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Human Prox1 Antibody

Catalog #: AF2727
89 Citations 1 Review Datasheet / COA / SDS
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AF2727
AF2727-SP
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Detection of Human Prox1 by Western Blot.
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Citations (89)
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Reviews (1)
Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human Prox1 Antibody Summary

Species Reactivity
Human
Specificity
Detects human Prox1 in direct ELISAs and Western blots.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
E. coli-derived recombinant human Prox1
Pro2-Gln259
Accession # Q92786
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
See below
Simple Western
10 µg/mL
See below
Immunocytochemistry
5-15 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Human Prox1 antibody by Western Blot. View Larger

Detection of Human Prox1 by Western Blot. Western blot shows lysates of HepG2 human hepatocellular carcinoma cell line. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human Prox1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2727) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for Prox1 at approximately 83 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Immunocytochemistry Prox1 antibody in HepG2 Human Hepatocellular Carcinoma Cell Line by Immunocytochemistry (ICC). View Larger

Prox1 in HepG2 Human Hepatocellular Carcinoma Cell Line. Prox1 was detected in immersion fixed HepG2 human hepatocellular carcinoma cell line using Goat Anti-Human Prox1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2727) at 15 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (left panel, red; Catalog # NL001) and counterstained with DAPI (right panel, blue). Specific staining was localized to nuclei. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Simple Western Detection of Human Prox1 antibody by Simple Western<SUP>TM</SUP>. View Larger

Detection of Human Prox1 by Simple WesternTM. Simple Western lane view shows lysates of HepG2 human hepatocellular carcinoma cell line, loaded at 0.2 mg/mL. A specific band was detected for Prox1 at approximately 114 kDa (as indicated) using 10 µg/mL of Goat Anti-Human Prox1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2727) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Prox1

Prox1, the homologue of Drosophila Prospero, is a homeobox-containing transcription factor that binds and functions as a co-receptor of liver receptor homolog 1 (LRH1/NR5A2). It is a specific marker for lymphatic endothelial cells as well as hepatoblasts and hepatocytes. Human Prox1 shares 97% amino acid sequence homology with mouse and rat Prox1.

Long Name
Prospero-related Homeobox 1
Entrez Gene IDs
5629 (Human)
Alternate Names
Homeobox prospero-like protein PROX1; prospero homeobox 1; prospero homeobox protein 1; prospero-related homeobox 1; Prox1; PROX-1

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Citations for Human Prox1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

89 Citations: Showing 1 - 10
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  1. Calcitonin gene-related peptide and intermedin induce phosphorylation of p44/42 MAPK in primary human lymphatic endothelial cells in vitro
    Authors: Hasan, SR;Manolis, D;Stephenson, E;Ryskiewicz-Sokalska, OA;Maraveyas, A;Nikitenko, LL;
    Cellular signalling
    Species: Human
    Sample Types: Whole Cells
    Applications: Immunocytochemistry
  2. Quantitative proteomics reveals CLR interactome in primary human cells
    Authors: Manolis, D;Hasan, S;Maraveyas, A;O'Brien, DP;Kessler, BM;Kramer, H;Nikitenko, LL;
    The Journal of biological chemistry
    Species: Human
    Sample Types: Whole Cells
    Applications: Immunocytochemistry
  3. Spatial enhancer activation influences inhibitory neuron identity during mouse embryonic development
    Authors: Dvoretskova, E;Ho, MC;Kittke, V;Neuhaus, F;Vitali, I;Lam, DD;Delgado, I;Feng, C;Torres, M;Winkelmann, J;Mayer, C;
    Nature neuroscience
    Species: Viral
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  4. Influenza Induces Lung Lymphangiogenesis Independent of YAP/TAZ Activity in Lymphatic Endothelial Cells
    Authors: Crossey, E;Carty, S;Shao, F;Henao-Vasquez, J;Ysasi, AB;Zeng, M;Hinds, A;Lo, M;Tilston-Lunel, A;Varelas, X;Jones, MR;Fine, A;
    Research square
    Species: Murine polyomavirus strain A3
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  5. PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway
    Authors: Ohata, H;Shiokawa, D;Sakai, H;Kanda, Y;Okimoto, Y;Kaneko, S;Hamamoto, R;Nakagama, H;Okamoto, K;
    Cell reports
    Species: Xenograft, Human
    Sample Types: Organoid, Whole Tissue
    Applications: IHC
  6. Gata3 is Required in Late Proneurosensory Development for Proper Sensory Cell Formation and Organization
    Authors: PV Blinkiewic, MR Long, ZA Stoner, EM Ketchum, SN Sheltz-Kem, JS Duncan
    Research square, 2023-04-14;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  7. A Prox1 enhancer represses haematopoiesis in the lymphatic vasculature
    Authors: J Kazenwadel, P Venugopal, A Oszmiana, J Toubia, L Arriola-Ma, V Panara, SG Piltz, C Brown, W Ma, AW Schreiber, K Koltowska, S Taoudi, PQ Thomas, HS Scott, NL Harvey
    Nature, 2023-01-25;614(7947):343-348.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  8. Bleb-related Porcine Lymphatic Outflow Is Greater from Subconjunctival compared to Subtenon Blebs
    Authors: Jong Yeon Lee, Clemens Adolf Strohmaier, Goichi Akiyama, Sindhu Saraswathy, Chungkwon Yoo, Yong Yeon Kim et al.
    Journal of Current Glaucoma Practice
    Species: Porcine
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  9. Single-cell transcriptomics reveal cellular diversity of aortic valve and the immunomodulation by PPARgamma during hyperlipidemia
    Authors: SH Lee, N Kim, M Kim, SH Woo, I Han, J Park, K Kim, KS Park, K Kim, D Shim, SE Park, JY Zhang, DM Go, DY Kim, WK Yoon, SP Lee, J Chung, KW Kim, JH Park, SH Lee, S Lee, SJ Ann, SH Lee, HS Ahn, SC Jeong, TK Kim, GT Oh, WY Park, HO Lee, JH Choi
    Nature Communications, 2022-09-17;13(1):5461.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  10. SHH and Notch regulate SOX9+ progenitors to govern arcuate POMC neurogenesis
    Authors: E Place, E Manning, DW Kim, A Kinjo, G Nakamura, K Ohyama
    Frontiers in Neuroscience, 2022-08-11;16(0):855288.
    Species: Chicken
    Sample Types: Whole Cells
    Applications: ICC/IF
  11. Serotonergic regulation of bipolar cell survival in the developing cerebral cortex
    Authors: FK Wong, M Selten, C Rosés-Nove, V Sreenivasa, N Pallas-Baz, E Serafeimid, A Hanusz-God, F Oozeer, R Edwards, O Marín
    Cell Reports, 2022-07-05;40(1):111037.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  12. RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer
    Authors: AE Hall, SÖ Pohl, P Cammareri, S Aitken, NT Younger, M Raponi, CV Billard, AB Carrancio, A Bastem, P Freile, F Haward, IR Adams, JF Caceres, P Preyzner, A von Kriegs, MG Dunlop, FV Din, KB Myant
    Nature Communications, 2022-05-19;13(1):2791.
    Species: Mouse
    Sample Types: Cell Lysates, Whole Tissue
    Applications: IHC, Western Blot
  13. Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities
    Authors: A Choudhury, ST Magill, CD Eaton, BC Prager, WC Chen, MA Cady, K Seo, CG Lucas, TJ Casey-Clyd, HN Vasudevan, SJ Liu, JE Villanueva, TC Lam, JK Pu, LF Li, GK Leung, DL Swaney, MY Zhang, JW Chan, Z Qiu, MV Martin, MS Susko, SE Braunstein, NAO Bush, JD Schulte, N Butowski, PK Sneed, MS Berger, NJ Krogan, A Perry, JJ Phillips, DA Solomon, JF Costello, MW McDermott, JN Rich, DR Raleigh
    Nature Genetics, 2022-05-09;54(5):649-659.
    Species: Human, Xenograft
    Sample Types: Whole Tissue
    Applications: IHC
  14. Dynamic interplay between thalamic activity and Cajal-Retzius cells regulates the wiring of cortical layer 1
    Authors: I Genescu, M Aníbal-Mar, V Kouskoff, N Chenouard, C Mailhes-Ha, H Cartonnet, L Lokmane, FM Rijli, G López-Bend, F Gambino, S Garel
    Cell Reports, 2022-04-12;39(2):110667.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  15. Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T�cell de-adhesion and passive transport by flow in inflamed afferent lymphatics
    Authors: MC Friess, I Kritikos, P Schineis, JD Medina-San, AO Gkountidi, A Vallone, EC Sigmund, C Schwitter, M Vranova, C Matti, J Arasa, C Saygili De, E Bovay, ST Proulx, M Tomura, A Rot, DF Legler, TV Petrova, C Halin
    Cell Reports, 2022-02-01;38(5):110334.
    Species: Mouse
    Sample Types: Whole Tissues
    Applications: IHC
  16. Live imaging of neolymphangiogenesis identifies acute antimetastatic roles of dsRNA mimics
    Authors: D Olmeda, D Cerezo-Wal, C Mucientes, TG Calvo, E Cañón, D Alonso-Cur, N Ibarz, J Muñoz, JL Rodriguez-, P Ortiz-Rome, S Ortega, MS Soengas
    Embo Molecular Medicine, 2021-11-11;0(0):e12924.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  17. Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies
    Authors: BR Thomson, P Liu, T Onay, J Du, SW Tompson, S Misener, RR Purohit, TL Young, J Jin, SE Quaggin
    Nature Communications, 2021-10-18;12(1):6072.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  18. Vegfr3-tdTomato, a reporter mouse for microscopic visualization of lymphatic vessel by multiple modalities
    Authors: E Redder, N Kirschnick, S Bobe, R Hägerling, NR Hansmeier, F Kiefer
    PLoS ONE, 2021-09-20;16(9):e0249256.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  19. Reactive, Adult Neurogenesis From Increased Neural Progenitor Cell Proliferation Following Alcohol Dependence in Female Rats
    Authors: NN Nawarawong, KR Thompson, SP Guerin, C Anasooya S, H Peng, K Nixon
    Frontiers in Neuroscience, 2021-09-14;15(0):689601.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: IHC
  20. A neurogenic microenvironment defined by excitatory-inhibitory neuronal circuits in adult dentate gyrus
    Authors: M Uemura, S Blankvoort, SSL Tok, L Yuan, LF Cobar, KK Lit, A Tashiro
    Cell Reports, 2021-07-06;36(1):109324.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  21. Mutually exclusive lymphangiogenesis or perineural infiltration in human skin squamous-cell carcinoma
    Authors: J Schaller, HM Hajjami, S Rusakiewic, K Ioannidou, N Piazzon, A Miles, D Golshayan, O Gaide, D Hohl, DE Speiser, K Schaeuble
    Oncotarget, 2021-03-30;12(7):638-648.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  22. PlexinA4-Semaphorin3A-mediated crosstalk between main cortical interneuron classes is required for superficial interneuron lamination
    Authors: G Limoni, S Murthy, D Jabaudon, A Dayer, M Niquille
    Cell Reports, 2021-01-26;34(4):108644.
    Species: Mouse, Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  23. Blood and lymphatic systems are segregated by the FLCN tumor suppressor
    Authors: I Tai-Nagara, Y Hasumi, D Kusumoto, H Hasumi, K Okabe, T Ando, F Matsuzaki, F Itoh, H Saya, C Liu, W Li, YS Mukouyama, W Marston Li, X Liu, M Hirashima, Y Suzuki, S Funasaki, Y Satou, M Furuya, M Baba, Y Kubota
    Nature Communications, 2020-12-09;11(1):6314.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  24. Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus
    Authors: A Rattner, CE Terrillion, C Jou, T Kleven, SF Hu, J Williams, Z Hou, M Aggarwal, S Mori, G Shin, LA Goff, MP Witter, M Pletnikov, AA Fenton, J Nathans
    Elife, 2020-10-21;9(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  25. Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi
    Authors: SP Hong, MJ Yang, H Cho, I Park, H Bae, K Choe, SH Suh, RH Adams, K Alitalo, D Lim, GY Koh
    Nat Commun, 2020-08-14;11(1):4102.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  26. The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic
    Authors: E Kadosh, I Snir-Alkal, A Venkatacha, S May, A Lasry, E Elyada, A Zinger, M Shaham, G Vaalani, M Mernberger, T Stiewe, E Pikarsky, M Oren, Y Ben-Neriah
    Nature, 2020-07-29;0(0):.
    Species: Mouse, Transgenic Mouse
    Sample Types: Cell Fraction, Cell Lysates, Whole Cells, Whole Tissue
    Applications: IHC, Western Blot
  27. S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling
    Authors: X Geng, K Yanagida, RG Akwii, D Choi, L Chen, Y Ho, B Cha, MR Mahamud, K Berman de, H Ichise, H Chen, J Wythe, CM Mikelis, T Hla, RS Srinivasan
    JCI Insight, 2020-07-23;0(0):.
    Species: Human, Transgenic Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC
  28. Atypical cadherin Fat4 orchestrates lymphatic endothelial cell polarity in response to flow
    Authors: KL Betterman, DL Sutton, GA Secker, J Kazenwadel, A Oszmiana, L Lim, N Miura, L Sorokin, BM Hogan, ML Kahn, H McNeill, NL Harvey
    J. Clin. Invest., 2020-06-01;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  29. TGF-beta and TNF-alpha cooperatively induce mesenchymal transition of lymphatic endothelial cells via activation of Activin signals
    Authors: Y Yoshimatsu, S Kimuro, J Pauty, K Takagaki, S Nomiyama, A Inagawa, K Maeda, KA Podyma-Ino, K Kajiya, YT Matsunaga, T Watabe
    PLoS ONE, 2020-05-01;15(5):e0232356.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  30. Hippocampal granule cell dispersion: a non-specific finding in pediatric patients with no history of seizures
    Authors: A Roy, KJ Millen, RP Kapur
    Acta Neuropathol Commun, 2020-04-21;8(1):54.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  31. Meningeal lymphatic vessels regulate brain tumor drainage and immunity
    Authors: X Hu, Q Deng, L Ma, Q Li, Y Chen, Y Liao, F Zhou, C Zhang, L Shao, J Feng, T He, W Ning, Y Kong, Y Huo, A He, B Liu, J Zhang, R Adams, Y He, F Tang, X Bian, J Luo
    Cell Res., 2020-02-24;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  32. A Second Heart Field-Derived Vasculogenic Niche Contributes to Cardiac Lymphatics
    Authors: Lioux G, Liu X, Temi�o S et al.
    Developmental Cell
  33. Transcription Factor Prospero Homeobox 1 (PROX1) as a Potential Angiogenic Regulator of Follicular Thyroid Cancer Dissemination
    Authors: M Rudzi?ska, M Mikula, KD Arczewska, E Gajda, S Sabali?ska, T St?pie?, J Ostrowski, B Czarnocka
    Int J Mol Sci, 2019-11-10;20(22):.
    Species: Human
    Sample Types: Protein Lysates
    Applications: Western Blot
  34. High tissue MMP14 expression predicts worse survival in gastric cancer, particularly with a low PROX1
    Authors: A Kasurinen, S Gramolelli, J Hagström, A Laitinen, A Kokkola, Y Miki, K Lehti, M Yashiro, PM Ojala, C Böckelman, C Haglund
    Cancer Med, 2019-09-27;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  35. An important role of cutaneous lymphatic vessels in coordinating and promoting anagen hair follicle growth
    Authors: SY Yoon, LC Dieterich, S Karaman, ST Proulx, SB Bachmann, C Sciaroni, M Detmar
    PLoS ONE, 2019-07-25;14(7):e0220341.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  36. Panicle-Shaped Sympathetic Architecture in the Spleen Parenchyma Modulates Antibacterial Innate Immunity
    Authors: X Ding, H Wang, X Qian, X Han, L Yang, Y Cao, Q Wang, J Yang
    Cell Rep, 2019-06-25;27(13):3799-3807.e3.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  37. Immature excitatory neurons develop during adolescence in the human amygdala
    Authors: SF Sorrells, MF Paredes, D Velmeshev, V Herranz-Pé, K Sandoval, S Mayer, EF Chang, R Insausti, AR Kriegstein, JL Rubenstein, J Manuel Gar, EJ Huang, A Alvarez-Bu
    Nat Commun, 2019-06-21;10(1):2748.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  38. Transcriptional landscape of pulmonary lymphatic endothelial cells during fetal gestation
    Authors: TA Norman, AC Gower, F Chen, A Fine
    PLoS ONE, 2019-05-13;14(5):e0216795.
    Species: Mouse
    Sample Types: fetal lung tissue
    Applications: IHC-P
  39. Molecular Signature of Prospero Homeobox 1 (PROX1) in Follicular Thyroid Carcinoma Cells
    Authors: M Rudzi?ska, M Grzanka, A Stachurska, M Mikula, K Paczkowska, T St?pie?, A Paziewska, J Ostrowski, B Czarnocka
    Int J Mol Sci, 2019-05-05;20(9):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  40. Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development
    Authors: RMJ Genga, EM Kernfeld, KM Parsi, TJ Parsons, MJ Ziller, R Maehr
    Cell Rep, 2019-04-16;27(3):708-718.e10.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  41. CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
    Authors: JV Pluvinage, MS Haney, BAH Smith, J Sun, T Iram, L Bonanno, L Li, DP Lee, DW Morgens, AC Yang, SR Shuken, D Gate, M Scott, P Khatri, J Luo, CR Bertozzi, MC Bassik, T Wyss-Coray
    Nature, 2019-04-03;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  42. PDK1 Deficit Impairs the Development of the Dentate Gyrus in Mice
    Authors: M Xu, X Han, R Liu, Y Li, C Qi, Z Yang, C Zhao, J Gao
    Cereb. Cortex, 2019-03-01;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  43. Gq-coupled muscarinic receptor enhancement of KCNQ2/3 channels and activation of TRPC channels in multimodal control of excitability in dentate gyrus granule cells
    Authors: CM Carver, MS Shapiro
    J. Neurosci., 2018-12-28;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  44. Downregulation of VEGFR3 signaling alters cardiac lymphatic vessel organization and leads to a higher mortality after acute myocardial infarction
    Authors: T Vuorio, E Ylä-Herttu, JP Laakkonen, S Laidinen, T Liimataine, S Ylä-Herttu
    Sci Rep, 2018-11-12;8(1):16709.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  45. Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/?-Catenin Signaling
    Authors: B Cha, X Geng, MR Mahamud, JY Zhang, L Chen, W Kim, EH Jho, Y Kim, D Choi, JB Dixon, H Chen, YK Hong, L Olson, TH Kim, BJ Merrill, MJ Davis, RS Srinivasan
    Cell Rep, 2018-10-16;25(3):571-584.e5.
    Species: Human, Mouse
    Sample Types: Cell Lysates, Whole Tissue
    Applications: IHC, Western Blot
  46. Transcription factor PROX1 suppresses Notch pathway activation via the nucleosome remodeling and deacetylase complex in colorectal cancer stem-like cells
    Authors: J Högström, S Heino, P Kallio, M Lähde, VM Leppänen, D Balboa, Z Wiener, K Alitalo
    Cancer Res., 2018-08-28;0(0):.
    Species: Mouse
    Sample Types: Organoids
    Applications: Flow Cytometry
  47. Reduced expression of PROX1 transitions glioblastoma cells into a mesenchymal gene expression subtype
    Authors: KM Goudarzi, JA Espinoza, M Guo, J Bartek, M Nistér, MS Lindström, D Hägerstran
    Cancer Res., 2018-08-22;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Western Blot
  48. PROX1 is a transcriptional regulator of MMP14
    Authors: S Gramolelli, J Cheng, I Martinez-C, M Vähä-Koske, E Elbasani, E Kaivanto, V Rantanen, K Tuohinto, S Hautaniemi, M Bower, C Haglund, K Alitalo, T Mäkinen, TV Petrova, K Lehti, PM Ojala
    Sci Rep, 2018-06-22;8(1):9531.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: ChIP, Western Blot
  49. Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program
    Authors: M Frye, A Taddei, C Dierkes, I Martinez-C, M Fielden, H Ortsäter, J Kazenwadel, DP Calado, P Ostergaard, M Salminen, L He, NL Harvey, F Kiefer, T Mäkinen
    Nat Commun, 2018-04-17;9(1):1511.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  50. Neurogliaform cortical interneurons derive from cells in the preoptic area
    Authors: M Niquille, G Limoni, F Markopoulo, C Cadilhac, J Prados, A Holtmaat, A Dayer
    Elife, 2018-03-20;7(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  51. Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease
    Authors: S Rhee, JI Chung, DA King, G D'amato, DT Paik, A Duan, A Chang, D Nagelberg, B Sharma, Y Jeong, M Diehn, JC Wu, AJ Morrison, K Red-Horse
    Nat Commun, 2018-01-25;9(1):368.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  52. The role of prospero homeobox 1 (PROX1) expression in follicular thyroid carcinoma cells
    Authors: M Rudzinska, JK Ledwon, D Gawel, J Sikorska, B Czarnocka
    Oncotarget, 2017-12-12;8(69):114136-114155.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  53. Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma
    Authors: J Kim, DY Park, H Bae, DY Park, D Kim, CK Lee, S Song, TY Chung, DH Lim, Y Kubota, YK Hong, Y He, HG Augustin, G Oliver, GY Koh
    J. Clin. Invest., 2017-09-18;0(0):.
    Species: Human, Mouse
    Sample Types: Cell Lysates, Whole Cells, Whole Tissue
    Applications: ICC, IHC, Western Blot
  54. Arf6 in lymphatic endothelial cells regulates lymphangiogenesis by controlling directional cell migration
    Authors: YC Lin, N Ohbayashi, T Hongu, N Katagiri, Y Funakoshi, H Lee, Y Kanaho
    Sci Rep, 2017-09-12;7(1):11431.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  55. High PROX1 expression in gastric cancer predicts better survival
    Authors: A Laitinen, C Böckelman, J Hagström, A Kokkola, P Kallio, C Haglund
    PLoS ONE, 2017-08-30;12(8):e0183868.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  56. VIPAR, a quantitative approach to 3D histopathology applied to lymphatic malformations
    Authors: R Hägerling, D Drees, A Scherzinge, C Dierkes, S Martin-Alm, S Butz, K Gordon, M Schäfers, K Hinrichs, P Ostergaard, D Vestweber, T Goerge, S Mansour, X Jiang, PS Mortimer, F Kiefer
    JCI Insight, 2017-08-17;2(16):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  57. Dynamics and function of CXCR4 in formation of the granule cell layer during hippocampal development
    Authors: Y Mimura-Yam, H Shinohara, T Kashiwagi, T Sato, S Shioda, T Seki
    Sci Rep, 2017-07-17;7(1):5647.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  58. Development and Characterization of A Novel Prox1-EGFP Lymphatic and Schlemm's Canal Reporter Rat
    Authors: E Jung, D Gardner, D Choi, E Park, Y Jin Seong, S Yang, J Castorena-, A Louveau, Z Zhou, GK Lee, DP Perrault, S Lee, M Johnson, G Daghlian, M Lee, Y Jin Hong, Y Kato, J Kipnis, MJ Davis, AK Wong, YK Hong
    Sci Rep, 2017-07-17;7(1):5577.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: IHC
  59. Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1
    Authors: SK Jha, K Rauniyar, T Karpanen, VM Leppänen, P Brouillard, M Vikkula, K Alitalo, M Jeltsch
    Sci Rep, 2017-07-07;7(1):4916.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  60. Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity
    Authors: KS Yan, O Gevaert, GXY Zheng, B Anchang, CS Probert, KA Larkin, PS Davies, ZF Cheng, JS Kaddis, A Han, K Roelf, RI Calderon, E Cynn, X Hu, K Mandleywal, J Wilhelmy, SM Grimes, DC Corney, SC Boutet, JM Terry, P Belgrader, SB Ziraldo, TS Mikkelsen, F Wang, RJ von Furste, NR Smith, P Chandrakes, R May, MAS Chrissy, R Jain, CA Cartwright, JC Niland, YK Hong, J Carrington, DT Breault, J Epstein, CW Houchen, JP Lynch, MG Martin, SK Plevritis, C Curtis, HP Ji, L Li, SJ Henning, MH Wong, CJ Kuo
    Cell Stem Cell, 2017-07-06;21(1):78-90.e6.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr, IHC-P
  61. Lymphatic endothelial progenitors originate from plastic myeloid cells activated by toll-like receptor-4
    Authors: LD Volk-Drape, KL Hall, AC Wilber, S Ran
    PLoS ONE, 2017-06-09;12(6):e0179257.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  62. Fluorescence and Bioluminescence Imaging of Angiogenesis in Flk1-Nano-lantern Transgenic Mice
    Authors: J Matsushita, S Inagaki, T Nishie, T Sakasai, J Tanaka, C Watanabe, KI Mizutani, Y Miwa, K Matsumoto, K Takara, H Naito, H Kidoya, N Takakura, T Nagai, S Takahashi, M Ema
    Sci Rep, 2017-04-20;7(0):46597.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  63. Human umbilical cord plasma proteins revitalize hippocampal function in aged mice
    Authors: JM Castellano, KI Mosher, RJ Abbey, AA McBride, ML James, D Berdnik, JC Shen, B Zou, XS Xie, M Tingle, IV Hinkson, MS Angst, T Wyss-Coray
    Nature, 2017-04-19;544(7651):488-492.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  64. BIG1 is required for the survival of deep layer neurons, neuronal polarity, and the formation of axonal tracts between the thalamus and neocortex in developing brain
    Authors: JJ Teoh, T Iwano, M Kunii, N Atik, E Avriyanti, SI Yoshimura, K Moriwaki, A Harada
    PLoS ONE, 2017-04-17;12(4):e0175888.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  65. Peg3/PW1 is a marker of a subset of vessel associated endothelial progenitors
    Authors: M Malinverno, M Corada, L Ferrarini, L Formicola, G Marazzi, D Sassoon, E Dejana
    Stem Cells, 2017-02-05;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  66. Transcriptomic and anatomic parcellation of 5-HT3AR expressing cortical interneuron subtypes revealed by single-cell RNA sequencing
    Authors: S Frazer, J Prados, M Niquille, C Cadilhac, F Markopoulo, L Gomez, U Tomasello, L Telley, A Holtmaat, D Jabaudon, A Dayer
    Nat Commun, 2017-01-30;8(0):14219.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  67. Gene-expression profiling of different arms of lymphatic vasculature identifies candidates for manipulation of cell traffic
    Proc Natl Acad Sci USA, 2016-09-06;113(38):10643-10648.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: IHC
  68. Lymphatic vessels regulate immune microenvironments in human and murine melanoma
    J Clin Invest, 2016-08-15;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  69. Mechanotransduction activates canonical Wnt/?-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves
    Authors: Boksik Cha
    Genes Dev, 2016-06-16;30(12):1454-69.
    Species: Human, Mouse
    Sample Types: Cell Lysates, Whole Tissue
    Applications: IHC-Fr, Western Blot
  70. Foxc1 and Foxc2 deletion causes abnormal lymphangiogenesis and correlates with ERK hyperactivation
    J Clin Invest, 2016-05-23;0(0):.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: Flow Cytometry, IHC-P
  71. CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity
    J Clin Invest, 2016-05-03;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  72. Comprehensive Expression of Wnt Signaling Pathway Genes during Development and Maturation of the Mouse Cochlea.
    Authors: Geng R, Noda T, Mulvaney J, Lin V, Edge A, Dabdoub A
    PLoS ONE, 2016-02-09;11(2):e0148339.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: IHC
  73. Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development.
    Authors: Geng X, Cha B, Mahamud M, Lim K, Silasi-Mansat R, Uddin M, Miura N, Xia L, Simon A, Engel J, Chen H, Lupu F, Srinivasan R
    Dev Biol, 2015-11-02;409(1):218-33.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  74. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules.
    Authors: Aspelund A, Antila S, Proulx S, Karlsen T, Karaman S, Detmar M, Wiig H, Alitalo K
    J Exp Med, 2015-06-15;212(7):991-9.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  75. A transgenic Prox1-Cre-tdTomato reporter mouse for lymphatic vessel research.
    Authors: Bianchi R, Teijeira A, Proulx S, Christiansen A, Seidel C, Rulicke T, Makinen T, Hagerling R, Halin C, Detmar M
    PLoS ONE, 2015-04-07;10(4):e0122976.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  76. The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel.
    Authors: Aspelund A, Tammela T, Antila S, Nurmi H, Leppanen V, Zarkada G, Stanczuk L, Francois M, Makinen T, Saharinen P, Immonen I, Alitalo K
    J Clin Invest, 2014-07-25;124(9):3975-86.
    Species: Human, Zebrafish
    Sample Types: Whole Tissue
    Applications: IHC, IHC-P
  77. Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity.
    Authors: Park D, Lee J, Park I, Choi D, Lee S, Song S, Hwang Y, Hong K, Nakaoka Y, Makinen T, Kim P, Alitalo K, Hong Y, Koh G
    J Clin Invest, 2014-07-25;124(9):3960-74.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  78. Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions.
    Authors: Zheng W, Nurmi H, Appak S, Sabine A, Bovay E, Korhonen E, Orsenigo F, Lohela M, D'Amico G, Holopainen T, Leow C, Dejana E, Petrova T, Augustin H, Alitalo K
    Genes Dev, 2014-07-15;28(14):1592-603.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  79. Bone marrow-derived cells are implicated as a source of lymphatic endothelial progenitors in human breast cancer.
    Authors: Van't Hull E, Bron S, Henry L, Ifticene-Treboux A, Turrini R, Coukos G, Delaloye J, Doucey M
    Oncoimmunology, 2014-06-25;3(0):e29080.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  80. Murine Notch1 is required for lymphatic vascular morphogenesis during development.
    Authors: Fatima A, Culver A, Culver F, Liu T, Dietz W, Thomson B, Hadjantonakis A, Quaggin S, Kume T
    Dev Dyn, 2014-04-17;243(7):957-64.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  81. Blimp1 (Prdm1) prevents re-specification of photoreceptors into retinal bipolar cells by restricting competence.
    Authors: Brzezinski J, Uoon Park K, Reh T
    Dev Biol, 2013-10-12;384(2):194-204.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  82. The germinal matrices in the developing dentate gyrus are composed of neuronal progenitors at distinct differentiation stages.
    Authors: Sugiyama T, Osumi N, Katsuyama Y
    Dev Dyn, 2013-10-07;242(12):1442-53.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  83. A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy.
    Authors: Hagerling R, Pollmann C, Andreas M, Schmidt C, Nurmi H, Adams R, Alitalo K, Andresen V, Schulte-Merker S, Kiefer F
    EMBO J, 2013-01-08;32(5):629-44.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  84. Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis.
    Blood, 2012-04-30;119(24):5931-42.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC-P
  85. Mcl-1 and Bcl-x(L) coordinately regulate megakaryocyte survival.
    Blood, 2012-02-28;119(24):5850-8.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  86. Expression and prognostic value of transcription factor PROX1 in colorectal cancer.
    Authors: Skog M, Bono P, Lundin M, Lundin J, Louhimo J, Linder N, Petrova TV, Andersson LC, Joensuu H, Alitalo K, Haglund CH
    Br. J. Cancer, 2011-10-04;105(9):1346-51.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  87. CKIalpha ablation highlights a critical role for p53 in invasiveness control.
    Authors: Elyada E, Pribluda A, Goldstein RE, Morgenstern Y, Brachya G, Cojocaru G, Snir-Alkalay I, Burstain I, Haffner-Krausz R, Jung S, Wiener Z, Alitalo K, Oren M, Pikarsky E, Ben-Neriah Y
    Nature, 2011-02-17;470(7334):409-13.
    Species: Mouse
    Sample Types: Cell Lysates, Whole Tissue
    Applications: IHC-P, Western Blot
  88. Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase.
    Authors: Philipp M, Fralish GB, Meloni AR, Chen W, MacInnes AW, Barak LS, Caron MG
    Mol. Biol. Cell, 2008-09-24;19(12):5478-89.
    Species: Zebrafish
    Sample Types: Whole Tissue
    Applications: IHC
  89. The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis.
    Authors: Heckman CA, Holopainen T, Wirzenius M, Keskitalo S, Jeltsch M, Yla-Herttuala S, Wedge SR, Jurgensmeier JM, Alitalo K
    Cancer Res., 2008-06-15;68(12):4754-62.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC

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Human Prox1 Antibody
By Anonymous on 08/10/2017
Application: ICC/IF Sample Tested: Embryonic kidney Species: Mouse
Immunocytochemistry/Immunofluorescence Human Prox1 Antibody AF2727