Human ULBP-3 Antibody Summary
Gly27-Pro216
Accession # NP_078794
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: ULBP-3
ULBP-3 is a member of a family of cell-surface proteins that function as ligands for human NKG2D. ULBP-3 has also been described under the names RaeT1N (retinoic acid early transcript), NKG2DL3, and ALCAN-gamma. The name ULBP-3 derives from the original identification of three proteins, ULBP-1, -2, and -3, as ligands for the human cytomegalovirus glycoprotein UL16; they were designated UL16 binding proteins (ULBP). The gene for ULBP-3 resides in a cluster of ten related genes, six of which encode potentially functional glycoproteins. Amino acid sequence identity within this family ranges from 30-60%. These proteins are distantly related to MHC class I proteins, but they possess only the alpha 1 and alpha 2 Ig-like domains, and they have no capacity to bind peptide or interact with beta 2‑microglobulin. Some family members, including ULBP-3, are anchored to the membrane via a GPI-linkage, whereas others have transmembrane domains. ULBP‑3 and several other family members are known to bind to human NKG2D, an activating receptor expressed on NK cells, NKT cells, gamma δ T cells, and CD8+ alpha beta T cells. Engagement of NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. The ULBPs are expressed on some tumor cells and have been implicated in tumor surveillance (1-7).
- Cosman, D. et al. (2001) Immunity 14:123.
- Kubin, M. et al. (2001) Eur. J. Immunol. 31:1428.
- Sutherland, C. et al. (2002) J. Immunol. 168:671.
- Steinle, A. et al. (2001) Immunogenetics 53:279.
- Sutherland, C. et al. (2001) Immunol. Rev. 181:185.
- Pende, D. et al. (2002) Cancer Res. 62:6178.
- Radosavljevic, M. et al. (2002) Genomics 79:114.
- NKG2D and its Ligands (2002) http://www.RnDSystems.com/.
Product Datasheets
Citations for Human ULBP-3 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Soluble NKG2DLs Are Elevated in Breast Cancer Patients and Associate with Disease Outcome
Authors: Seller, A;Tegeler, CM;Mauermann, J;Schreiber, T;Hagelstein, I;Liebel, K;Koch, A;Heitmann, JS;Greiner, SM;Hayn, C;Dannehl, D;Engler, T;Hartkopf, AD;Hahn, M;Brucker, SY;Salih, HR;Märklin, M;
International journal of molecular sciences
Species: Human
Sample Types: Serum
Applications: ELISA Capture -
CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity
Authors: J Joung, PC Kirchgatte, A Singh, JH Cho, SP Nety, RC Larson, RK Macrae, R Deasy, YY Tseng, MV Maus, F Zhang
Nature Communications, 2022-03-25;13(1):1606.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Natural Killer Group 2D Ligand Depletion Reconstitutes Natural Killer Cell Immunosurveillance of Head and Neck Squamous Cell Carcinoma
Authors: S Weil, S Memmer, A Lechner, V Huppert, A Giannattas, T Becker, A Müller-Run, K Lampe, D Beutner, A Quaas, R Schubert, E Herrmann, A Steinle, U Koehl, L Walter, MS von Bergwe, J Koch
Front Immunol, 2017-04-10;8(0):387.
Applications: ELISA Development (Capture) -
Natural Killer Cell Evasion Is Essential for Infection by Rhesus Cytomegalovirus
PLoS Pathog, 2016-08-31;12(8):e1005868.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Cytotoxicity and infiltration of human NK cells in in vivo-like tumor spheroids.
Authors: Giannattasio A, Weil S, Kloess S, Ansari N, Stelzer E, Cerwenka A, Steinle A, Koehl U, Koch J
BMC Cancer, 2015-05-03;15(0):351.
Species: Human
Sample Types: Cell Culture Supernates
Applications: ELISA Development (Capture) -
Immunohistochemical validation and expression profiling of NKG2D ligands in a wide spectrum of human epithelial neoplasms.
Authors: Fujita H, Hatanaka Y, Sutoh Y, Suzuki Y, Oba K, Hatanaka K, Mitsuhashi T, Otsuka N, Fugo K, Kasahara M, Matsuno Y
J Histochem Cytochem, 2014-12-03;63(3):217-27.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
The human NKG2D ligand ULBP2 can be expressed at the cell surface with or without a GPI anchor and both forms can activate NK cells.
Authors: Fernandez-Messina L, Ashiru O, Aguera-Gonzalez S, Reyburn HT, Vales-Gomez M
J. Cell. Sci., 2011-01-11;124(0):321-7.
Species: Human
Sample Types: Whole Cells
Applications: ICC, Immunoprecipitation -
NKG2D ligand expression in human colorectal cancer reveals associations with prognosis and evidence for immunoediting.
Authors: McGilvray RW, Eagle RA, Watson NF, Al-Attar A, Ball G, Jafferji I, Trowsdale J, Durrant LG
Clin. Cancer Res., 2009-10-27;15(22):6993-7002.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P
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