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Human/Rat CCR4 PE-conjugated Antibody

Catalog #: FAB1567P
21 Citations Datasheet / COA / SDS
Clone 205410 was used by HLDA to establish CD designation
Catalog # Availability Size / Price Qty
FAB1567P-025
FAB1567P-100
Detection of CCR4 in Human Blood Lymphocytes by Flow Cytometry.
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Product Details
Citations (21)
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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human/Rat CCR4 PE-conjugated Antibody Summary

Species Reactivity
Human, Rat
Specificity
Stains human CCR4-transfected cell lines but not the corresponding parent cell lines. Also detects human CCR4 on human PBLs and platelets and rat CCR4 on rat splenocytes.
Source
Monoclonal Mouse IgG2B Clone # 205410
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Human CCR4 transfectants
Met1-Leu360
Accession # P51679
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Phycoerythrin (Excitation= 488 nm, Emission= 565-605 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of CCR4 antibody in Human Blood Lymphocytes antibody by Flow Cytometry. View Larger

Detection of CCR4 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human CD3e APC-conjugated Monoclonal Antibody (Catalog # FAB100A) and either (A) Mouse Anti-Human/Rat CCR4 PE-conjugated Monoclonal Antibody (Catalog # FAB1567P) or (B) Mouse IgG2BPhycoerythrin Isotype Control (Catalog # IC0041P). View our protocol for Staining Membrane-associated Proteins.

Flow Cytometry Detection of CCR4 antibody in Rat Peripheral Blood Cells antibody by Flow Cytometry. View Larger

Detection of CCR4 in Rat Peripheral Blood Cells by Flow Cytometry. Rat peripheral blood cells were stained with Mouse Anti-Human/Rat CCR4 PE-conjugated Monoclonal Antibody (Catalog # FAB1567P, filled histogram) or isotype control antibody (Catalog # IC0041P, open histogram). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: CCR4

CCR4 is a G protein-linked seven transmembrane domain chemokine receptor that binds the chemokines CCL17/TARC and CCL22/MDC. Current evidence suggests that CCR4 expression is associated with Th-2 type T cells and with platelets. CCR4 expression has also been reported in mature dendritic cells.

Entrez Gene IDs
1233 (Human); 12773 (Mouse); 171054 (Rat); 403541 (Canine); 102120178 (Cynomolgus Monkey)
Alternate Names
C-C chemokine receptor type 4; C-C CKR-4; CC-CKR-4HGCN:14099; CCR4; CCR-4; CD194 antigen; CD194; chemokine (C-C motif) receptor 4; chemokine (C-C) receptor 4; ChemR13; CKR4MGC88293; CMKBR4k5-5; K5-5

Product Datasheets

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Citations for Human/Rat CCR4 PE-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

21 Citations: Showing 1 - 10
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  1. A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.
    Authors: Berlato C, Khan MN, Schioppa T et al.
    J. Clin. Invest.
  2. Blocking interleukin-23 ameliorates neuromuscular and thymic defects in myasthenia gravis
    Authors: JA Villegas, J Van Wassen, J Merrheim, K Matta, S Hamadache, C Flaugère, P Pothin, F Truffault, S Hascoët, N Santelmo, M Alifano, S Berrih-Akn, R le Panse, N Dragin
    Journal of Neuroinflammation, 2023-01-13;20(1):9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  3. Role of CXCL13 and CCL20 in the recruitment of B cells to inflammatory foci in chronic arthritis
    Authors: E Armas-Gonz, MJ Domínguez-, A Díaz-Martí, M Arce-Franc, J Castro-Her, G Danelon, V Hernández-, S Bustabad-R, A Cantabrana, M Uguccioni, F Díaz-Gonzá
    Arthritis Res. Ther., 2018-06-07;20(1):114.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  4. Porcine Treg depletion with a novel diphtheria toxin-based anti-human CCR4 immunotoxin
    Authors: Zhirui Wang
    Vet. Immunol. Immunopathol., 2016-10-29;182(0):150-158.
    Species: Porcine
    Sample Types: Whole Blood
    Applications: Flow Cytometry
  5. Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity
    Authors: Lee Faulkner
    Toxicol. Sci, 2016-09-16;154(2):416-429.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  6. Transcriptional Profiling of Th2 Cells Identifies Pathogenic Features Associated with Asthma
    Authors: Grégory Seumois
    J Immunol, 2016-06-06;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  7. Treg depletion in non-human primates using a novel diphtheria toxin-based anti-human CCR4 immunotoxin
    Authors: Zhaohui Wang, Shannon G. Pratts, Huiping Zhang, Philip J. Spencer, Ruichao Yu, Makoto Tonsho et al.
    Molecular Oncology
  8. Aberrant CCR4 expression is involved in tumor invasion of lymph node-negative human gastric cancer.
    Authors: Yang, Yongmei, Du, Lutao, Yang, Xiaoyun, Qu, Ailin, Zhang, Xin, Zhou, Chengjun, Wang, Chuanxin
    PLoS ONE, 2015-03-19;10(3):e0120059.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  9. Chemokines as novel and versatile reagents for flow cytometry and cell sorting.
    Authors: Le Brocq M, Fraser A, Cotton G, Woznica K, McCulloch C, Hewit K, McKimmie C, Nibbs R, Campbell J, Graham G
    J Immunol, 2014-05-21;192(12):6120-30.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  10. Phase I clinical trial of multiple-peptide vaccination for patients with advanced biliary tract cancer.
    Authors: Aruga, Atsushi, Takeshita, Nobuhiro, Kotera, Yoshihit, Okuyama, Ryuji, Matsushita, Norimasa, Ohta, Takehiro, Takeda, Kazuyosh, Yamamoto, Masakazu
    J Transl Med, 2014-03-07;12(0):61.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  11. IL-27 in human secondary lymphoid organs attracts myeloid dendritic cells and impairs HLA class I-restricted antigen presentation.
    Authors: Morandi, Fabio, Di Carlo, Emma, Ferrone, Soldano, Petretto, Andrea, Pistoia, Vito, Airoldi, Irma
    J Immunol, 2014-02-19;192(6):2634-42.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  12. Circulating T regulatory cells migration and phenotype in glioblastoma patients: an in vitro study
    Authors: Chiara Vasco, Alessandra Canazza, Ambra Rizzo, Adele Mossa, Elena Corsini, Antonio Silvani et al.
    Journal of Neuro-Oncology
  13. Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver.
    Authors: Oo YH, Weston CJ, Lalor PF, Curbishley SM, Withers DR, Reynolds GM, Shetty S, Harki J, Shaw JC, Eksteen B, Hubscher SG, Walker LS, Adams DH
    J. Immunol., 2010-02-17;184(6):2886-98.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  14. CD56highCD16-CD62L- NK cells accumulate in allergic contact dermatitis and contribute to the expression of allergic responses.
    Authors: Carbone T, Nasorri F, Pennino D
    J. Immunol., 2009-12-11;184(2):1102-10.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  15. The Lupane-type Triterpene 30-Oxo-calenduladiol Is a CCR5 Antagonist with Anti-HIV-1 and Anti-chemotactic Activities.
    Authors: Barroso-Gonzalez J, El Jaber-Vazdekis N, Garcia-Exposito L, Machado JD, Zarate R, Ravelo AG, Estevez-Braun A, Valenzuela-Fernandez A
    J. Biol. Chem., 2009-04-22;284(24):16609-20.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  16. IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response.
    Authors: Eyerich K, Pennino D, Scarponi C, Foerster S, Nasorri F, Behrendt H, Ring J, Traidl-Hoffmann C, Albanesi C, Cavani A
    J. Allergy Clin. Immunol., 2008-12-03;123(1):59-66.e4.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  17. Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases.
    Authors: Hartl D, Krauss-Etschmann S, Koller B, Hordijk PL, Kuijpers TW, Hoffmann F, Hector A, Eber E, Marcos V, Bittmann I, Eickelberg O, Griese M, Roos D
    J. Immunol., 2008-12-01;181(11):8053-67.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  18. Chemokine receptors in head and neck cancer: association with metastatic spread and regulation during chemotherapy.
    Authors: Muller A, Sonkoly E, Eulert C, Gerber PA, Kubitza R, Schirlau K, Franken-Kunkel P, Poremba C, Snyderman C, Klotz LO, Ruzicka T, Bier H, Zlotnik A, Whiteside TL, Homey B, Hoffmann TK
    Int. J. Cancer, 2006-05-01;118(9):2147-57.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  19. Chemokine receptor expression in EBV-associated lymphoproliferation in hu/SCID mice: implications for CXCL12/CXCR4 axis in lymphoma generation.
    Authors: Piovan E, Tosello V, Indraccolo S, Cabrelle A, Baesso I, Trentin L, Zamarchi R, Tamamura H, Fujii N, Semenzato G, Chieco-Bianchi L, Amadori A
    Blood, 2004-09-28;105(3):931-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  20. Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis.
    Authors: Casazza S, Zappia E, Pistorio A, Gambini C
    Proc. Natl. Acad. Sci. U.S.A., 2004-07-19;101(30):11064-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  21. Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS.
    Authors: Giunti D, Borsellino G, Benelli R, Marchese M, Capello E, Valle MT, Pedemonte E, Noonan D, Albini A, Bernardi G, Mancardi GL, Battistini L, Uccelli A
    J. Leukoc. Biol., 2003-05-01;73(5):584-90.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry

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