternTM. Simple Western lane view shows lysates of undifferentiated iBJ6 human iPS cells and iBJ6 human iPS cells differentiated into neuroprogenitor cells, loaded at 0.2 mg/mL. A specific band was detected for SOX1 at approximately 50 kDa (as indicated) using 10 µg/mL of Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF109). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: SOX1

SOX1 is a 39 kDa transcription factor that belongs to the SOXB1 subgroup. Within the developing CNS, SOX1 maintains neural cells in an undifferentiated state and has been used as a marker for neural stem cells. Human and mouse SOX1 share 97% amino acid sequence identity.

Long Name
SRY-related HMG-box 1
Entrez Gene IDs
6656 (Human); 20664 (Mouse)
Alternate Names
SOX1; SRY (sex determining region Y)-box 1; SRY-related HMG-box gene 1; transcription factor SOX-1

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Citations for Human/Mouse/Rat SOX1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

64 Citations: Showing 1 - 10
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  1. TREX tetramer disruption alters RNA processing necessary for corticogenesis in THOC6 Intellectual Disability Syndrome
    Authors: Werren, EA;LaForce, GR;Srivastava, A;Perillo, DR;Li, S;Johnson, K;Baris, S;Berger, B;Regan, SL;Pfennig, CD;de Munnik, S;Pfundt, R;Hebbar, M;Jimenez-Heredia, R;Karakoc-Aydiner, E;Ozen, A;Dmytrus, J;Krolo, A;Corning, K;Prijoles, EJ;Louie, RJ;Lebel, RR;Le, TL;Amiel, J;Gordon, CT;Boztug, K;Girisha, KM;Shukla, A;Bielas, SL;Schaffer, AE;
    Nature communications
    Species: Human hepegivirus, Murine polyomavirus strain A3
    Sample Types: Embryo, Organoid
    Applications: Immunohistochemistry
  2. Establishing a human-induced pluripotent stem cell line (SMUSHi003-A) from a patient with Charcot-Marie-Tooth disease and focal segmental glomerulosclerosis
    Authors: Lei, Q;Zhou, W;Huang, L;Zhang, Y;Xu, X;Guo, X;
    Stem cell research
    Species: Human hepegivirus
    Sample Types: Organoid
    Applications: Immunocytochemistry
  3. Generation of hiPSCs (JUCGRMi003-A) from a patient with Parkinson's disease with PARK2 mutation
    Authors: Ishikawa, KI;Okuzumi, A;Yoshino, H;Hattori, N;Akamatsu, W;
    Stem cell research
    Species: Human hepegivirus
    Sample Types: Whole Cells
    Applications: Immunocytochemistry
  4. Integrated transcriptome and proteome analysis reveals posttranscriptional regulation of ribosomal genes in human brain organoids
    Authors: J Sidhaye, P Trepte, N Sepke, M Novatchkov, M Schutzbier, G Dürnberger, K Mechtler, JA Knoblich
    Elife, 2023-03-29;12(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  5. Large-scale organoid study suggests effects of trisomy 21 on early fetal neurodevelopment are more subtle than variability between isogenic lines and experiments
    Authors: JT Czerminski, OD King, JB Lawrence
    Frontiers in Neuroscience, 2023-02-03;16(0):972201.
    Species: Human
    Sample Types: Organoid
    Applications: IHC
  6. ZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers
    Authors: R Yelagandul, K Stecher, M Novatchkov, L Michetti, G Michlits, J Wang, P Hofbauer, G Vainorius, C Pribitzer, L Isbel, S Mendjan, D Schübeler, U Elling, J Brennecke, O Bell
    Nature Cell Biology, 2023-01-05;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  7. Mutations in the transcriptional regulator MeCP2 severely impact key cellular and molecular signatures of human astrocytes during maturation
    Authors: J Sun, S Osenberg, A Irwin, LH Ma, N Lee, Y Xiang, F Li, YW Wan, IH Park, M Maletic-Sa, N Ballas
    Cell Reports, 2023-01-05;42(1):111942.
    Species: Human
    Sample Types: Organoid
    Applications: IHC
  8. Generation of a human iPSC line (CIBi014-A) from a patient with Parkinson's disease carrying a novel heterozygotic PARK8 (LRRK2) mutation
    Authors: L Li, X Si, J Yang, M Lei, H Liu, J Ruan, H Fu, W Li, H Yang, X Lei, H Sang
    Stem Cell Research, 2022-12-09;66(0):102995.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  9. Mispatterning and interneuron deficit in Tourette Syndrome basal ganglia organoids
    Authors: MV Brady, J Mariani, Y Koca, A Szekely, RA King, MH Bloch, A Landeros-W, JF Leckman, FM Vaccarino
    Molecular Psychiatry, 2022-11-29;0(0):.
    Species: Human
    Sample Types: Organoid
    Applications: IHC
  10. Generation and characterization of a human induced pluripotent stem cell (iPSC) line from a patient with congenital heart disease (CHD)
    Authors: H Lin, SQ Ye, ZH Xu, JS Penaloza, M Aljuhani, T Vetter, MT Zhao, KL McBride
    Stem Cell Research, 2022-10-31;65(0):102958.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  11. Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Promotes Forelimb Functional Recovery after Cervical Spinal Cord Injury
    Authors: Y Zheng, CM Gallegos, H Xue, S Li, DH Kim, H Zhou, X Xia, Y Liu, Q Cao
    Cells, 2022-09-05;11(17):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  12. Aberrant induction of p19Arf-mediated cellular senescence contributes to neurodevelopmental defects
    Authors: M Rhinn, I Zapata-Bod, A Klein, JL Plassat, T Knauer-Mey, WM Keyes
    PloS Biology, 2022-06-14;20(6):e3001664.
    Species: Human
    Sample Types: Organoids
    Applications: IHC
  13. Generation and characterization of a genetic Parkinson's disease-patient derived iPSC line DJ-1-delP (LCSBi008-A)
    Authors: P Mencke, I Boussaad, G Önal, AJA Kievit, AJW Boon, W Mandemaker, V Bonifati, R Krüger
    Stem Cell Research, 2022-04-26;62(0):102792.
    Species: Human
    Sample Types: Transfected Whole Cells
    Applications: ICC
  14. Generation of the human induced pluripotent stem cell line (IBKMOLi002-A) from PBMCs of a patient carrying the heterozygous L271H mutation of the voltage-gated calcium channel subunit Cav1.3-encoding CACNA1D gene
    Authors: M Tisch, M Carmen De, M Suarez-Cub, C Fauth, M Defrancesc, J Zschocke, K Günther, F Edenhofer
    Stem Cell Research, 2022-04-09;61(0):102784.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  15. BRN2 as a key gene drives the early primate telencephalon development
    Authors: X Zhu, Y Guo, C Chu, D Liu, K Duan, Y Yin, C Si, Y Kang, J Yao, X Du, J Li, S Zhao, Z Ai, Q Zhu, W Ji, Y Niu, T Li
    Science Advances, 2022-03-04;8(9):eabl7263.
    Species: Primate (Macaca fascicularis)
    Sample Types: Whole Tissue
    Applications: IHC
  16. G-quadruplex DNA structures in human stem cells and differentiation
    Authors: KG Zyner, A Simeone, SM Flynn, C Doyle, G Marsico, S Adhikari, G Portella, D Tannahill, S Balasubram
    Nature Communications, 2022-01-10;13(1):142.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  17. Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors
    Authors: HS Meharena, A Marco, V Dileep, ER Lockshin, GY Akatsu, J Mullahoo, LA Watson, T Ko, LN Guerin, F Abdurrob, S Rengarajan, M Papanastas, JD Jaffe, LH Tsai
    Cell Stem Cell, 2022-01-06;29(1):116-130.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  18. Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness
    Authors: T Pachano, V Sánchez-Ga, T Ealo, M Mariner-Fa, T Bleckwehl, HG Asenjo, P Respuela, S Cruz-Molin, M Muñoz-San, E Haro, WFJ van IJcken, D Landeira, A Rada-Igles
    Nature Genetics, 2021-06-28;53(7):1036-1049.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: IHC
  19. Derivation of iPSC line UMi029-A bearing a hearing-loss associated variant in the SMPX gene
    Authors: DM Dykxhoorn, X Tong, NC Gosstola, XZ Liu
    Stem Cell Research, 2021-05-24;54(0):102405.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  20. Donor cell memory confers a metastable state of directly converted cells
    Authors: KP Kim, C Li, D Bunina, HW Jeong, J Ghelman, J Yoon, B Shin, H Park, DW Han, JB Zaugg, J Kim, T Kuhlmann, RH Adams, KM Noh, SA Goldman, HR Schöler
    Cell Stem Cell, 2021-04-12;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  21. Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly
    Authors: V Krenn, C Bosone, TR Burkard, J Spanier, U Kalinke, A Calistri, C Salata, R Rilo Chris, P Pestana Ga, A Mirazimi, JA Knoblich
    Cell Stem Cell, 2021-04-09;0(0):.
    Species: Human
    Sample Types: Organoid
    Applications: IHC
  22. Human spinal GABA neurons alleviate spasticity and improve locomotion in rats with spinal cord injury
    Authors: C Gong, X Zheng, F Guo, Y Wang, S Zhang, J Chen, X Sun, SZA Shah, Y Zheng, X Li, Y Yin, Q Li, X Huang, T Guo, X Han, SC Zhang, W Wang, H Chen
    Cell Reports, 2021-03-23;34(12):108889.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: IHC
  23. A Human Induced Pluripotent Stem Cell-Derived Isogenic Model of Huntington's Disease Based on Neuronal Cells Has Several Relevant Phenotypic Abnormalities
    Authors: T Malankhano, L Suldina, E Grigor'eva, S Medvedev, J Minina, K Morozova, E Kiseleva, S Zakian, A Malakhova
    J Pers Med, 2020-11-09;10(4):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  24. Development of an ObLiGaRe Doxycycline Inducible Cas9 system for pre-clinical cancer drug discovery
    Authors: A Lundin, MJ Porritt, H Jaiswal, F Seeliger, C Johansson, AW Bidar, L Badertsche, S Wimberger, EJ Davies, E Hardaker, CP Martins, E James, T Admyre, A Taheri-Gha, J Bradley, A Schantz, B Alaeimahab, M Clausen, X Xu, LM Mayr, R Nitsch, M Bohlooly-Y, ST Barry, M Maresca
    Nat Commun, 2020-09-29;11(1):4903.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  25. A Shh/Gli-driven three-node timer motif controls temporal identity and fate of neural stem cells
    Authors: JM Dias, Z Alekseenko, A Jeggari, M Boareto, J Vollmer, M Kozhevniko, H Wang, MP Matise, A Alexeyenko, D Iber, J Ericson
    Science Advances, 2020-09-16;6(38):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  26. 4-Phenylbutyrate ameliorates apoptotic neural cell death in Down syndrome by reducing protein aggregates
    Authors: K Hirata, T Nambara, K Kawatani, N Nawa, H Yoshimatsu, H Kusakabe, K Banno, K Nishimura, M Ohtaka, M Nakanishi, H Taniguchi, H Arahori, K Wada, K Ozono, Y Kitabatake
    Sci Rep, 2020-08-20;10(1):14047.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  27. IPSC-Derived Neuronal Cultures Carrying the Alzheimer's Disease Associated TREM2 R47H Variant Enables the Construction of an A&beta-Induced Gene Regulatory Network
    Authors: S Martins, A Müller-Sch, L Erichsen, M Bohndorf, W Wruck, K Sleegers, C Van Broeck, C Korth, J Adjaye
    Int J Mol Sci, 2020-06-25;21(12):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  28. Generation of human induced pluripotent stem cell line LUMCi027-A and its isogenic gene-corrected line from a patient affected by arrhythmogenic cardiomyopathy and carrying the c.2013delC PKP2 mutation
    Authors: V Meraviglia, CH Arendzen, M Tok, C Freund, AS Maione, E Sommariva, M Bellin
    Stem Cell Res, 2020-05-05;46(0):101835.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  29. Generation of two human induced pluripotent stem cell lines, LUMCi020-A and LUMCi021-A, from two patients with Catecholaminergic Polymorphic Ventricular Tachycardia carrying heterozygous mutations in the RYR2 gene
    Authors: V Meraviglia, CH Arendzen, C Freund, DE Atsma, CL Mummery, M Bellin
    Stem Cell Res, 2020-04-08;45(0):101764.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  30. Wnt Inhibition Facilitates RNA-Mediated Reprogramming of Human Somatic Cells to Naive Pluripotency
    Authors: N Bredenkamp, J Yang, J Clarke, GG Stirparo, F von Meyenn, S Dietmann, D Baker, R Drummond, Y Ren, D Li, C Wu, M Rostovskay, S Eminli-Mei, A Smith, G Guo
    Stem Cell Reports, 2019-11-07;13(6):1083-1098.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  31. Generation of complex human organoid models including vascular networks by incorporation of mesodermal progenitor cells
    Authors: P Wörsdörfer, N Dalda, A Kern, S Krüger, N Wagner, CK Kwok, E Henke, S Ergün
    Sci Rep, 2019-10-30;9(1):15663.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  32. The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis
    Authors: B Di Stefano, EC Luo, C Haggerty, S Aigner, J Charlton, J Brumbaugh, F Ji, I Rabano Jim, KJ Clowers, AJ Huebner, K Clement, I Lipchina, MAC de Kort, A Anselmo, J Pulice, MFM Gerli, H Gu, SP Gygi, RI Sadreyev, A Meissner, GW Yeo, K Hochedling
    Cell Stem Cell, 2019-10-03;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  33. Establishment of PITX3-mCherry knock-in reporter human embryonic stem cell line (WAe009-A-23)
    Authors: S Park, JE Yoo, DR Lee, J Jang, MS Cho, DS Kim, DW Kim
    Stem Cell Res, 2019-07-18;39(0):101499.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  34. Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis
    Authors: M Huang, J Tailor, Q Zhen, AH Gillmor, ML Miller, H Weishaupt, J Chen, T Zheng, EK Nash, LK McHenry, Z An, F Ye, Y Takashima, J Clarke, H Ayetey, FMG Cavalli, B Luu, BS Moriarity, S Ilkhanizad, L Chavez, C Yu, KM Kurian, T Magnaldo, N Sevenet, P Koch, SM Pollard, P Dirks, MP Snyder, DA Largaespad, YJ Cho, JJ Phillips, FJ Swartling, AS Morrissy, M Kool, SM Pfister, MD Taylor, A Smith, WA Weiss
    Cell Stem Cell, 2019-06-13;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  35. Direct Reprogramming of Human Neurons Identifies MARCKSL1 as a Pathogenic Mediator of Valproic Acid-Induced Teratogenicity
    Authors: S Chanda, CE Ang, QY Lee, M Ghebrial, D Haag, Y Shibuya, M Wernig, TC Südhof
    Cell Stem Cell, 2019-05-30;25(1):103-119.e6.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  36. A transient DMSO treatment increases the differentiation potential of human pluripotent stem cells through the Rb family
    Authors: J Li, C Narayanan, J Bian, D Sambo, T Brickler, W Zhang, S Chetty
    PLoS ONE, 2018-12-12;13(12):e0208110.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  37. Improving Cell Survival in Injected Embryos Allows Primed Pluripotent Stem Cells to Generate Chimeric Cynomolgus Monkeys
    Authors: Y Kang, Z Ai, K Duan, C Si, Y Wang, Y Zheng, J He, Y Yin, S Zhao, B Niu, X Zhu, L Liu, L Xiang, L Zhang, Y Niu, W Ji, T Li
    Cell Rep, 2018-11-27;25(9):2563-2576.e9.
    Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
    Sample Types: Whole Cells
    Applications: ICC
  38. Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells
    Authors: AM Lager, OG Corradin, JM Cregg, MS Elitt, HE Shick, BLL Clayton, KC Allan, HE Olsen, M Madhavan, PJ Tesar
    Nat Commun, 2018-09-13;9(1):3708.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  39. Combinatorial Smad2/3 Activities Downstream of Nodal Signaling Maintain Embryonic/Extra-Embryonic Cell Identities during Lineage Priming
    Authors: AD Senft, I Costello, HW King, AW Mould, EK Bikoff, EJ Robertson
    Cell Rep, 2018-08-21;24(8):1977-1985.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  40. Chronic Electrical Stimulation Promotes the Excitability and Plasticity of ESC-derived Neurons following Glutamate-induced Inhibition In vitro
    Authors: CV Latchouman, L Jackson, MSE Sendi, KF Tehrani, LJ Mortensen, SL Stice, M Ghovanloo, L Karumbaiah
    Sci Rep, 2018-07-19;8(1):10957.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  41. TFAP2C regulates transcription in human naive pluripotency by opening enhancers
    Authors: WA Pastor, W Liu, D Chen, J Ho, R Kim, TJ Hunt, A Lukianchik, X Liu, JM Polo, SE Jacobsen, AT Clark
    Nat. Cell Biol., 2018-04-25;20(5):553-564.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  42. Wnt signal activation induces midbrain specification through direct binding of the beta-catenin/TCF4 complex to the EN1 promoter in human pluripotent stem cells
    Authors: JY Kim, JS Lee, HS Hwang, DR Lee, CY Park, SJ Jung, YR You, DS Kim, DW Kim
    Exp. Mol. Med., 2018-04-13;50(4):24.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  43. Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation
    Authors: NS Corsini, AM Peer, P Moeseneder, M Roiuk, TR Burkard, HC Theussl, I Moll, JA Knoblich
    Cell Stem Cell, 2018-04-05;22(4):543-558.e12.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  44. Highly efficient methods to obtain homogeneous dorsal neural progenitor cells from human and mouse embryonic stem cells and induced pluripotent stem cells
    Authors: M Zhang, J Ngo, F Pirozzi, YP Sun, A Wynshaw-Bo
    Stem Cell Res Ther, 2018-03-15;9(1):67.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  45. Generation of iPSCs carrying a common LRRK2 risk allele for in vitro modeling of idiopathic Parkinson's disease
    Authors: L Marrone, C Bus, D Schöndorf, JC Fitzgerald, M Kübler, B Schmid, P Reinhardt, L Reinhardt, M Deleidi, T Levin, A Meixner, B Klink, M Glatza, CJ Gloeckner, T Gasser, J Sternecker
    PLoS ONE, 2018-03-07;13(3):e0192497.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  46. Defined Culture Conditions Accelerate Small-molecule-assisted Neural Induction for the Production of Neural Progenitors from Human-induced Pluripotent Stem Cells
    Authors: P Walsh, V Truong, C Hill, ND Stoflet, J Baden, WC Low, SA Keirstead, JR Dutton, AM Parr
    Cell Transplant, 2017-12-01;26(12):1890-1902.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  47. Transcriptome analysis reveals determinant stages controlling human embryonic stem cell commitment to neuronal cells
    Authors: Y Li, R Wang, N Qiao, G Peng, K Zhang, K Tang, JJ Han, N Jing
    J. Biol. Chem., 2017-09-26;292(48):19590-19604.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  48. A hypomorphic PIGA gene mutation causes severe defects in neuron development and susceptibility to complement-mediated toxicity in a human iPSC model
    Authors: X Yuan, Z Li, AC Baines, E Gavriilaki, Z Ye, Z Wen, EM Braunstein, LG Biesecker, L Cheng, X Dong, RA Brodsky
    PLoS ONE, 2017-04-25;12(4):e0174074.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  49. Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes
    Authors: ZS Nevin, DC Factor, RT Karl, P Douvaras, J Laukka, MS Windrem, SA Goldman, V Fossati, GM Hobson, PJ Tesar
    Am. J. Hum. Genet., 2017-03-30;100(4):617-634.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  50. Differentiation of oligodendrocyte progenitor cells from dissociated monolayer and feeder-free cultured pluripotent stem cells
    Authors: T Yamashita, Y Miyamoto, Y Bando, T Ono, S Kobayashi, A Doi, T Araki, Y Kato, T Shirakawa, Y Suzuki, J Yamauchi, S Yoshida, N Sato
    PLoS ONE, 2017-02-13;12(2):e0171947.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  51. Dynamic behaviour of human neuroepithelial cells in the developing forebrain
    Authors: L Subramania, M Bershteyn, MF Paredes, AR Kriegstein
    Nat Commun, 2017-01-31;8(0):14167.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  52. Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia
    Authors: M Bershteyn, TJ Nowakowski, AA Pollen, E Di Lullo, A Nene, A Wynshaw-Bo, AR Kriegstein
    Cell Stem Cell, 2017-01-19;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  53. Cytosine-5 RNA Methylation Regulates Neural Stem Cell Differentiation and�Motility
    Stem Cell Reports, 2016-12-29;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  54. Direct induction of neural progenitor cells transiently passes through a partially reprogrammed state
    Authors: Rui Gao
    Biomaterials, 2016-12-10;119(0):53-67.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: IHC
  55. Induced Pluripotent Stem Cells for Disease Modeling and Evaluation of Therapeutics for Niemann-Pick Disease Type A
    Stem Cells Transl Med, 2016-08-02;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: IHC-Fr
  56. Design of a Vitronectin-Based Recombinant Protein as a Defined Substrate for Differentiation of Human Pluripotent Stem Cells into Hepatocyte-Like Cells.
    Authors: Nagaoka M, Kobayashi M, Kawai C, Mallanna S, Duncan S
    PLoS ONE, 2015-08-26;10(8):e0136350.
    Species: Human
    Sample Types: Whole Cells
    Applications: IHC
  57. Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells.
    Authors: Paull D, Sevilla A, Zhou H, Hahn A, Kim H, Napolitano C, Tsankov A, Shang L, Krumholz K, Jagadeesan P, Woodard C, Sun B, Vilboux T, Zimmer M, Forero E, Moroziewicz D, Martinez H, Malicdan M, Weiss K, Vensand L, Dusenberry C, Polus H, Sy K, Kahler D, Gahl W, Solomon S, Chang S, Meissner A, Eggan K, Noggle S
    Nat Methods, 2015-08-03;12(9):885-92.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: IHC
  58. Derivation and long-term culture of transgene-free human induced pluripotent stem cells on synthetic substrates.
    Authors: Villa-Diaz L, Kim J, Lahann J, Krebsbach P
    Stem Cells Transl Med, 2014-10-13;3(12):1410-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  59. iPSC-Derived neural stem cells act via kinase inhibition to exert neuroprotective effects in spinal muscular atrophy with respiratory distress type 1.
    Authors: Simone C, Nizzardo M, Rizzo F, Ruggieri M, Riboldi G, Salani S, Bucchia M, Bresolin N, Comi G, Corti S
    Stem Cell Reports, 2014-07-04;3(2):297-311.
    Species: Human
    Sample Types: Whole Cells
    Applications: IHC
  60. Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression.
    Authors: Ferrarese R, Harsh G, Yadav A, Bug E, Maticzka D, Reichardt W, Dombrowski S, Miller T, Masilamani A, Dai F, Kim H, Hadler M, Scholtens D, Yu I, Beck J, Srinivasasainagendra V, Costa F, Baxan N, Pfeifer D, von Elverfeldt D, Backofen R, Weyerbrock A, Duarte C, He X, Prinz M, Chandler J, Vogel H, Chakravarti A, Rich J, Carro M, Bredel M
    J Clin Invest, 2014-05-27;124(7):2861-76.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  61. Translating dosage compensation to trisomy 21.
    Authors: Jiang J, Jing Y, Cost G, Chiang J, Kolpa H, Cotton A, Carone D, Carone B, Shivak D, Guschin D, Pearl J, Rebar E, Byron M, Gregory P, Brown C, Urnov F, Hall L, Lawrence J
    Nature, 2013-07-17;500(7462):296-300.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  62. Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells.
    Authors: Najm, Fadi J, Lager, Angela M, Zaremba, Anita, Wyatt, Krysta, Caprariello, Andrew V, Factor, Daniel C, Karl, Robert T, Maeda, Tadao, Miller, Robert H, Tesar, Paul J
    Nat Biotechnol, 2013-04-14;31(5):426-33.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  63. Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling.
    Authors: Reinhardt P, Glatza M, Hemmer K, Tsytsyura Y, Thiel C, Hoing S, Moritz S, Parga J, Wagner L, Bruder J, Wu G, Schmid B, Ropke A, Klingauf J, Schwamborn J, Gasser T, Scholer H, Sterneckert J
    PLoS ONE, 2013-03-22;8(3):e59252.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  64. Sonic hedgehog signaling controls thalamic progenitor identity and nuclei specification in mice.
    Authors: Vue TY, Bluske K, Alishahi A, Yang LL, Koyano-Nakagawa N, Novitch B, Nakagawa Y
    J. Neurosci., 2009-04-08;29(14):4484-97.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC

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Human/Mouse/Rat SOX1 Antibody
By Ying Chen on 08/19/2019
Application: ICC/IF Sample Tested: neural stem cells derived from h9 Species: Human

Neural stem cells derived from H9 cells were fixed in 4% PFA for 15 minutes. The cells were incubated in the sox1 antibody at the concentration of 5ug/ml overnight at 4 degree, the followed with secondary antibody incubation at room temperature for 1hour.

Immunocytochemistry/Immunofluorescence Human/Mouse/Rat SOX1 Antibody AF3369
Human/Mouse/Rat SOX1 Antibody
By Anonymous on 03/21/2018
Application: ICC/IF Sample Tested: hESC-derived NSC Species: Human

SOX1 was detected human embryonic stem cells-derived neural stem cells using Goat Anti-Human/Mouse/Rat SOX1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3369) at 1 µg/mL for overnight at 4°C. Cells were stained using the Donkey anti-Goat IgG (H+L) Cross-Adsorbed, Alexa Fluor® 568 and counterstained with DAPI (blue).

Immunocytochemistry/Immunofluorescence Human/Mouse/Rat SOX1 Antibody AF3369
Human SOX1 Antibody
By Anonymous on 10/26/2015
Application: ICC/IF Sample Tested: human NSC Species: Human

Specificity: Specific
Sensitivity: Sensitive
Buffer: 1% BSA + 0.3% Triton X-100 in PBS
Dilution: 1/100

Immunocytochemistry/Immunofluorescence Human SOX1 Antibody AF3369
Human SOX1 Antibody
By Anonymous on 10/26/2015
Application: ICC/IF Sample Tested: human fibroblast and human neural stem cells Species: Human

Specificity: Specific
Sensitivity: Sensitive
Buffer: 1% BSA + 0.3% Triton X-100 in PBS
Dilution: 1/100

Immunocytochemistry/Immunofluorescence Human SOX1 Antibody AF3369