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Human NKG2A/CD159a PE-conjugated Antibody

Catalog #: FAB1059P
31 Citations 1 Review Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
FAB1059P-025
FAB1059P-100
Detection of NKG2A/CD159a in Human PBMCs by Flow Cytometry.
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Citations (31)
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Reviews (1)
Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human NKG2A/CD159a PE-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Recognizes the human NKG2A/CD94 heterodimer. It does not recognize the NKG2C/CD94 heterodimer or the CD94 homodimer.
Source
Monoclonal Mouse IgG2A Clone # 131411
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
BaF3 mouse pro-B cell line transfected with human NKG2A and CD94
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Phycoerythrin (Excitation= 488 nm, Emission= 565-605 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of NKG2A/CD159a antibody in Human PBMCs antibody by Flow Cytometry. View Larger

Detection of NKG2A/CD159a in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human NCAM-1/CD56 APC-conjugated Monoclonal Antibody (Catalog # FAB2408A) and either (A) Mouse Anti-Human NKG2A/CD159a PE-conjugated Monoclonal Antibody (Catalog # FAB1059P) or (B) Mouse IgG2APhycoerythrin Isotype Control (Catalog # IC003P). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: NKG2A/CD159a

NKG2A, also known as CD159a, is a type II transmembrane receptor having a single extracellular lectin-like domain and a cytoplasmic ITIM motif. It associates with CD94 and is expressed on NK cells and some activated T cell populations. The NKG2A/CD94 complex delivers an inhibitory signal upon recognition of its ligand, HLA-E.

Long Name
Natural Killer G2A
Entrez Gene IDs
3821 (Human); 16641 (Mouse); 102121106 (Cynomolgus Monkey)
Alternate Names
CD159 antigen-like family member A; CD159a antigen; CD159a; C-lectin type II protein; killer cell lectin-like receptor subfamily C, member 1; Klrc1; MGC13374; natural killer cell lectin; natural killer group protein 2; NK cell receptor A; NKG2; NKG2-1/B activating NK receptor; NKG2A; NKG2-A; NKG2-A/B type II integral membrane protein; NKG2-A/B-activating NK receptor; NKG2-A/NKG2-B type II integral membrane protein; NKG2AMGC59791; NKG2-B

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Citations for Human NKG2A/CD159a PE-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

31 Citations: Showing 1 - 10
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  1. Defining TCRgammadelta lymphoproliferative disorders by combined immunophenotypic and molecular evaluation
    Authors: A Teramo, A Binatti, E Ciabatti, G Schiavoni, G Tarrini, G Barilà, G Calabretto, C Vicenzetto, VR Gasparini, M Facco, I Petrini, R Grossi, N Pisanti, S Bortoluzzi, B Falini, E Tiacci, S Galimberti, G Semenzato, R Zambello
    Nature Communications, 2022-06-08;13(1):3298.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  2. 3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T�cells
    Authors: Z Wang, HP McWilliams, H Reza, JR Ostberg, W Chen, X Wang, C Huynh, V Vyas, WC Chang, R Starr, JR Wagner, B Aguilar, X Yang, X Wu, J Wang, W Chen, E Koelker-Wo, CS Seet, A Montel-Hag, GM Crooks, SJ Forman, CE Brown
    Cell Stem Cell, 2022-03-11;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  3. Telomerase Reverse Transcriptase Increases Proliferation and Lifespan of Human NK Cells without Immortalization
    Authors: MA Streltsova, MO Ustiuzhani, EV Barsov, SA Kust, RA Velichinsk, EI Kovalenko
    Biomedicines, 2021-06-09;9(6):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  4. CD6 is a target for cancer immunotherapy
    Authors: JH Ruth, M Gurrea-Rub, KS Athukorala, SM Rasmussen, D Weber, PM Randon, RJ Gedert, ME Lind, MA Amin, PL Campbell, PS Tsou, Y Mao-Draaye, Q Wu, TM Lanigan, VG Keshamouni, NG Singer, F Lin, DA Fox
    JCI Insight, 2021-03-08;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  5. TIM-3 Expression Is Downregulated on Human NK Cells in Response to Cancer Targets in Synergy with Activation
    Authors: TN Dao, S Utturkar, N Atallah La, S Matosevic
    Cancers (Basel), 2020-08-26;12(9):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  6. Microwave ablation of primary breast cancer inhibits metastatic progression in model mice via activation of natural killer cells
    Authors: M Yu, H Pan, N Che, L Li, C Wang, Y Wang, G Ma, M Qian, J Liu, M Zheng, H Xie, L Ling, Y Zhao, X Guan, Q Ding, W Zhou, S Wang
    Cell. Mol. Immunol., 2020-05-08;0(0):.
    Species: Human
    Sample Types: PBMC
    Applications: Flow Cytometry
  7. Phenotypic and Functional Changes in Peripheral Blood Natural Killer Cells in Crohn Disease Patients.
    Authors: Samarani S, Sagala P, Jantchou P, Grimard G, Faure C, Deslandres C, Amre D, Ahmad A
    Mediators Inflamm, 2020-02-19;2020(0):6401969.
    Species: Human
    Sample Types: Whole Cells
    Applications: FLOW, Flow Cytometry
  8. Possible role of highly activated mucosal NK cells against viral respiratory infections in children undergoing haematopoietic stem cell transplantation
    Authors: M Vela, T Del Rosal, A Pérez-Mart, J Valentín, I Casas, F Pozo, F Reinoso-Ba, D Bueno, D Corral, A Méndez-Ech, Y Mozo, C Calvo
    Sci Rep, 2019-12-11;9(1):18792.
    Species: Human
    Sample Types: Nasal Fluid
  9. Cryopreserved Human Natural Killer Cells Exhibit Potent Antitumor Efficacy against Orthotopic Pancreatic Cancer through Efficient Tumor-Homing and Cytolytic Ability (Running Title: Cryopreserved NK Cells Exhibit Antitumor Effect)
    Authors: E Oh, B Min, Y Li, C Lian, J Hong, GM Park, B Yang, SY Cho, YK Hwang, CO Yun
    Cancers (Basel), 2019-07-09;11(7):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  10. Analysis of NK cell clones obtained using interleukin-2 and gene-modified K562 cells revealed the ability of "senescent" NK cells to lose CD57 expression and start expressing NKG2A
    Authors: MA Streltsova, SA Erokhina, LM Kanevskiy, DA Lee, WG Telford, AM Sapozhniko, EI Kovalenko
    PLoS ONE, 2018-12-05;13(12):e0208469.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  11. Altered NKp30, NKp46, NKG2D, and DNAM-1 Expression on Circulating NK Cells Is Associated with Tumor Progression in Human Gastric Cancer
    Authors: B Han, FY Mao, YL Zhao, YP Lv, YS Teng, M Duan, W Chen, P Cheng, TT Wang, ZY Liang, JY Zhang, YG Liu, G Guo, QM Zou, Y Zhuang, LS Peng
    J Immunol Res, 2018-09-03;2018(0):6248590.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  12. Varicella zoster virus productively infects human natural killer cells and manipulates phenotype
    Authors: TM Campbell, BP McSharry, M Steain, TM Ashhurst, B Slobedman, A Abendroth
    PLoS Pathog., 2018-04-30;14(4):e1006999.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  13. Human M2 Macrophages Limit NK Cell Effector Functions through Secretion of TGF-? and Engagement of CD85j
    Authors: SY Nuñez, A Ziblat, F Secchiari, NI Torres, JM Sierra, XL Raffo Irao, RE Araya, CI Domaica, MB Fuertes, NW Zwirner
    J. Immunol., 2017-12-27;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  14. Activated hepatic stellate cells impair NK cell anti-fibrosis capacity through a TGF-?-dependent emperipolesis in HBV cirrhotic patients
    Authors: J Shi, J Zhao, X Zhang, Y Cheng, J Hu, Y Li, X Zhao, Q Shang, Y Sun, B Tu, L Shi, B Gao, FS Wang, Z Zhang
    Sci Rep, 2017-03-14;7(0):44544.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  15. Eomesodermin and T-bet mark developmentally distinct human natural killer cells
    Authors: A Collins, N Rothman, K Liu, SL Reiner
    JCI Insight, 2017-03-09;2(5):e90063.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  16. IL-21-Induced MHC Class II+ NK Cells Promote the Expansion of Human Uncommitted CD4+ Central Memory T Cells in a Macrophage Migration Inhibitory Factor-Dependent Manner
    Authors: Romain Loyon
    J Immunol, 2016-05-27;197(1):85-96.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  17. CD3(bright)CD56(+) T cells associate with pegylated interferon-alpha treatment nonresponse in chronic hepatitis B patients
    Sci Rep, 2016-05-13;6(0):25567.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  18. Alteration of Natural Killer cell phenotype and function in obese individuals.
    Authors: Viel S, Besson L, Charrier E, Marcais A, Disse E, Bienvenu J, Walzer T, Dumontet C
    Clin Immunol, 2016-01-18;177(0):12-17.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  19. Up-regulation of activating and inhibitory NKG2 receptors in allogeneic and autologous hematopoietic stem cell grafts.
    Authors: Picardi A, Mengarelli A, Marino M, Gallo E, Benevolo M, Pescarmona E, Cocco R, Fraioli R, Tremante E, Petti M, De Fabritiis P, Giacomini P
    J Exp Clin Cancer Res, 2015-09-11;34(0):98.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  20. NKP30-B7-H6 Interaction Aggravates Hepatocyte Damage through Up-Regulation of Interleukin-32 Expression in Hepatitis B Virus-Related Acute-On-Chronic Liver Failure.
    Authors: Zou Y, Bao J, Pan X, Lu Y, Liao S, Wang X, Wang G, Lin D
    PLoS ONE, 2015-08-04;10(8):e0134568.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  21. Regulatory Dendritic Cells Restrain NK Cell IFN-gamma Production through Mechanisms Involving NKp46, IL-10, and MHC Class I-Specific Inhibitory Receptors.
    Authors: Spallanzani R, Torres N, Avila D, Ziblat A, Iraolagoitia X, Rossi L, Domaica C, Fuertes M, Rabinovich G, Zwirner N
    J Immunol, 2015-07-31;195(5):2141-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  22. Human Induced Pluripotent Stem Cells Are Targets for Allogeneic and Autologous Natural Killer (NK) Cells and Killing Is Partly Mediated by the Activating NK Receptor DNAM-1.
    Authors: Kruse V, Hamann C, Monecke S, Cyganek L, Elsner L, Hubscher D, Walter L, Streckfuss-Bomeke K, Guan K, Dressel R
    PLoS ONE, 2015-05-07;10(5):e0125544.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  23. Overexpression of CD85j in TNBC patients inhibits Cetuximab-mediated NK-cell ADCC but can be restored with CD85j functional blockade.
    Authors: Roberti M, Julia E, Rocca Y, Amat M, Bravo A, Loza J, Colo F, Loza C, Fabiano V, Maino M, Podhorzer A, Fainboim L, Barrio M, Mordoh J, Levy E
    Eur J Immunol, 2015-04-07;45(5):1560-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  24. Long-term effect on natural killer cells by interferon-alpha therapy on the outcomes of HCV infection.
    Authors: Hu X, Jiang Y, Li X, Gao Y, Guo X, Chi X, Yan H, Feng J, Zhong J, Sun B, Shao X, Xiao W, Pan Y, Niu J
    J Interferon Cytokine Res, 2013-12-24;34(5):366-75.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  25. Intracellular poly(I:C) initiated gastric adenocarcinoma cell apoptosis and subsequently ameliorated NK cell functions.
    Authors: Qu, Jing, Hou, Zhaohua, Han, Qiuju, Jiang, Wen, Zhang, Cai, Tian, Zhigang, Zhang, Jian
    J Interferon Cytokine Res, 2013-09-13;34(1):52-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  26. Natural killer cells are characterized by the concomitantly increased interferon-gamma and cytotoxicity in acute resolved hepatitis B patients.
    Authors: Zhao J, Li Y, Jin L, Zhang S, Fan R, Sun Y, Zhou C, Shang Q, Li W, Zhang Z, Wang F
    PLoS ONE, 2012-11-01;7(11):e49135.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  27. Phenotype markers and cytokine intracellular production by CD8+ gammadelta T lymphocytes do not support a regulatory T profile in Behcet's disease patients and healthy controls.
    Authors: Clemente A, Cambra A, Munoz-Saa I, Crespi C, Pallares L, Juan A, Matamoros N, Julia MR
    Immunol. Lett., 2010-02-16;129(2):57-63.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  28. A novel immunomodulatory mechanism of ribavirin in suppressing natural killer cell function.
    Authors: Ogbomo H, Michaelis M, Altenbrandt B, Doerr HW, Cinatl J
    Biochem. Pharmacol., 2009-08-07;79(2):188-97.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  29. Binding of excreted and/or secreted products of adult hookworms to human NK cells in Necator americanus-infected individuals from Brazil.
    Authors: Teixeira-Carvalho A, Fujiwara RT, Stemmy EJ, Olive D, Damsker JM, Loukas A, Correa-Oliveira R, Constant SL, Bethony JM
    Infect. Immun., 2008-10-06;76(12):5810-6.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  30. Functional impairment in circulating and intrahepatic NK cells and relative mechanism in hepatocellular carcinoma patients.
    Authors: Cai L, Zhang Z, Zhou L, Wang H, Fu J, Zhang S, Shi M, Zhang H, Yang Y, Wu H, Tien P, Wang FS
    Clin. Immunol., 2008-09-27;129(3):428-37.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  31. Isolation and characterization of CD8+ regulatory T cells in multiple sclerosis.
    Authors: Correale J, Villa A
    J. Neuroimmunol., 2008-01-30;195(1):121-34.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry

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Human NKG2A/CD159a PE-conjugated Antibody
By Anonymous on 01/24/2021
Application: Flow Sample Tested: Peripheral blood mononuclear cells (PBMCs) Species: Human
Flow Cytometry Human NKG2A/CD159a PE-conjugated Antibody FAB1059P