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Human STRO-1 Antibody

Catalog #: MAB1038
39 Citations 2 Reviews Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB1038
MAB1038-SP
STRO‑1 in Human MG‑63 Cell Line.
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Citations (39)
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Reviews (2)
Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human STRO-1 Antibody Summary

Species Reactivity
Human
Specificity
Detects human STRO-1.
Source
Monoclonal Mouse IgM Clone # STRO-1
Purification
IgM-specific Affinity-purified from hybridoma culture supernatant
Immunogen
Human CD34+ bone marrow cells
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Flow Cytometry
2.5 µg/106 cells
MG‑63 human osteosarcoma cell line
CyTOF-ready
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
 
Immunocytochemistry
8-25 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunocytochemistry STRO-1 antibody in Human MG-63 Cell Line by Immunocytochemistry (ICC). View Larger

STRO‑1 in Human MG‑63 Cell Line. STRO-1 was detected in immersion fixed MG-63 human osteosarcoma cell line using Human STRO-1 Monoclonal Antibody (Catalog # MAB1038) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgM Secondary Antibody (red; Catalog # NL019) (Catalog # NL019), and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: STRO-1

STRO-1 is a cell surface protein expressed by bone marrow stromal cells and erythroid precursors. The frequency of colony forming units-fibroblasts (CFU-F) was enriched 100-fold in the STRO-1+/Glycophorin A- population from bone marrow cells (1). The subset of marrow cells that expresses the STRO-1 antigen is capable of differentiating into multiple mesenchymal lineages including hematopoiesis-supportive stromal cells with a vascular smooth muscle-like phenotype, adipocytes, osteoblasts, and chondrocytes (2).

References
  1. Simmons, P.J. and B. Torok-Storb (1991) Blood 78:55.
  2. Dennis, J.E. et al. (2002) Cells Tissues Organs 170:73.
Long Name
A Stromal Cell Precursor Surface Antigen
Alternate Names
STRO1; STRO-1

Product Datasheets

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Citations for Human STRO-1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

39 Citations: Showing 1 - 10
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  1. Nerve growth factor promote osteogenic differentiation of dental pulp stem cells through MEK/ERK signalling pathways
    Authors: Cheng, C;Tang, S;Cui, S;Yang, T;Li, L;Zhai, M;Wei, F;Ding, G;
    Journal of cellular and molecular medicine
    Species: Human hepegivirus
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  2. Influence of Ascorbic Acid as a Growth and Differentiation Factor on Dental Stem Cells Used in Regenerative Endodontic Therapies
    Authors: A Diederich, HJ Fründ, B Trojanowic, A Navarrete, AD Nguyen, C Hoang-Vu, CR Gernhardt
    Journal of Clinical Medicine, 2023-02-02;12(3):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  3. A Clinical Study of Alveolar Bone Tissue Engineering Using Autologous Bone Marrow Stromal Cells: Effect of Optimized Cell-Processing Protocol on Efficacy
    Authors: H Kagami, M Inoue, H Agata, I Asahina, T Nagamura-I, M Taguri, A Tojo
    Journal of Clinical Medicine, 2022-12-09;11(24):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  4. Enamel Matrix Derivative Enhances the Odontoblastic Differentiation of Dental Pulp Stem Cells via Activating MAPK Signaling Pathways
    Authors: B Zhang, M Xiao, X Cheng, Y Bai, H Chen, Q Yu, L Qiu
    Stem Cells International, 2022-04-28;2022(0):2236250.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  5. Treated dentin matrix induces odontogenic differentiation of dental pulp stem cells via regulation of Wnt/beta-catenin signaling
    Authors: S Liu, J Sun, S Yuan, Y Yang, Y Gong, Y Wang, R Guo, X Zhang, Y Liu, H Mi, M Wang, M Liu, R Li
    Bioactive materials, 2021-06-05;7(0):85-97.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  6. A pilot study on biological characteristics of human CD24(+) stem cells from the apical papilla
    Authors: J Liang, YJ Zhao, JQ Li, L Lan, WJ Tao, JY Wu
    Journal of dental sciences, 2021-04-24;17(1):264-275.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  7. Cellular response of human apical papilla cells to calcium hydroxide and tricalcium silicate-based cements
    Authors: M Garrido, D Morales, MP Saldías, C Fernández, V Villalobos, O Cerda, M Cáceres
    BMC Oral Health, 2021-03-09;21(1):106.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  8. R-Spondin 2 Induces Odontogenic Differentiation of Dental Pulp Stem/Progenitor Cells via Regulation of Wnt/beta-Catenin Signaling
    Authors: Y Gong, S Yuan, J Sun, Y Wang, S Liu, R Guo, W Dong, R Li
    Front Physiol, 2020-08-07;11(0):918.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  9. EphrinB2 overexpression enhances osteogenic differentiation of dental pulp stem cells partially through ephrinB2-mediated reverse signaling
    Authors: W Wang, C Yuan, T Geng, Y Liu, S Zhu, C Zhang, Z Liu, P Wang
    Stem Cell Res Ther, 2020-01-29;11(1):40.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  10. Fluoxetine induces direct inhibitory effects on mesenchymal stem cell?derived osteoprogenitor cells independent of serotonin concentration
    Authors: SM Koura, M Salama, M El-Hussiny, MEA Khalil, A Lotfy, SA Hassan, SA Gad Elhak, MA Sobh
    Mol Med Rep, 2019-02-01;0(0):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  11. Identifying deer antler uhrf1 proliferation and s100a10 mineralization genes using comparative RNA-seq
    Authors: DFE Ker, D Wang, R Sharma, B Zhang, B Passarelli, N Neff, C Li, W Maloney, S Quake, YP Yang
    Stem Cell Res Ther, 2018-10-31;9(1):292.
    Species: Deer
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  12. Safety and efficacy of the mesenchymal stem cell in feline eosinophilic keratitis treatment
    Authors: AJ Villatoro, S Claros, V Fernández, C Alcoholado, F Fariñas, A Moreno, J Becerra, JA Andrades
    BMC Vet. Res., 2018-03-27;14(1):116.
    Species: Feline
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  13. Evaluating Interaction of Cord Blood Hematopoietic Stem/Progenitor Cells with Functionally Integrated Three-Dimensional Microenvironments
    Authors: S Mokhtari, PM Baptista, DA Vyas, CJ Freeman, E Moran, M Brovold, GA Llamazares, Z Lamar, CD Porada, S Soker, G Almeida-Po
    Stem Cells Transl Med, 2018-02-23;7(3):271-282.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Selection
  14. Ganglioside GM1 contributes to extracellular/intracellular regulation of insulin resistance, impairment of insulin signaling and down-stream eNOS activation, in human aortic endothelial cells after short- or long-term exposure to TNF?
    Authors: N Sasaki, Y Itakura, M Toyoda
    Oncotarget, 2017-12-15;9(5):5562-5577.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  15. In-vitro characterization of canine multipotent stromal cells isolated from synovium, bone marrow, and adipose tissue: a donor-matched comparative study
    Authors: RN Bearden, SS Huggins, KJ Cummings, R Smith, CA Gregory, WB Saunders
    Stem Cell Res Ther, 2017-10-03;8(1):218.
    Species: Canine
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  16. Human Dental Pulp Cells Differentiate toward Neuronal Cells and Promote Neuroregeneration in Adult Organotypic Hippocampal Slices In Vitro
    Authors: L Xiao, R Ide, C Saiki, Y Kumazawa, H Okamura
    Int J Mol Sci, 2017-08-11;18(8):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  17. A monoclonal antibody recognizes undifferentiation-specific carbohydrate moieties expressed on cell surface of the human dental pulp cells
    Authors: KJ Kang, SY Ko, CJ Ryu, YJ Jang
    Stem Cell Res, 2017-04-06;21(0):85-93.
    Species: Human
    Sample Types: Tissue Homogenates
    Applications: Flow Cytometry
  18. The Mesenchymal Precursor Cell Marker Antibody STRO-1 Binds to Cell Surface Heat Shock Cognate 70
    Stem Cells, 2017-01-23;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  19. In vivo experimental model of orthotopic dental pulp regeneration under the influence of photobiomodulation therapy
    Authors: Maria Stella Moreira
    J. Photochem. Photobiol. B, Biol, 2016-12-02;166(0):180-186.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: IHC-P
  20. ?-Catenin Accumulation Is Associated With Increased Expression of Nanog Protein and Predicts Maintenance of MSC Self-Renewal
    Authors: SJ Yu, HJ Kim, ES Lee, CG Park, SJ Cho, SH Jeon
    Cell Transplant, 2016-09-27;26(2):365-377.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  21. The differentiation potential of gingival mesenchymal stem cells induced by apical tooth germ cell?conditioned medium
    Mol Med Rep, 2016-09-06;14(4):3565-72.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  22. Immobilized WNT Proteins Act as a Stem Cell Niche for Tissue Engineering
    Stem Cell Reports, 2016-07-12;7(1):126-37.
    Species: Human
    Sample Types: Whole Cells
    Applications: IHC
  23. Restoration of a Critical Mandibular Bone Defect Using Human Alveolar Bone-Derived Stem Cells and Porous Nano-HA/Collagen/PLA Scaffold
    Authors: X Wang, H Xing, G Zhang, X Wu, X Zou, L Feng, D Wang, M Li, J Zhao, J Du, Y Lv, L E, H Liu
    Stem Cells Int, 2016-03-28;2016(0):8741641.
    Species: Human
    Sample Types: Whole Cells
    Applications: IHC-Fr
  24. Interferon-gamma improves impaired dentinogenic and immunosuppressive functions of irreversible pulpitis-derived human dental pulp stem cells.
    Authors: Sonoda S, Yamaza H, Ma L, Tanaka Y, Tomoda E, Aijima R, Nonaka K, Kukita T, Shi S, Nishimura F, Yamaza T
    Sci Rep, 2016-01-18;6(0):19286.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  25. Wnts enhance neurotrophin-induced neuronal differentiation in adult bone-marrow-derived mesenchymal stem cells via canonical and noncanonical signaling pathways.
    Authors: Tsai H, Deng W, Lai W, Chiu W, Yang C, Tsai Y, Hwang S, Renshaw P
    PLoS ONE, 2014-08-29;9(8):e104937.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  26. Human fetal and adult bone marrow-derived mesenchymal stem cells use different signaling pathways for the initiation of chondrogenesis.
    Authors: Brady K, Dickinson S, Guillot P, Polak J, Blom A, Kafienah W, Hollander A
    Stem Cells Dev, 2013-12-04;23(5):541-54.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  27. Mesenchymal stem cells engineered to inhibit complement-mediated damage.
    Authors: Soland M, Bego M, Colletti E, Zanjani E, St Jeor S, Porada C, Almeida-Porada G
    PLoS ONE, 2013-03-26;8(3):e60461.
    Species: Human
    Sample Types: Tissue Homogenates
    Applications: Cell Selection
  28. Intercellular transport of Oct4 in mammalian cells: a basic principle to expand a stem cell niche?
    Authors: Rolf HJ, Niebert S, Niebert M, Gaus L, Schliephake H, Wiese KG
    PLoS ONE, 2012-02-16;7(2):e32287.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  29. Characterization of mesenchymal progenitor cells isolated from human bone marrow by negative selection.
    Authors: Modder UI, Roforth MM, Nicks KM, Peterson JM, McCready LK, Monroe DG, Khosla S
    Bone, 2011-12-28;50(3):804-10.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  30. High levels of beta-catenin signaling reduce osteogenic differentiation of stem cells in inflammatory microenvironments through inhibition of the noncanonical Wnt pathway.
    Authors: Liu N, Shi S, Deng M, Tang L, Zhang G, Liu N, Ding B, Liu W, Liu Y, Shi H, Liu L, Jin Y
    J. Bone Miner. Res., 2011-09-01;26(9):2082-95.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  31. Synovial sarcoma is a stem cell malignancy.
    Authors: Naka N, Takenaka S, Araki N
    Stem Cells, 2010-07-01;28(7):1119-31.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  32. Multipotent mesenchymal stem cells from human placenta: critical parameters for isolation and maintenance of stemness after isolation.
    Authors: Semenov O, Koestenbauer S, Riegel M, Zech N, Zimmermann R, Zisch A, Malek A
    Am J Obstet Gynecol, 2009-12-24;202(2):193.e1-193.e1.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  33. Three-dimensional reconstituted extracellular matrix scaffolds for tissue engineering.
    Authors: Narayanan K, Leck KJ, Gao S, Wan AC
    Biomaterials, 2009-05-28;30(26):4309-17.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  34. Stem cells from deciduous tooth repair mandibular defect in swine.
    Authors: Zheng Y, Liu Y, Zhang CM
    J. Dent. Res., 2009-03-01;88(3):249-54.
    Species: Porcine
    Sample Types: Whole Cells
    Applications: ICC
  35. Investigating a clonal human periodontal ligament progenitor/stem cell line in vitro and in vivo.
    Authors: Fujii S, Maeda H, Wada N, Tomokiyo A, Saito M, Akamine A
    J. Cell. Physiol., 2008-06-01;215(3):743-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  36. Promotion of attachment of human bone marrow stromal cells by CCN2.
    Authors: Ono M, Kubota S, Fujisawa T, Sonoyama W, Kawaki H, Akiyama K, Oshima M, Nishida T, Yoshida Y, Suzuki K, Takigawa M, Kuboki T
    Biochem. Biophys. Res. Commun., 2007-03-19;357(1):20-5.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  37. Phenotypic and functional characteristics of mesenchymal stem cells differentiated along a Schwann cell lineage.
    Authors: Caddick J, Kingham PJ, Gardiner NJ, Wiberg M, Terenghi G
    Glia, 2006-12-01;54(8):840-9.
    Species: Rat
    Sample Types: Whole Cells
    Applications: ICC
  38. Isolation and characterization of a stem cell population from adult human liver.
    Authors: Herrera MB, Bruno S, Buttiglieri S, Tetta C, Gatti S, Deregibus MC, Bussolati B, Camussi G
    Stem Cells, 2006-08-31;24(12):2840-50.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  39. Mechanical stress promotes the expression of smooth muscle-like properties in marrow stromal cells.
    Authors: Kobayashi N, Yasu T, Ueba H, Sata M, Hashimoto S, Kuroki M, Saito M, Kawakami M
    Exp. Hematol., 2004-12-01;32(12):1238-45.
    Species: Rat
    Sample Types: Whole Cells
    Applications: ICC

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Human STRO-1 Antibody
By Anonymous on 07/20/2021
Application: ICC/IF Sample Tested: Human dental pulp cells Species: Human
Immunocytochemistry/Immunofluorescence Human STRO-1 Antibody MAB1038
Human STRO-1 Antibody
By Anonymous on 07/02/2021
Application: ICC/IF Sample Tested: Stem cells Species: Human
Immunocytochemistry/Immunofluorescence Human STRO-1 Antibody MAB1038