Human VEGFR3/Flt-4 APC-conjugated Antibody Summary
Tyr25-Ile776
Accession # P35916
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of VEGF R3/Flt‑4 in HUVEC Human Cells by Flow Cytometry. HUVEC human umbilical vein endothelial cells were stained with Mouse Anti-Human VEGF R3/ Flt-4 APC-conjugated Monoclonal Antibody (Catalog # FAB3492A, filled histogram) or isotype control antibody (Catalog # IC002A, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: VEGFR3/Flt-4
VEGF R2 (KDR/Flk-1), VEGF R1 (Flt-1) and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domains and kinase insert domains in their intracellular regions. The expression of VEGF R1, 2, and 3 is almost exclusively restricted to the endothelial cells. These receptors are likely to play essential roles in vasculogenesis and angiogenesis.
VEGF R3 cDNA encodes a 1298 amino acid (aa) residue precursor protein with a 24 aa residue signal peptide. Mature VEGF R3 is composed of a 751 aa residue extracellular domain, a 22 aa residue transmembrane domain, and a 482 aa residue cytoplasmic domain. Both VEGF-C and VEGF-D have been shown to bind and activate VEGF R3 (Flt-4). VEGF R3 is widely expressed in the early embryo but becomes restricted to lymphatic endothelia at later stages of development. It is likely that VEGF R3 may be important for lymph angiogenesis.
Product Datasheets
Citations for Human VEGFR3/Flt-4 APC-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 8
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Atypical cadherin Fat4 orchestrates lymphatic endothelial cell polarity in response to flow
Authors: KL Betterman, DL Sutton, GA Secker, J Kazenwadel, A Oszmiana, L Lim, N Miura, L Sorokin, BM Hogan, ML Kahn, H McNeill, NL Harvey
J. Clin. Invest., 2020-06-01;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
The distribution and potential prognostic value of SMAD protein expression in chronic lymphocytic leukemia
Authors: M Witkowska, A Majchrzak, B Cebula-Obr, E Wawrzyniak, T Robak, P Smolewski
Tumour Biol, 2017-03-01;39(3):1010428317694.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Growth-factor-driven rescue to receptor tyrosine kinase (RTK) inhibitors through Akt and Erk phosphorylation in pediatric low grade astrocytoma and ependymoma.
Authors: Sie M, den Dunnen W, Lourens H, Meeuwsen-de Boer T, Scherpen F, Zomerman W, Kampen K, Hoving E, de Bont E
PLoS ONE, 2015-03-23;10(3):e0122555.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Differential sensitivity of prostate tumor derived endothelial cells to sorafenib and sunitinib.
Authors: Fiorio Pla, Alessand, Brossa, Alessia, Bernardini, Michela, Genova, Tullio, Grolez, Guillaum, Villers, Arnaud, Leroy, Xavier, Prevarskaya, Natalia, Gkika, Dimitra, Bussolati, Benedett
BMC Cancer, 2014-12-12;14(0):939.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Antiangiogenic cancer drug sunitinib exhibits unexpected proangiogenic effects on endothelial cells.
Authors: Norton, Kerri-An, Han, Zheyi, Popel, Aleksand, Pandey, Niranjan
Onco Targets Ther, 2014-09-09;7(0):1571-82.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Impaired long-term expansion and self-renewal potential of pediatric acute myeloid leukemia-initiating cells by PTK787/ZK 222584.
Authors: Weidenaar A, Ter Elst A, Kampen K, Meeuwsen-de Boer T, Kamps W, Schuringa J, de Bont E
Mol Cancer Res, 2013-02-07;11(4):339-48.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Multiple receptor tyrosine kinases regulate HIF-1alpha and HIF-2alpha in normoxia and hypoxia in neuroblastoma: implications for antiangiogenic mechanisms of multikinase inhibitors.
Authors: Nilsson MB, Zage PE, Zeng L, Xu L, Cascone T, Wu HK, Saigal B, Zweidler-McKay PA, Heymach JV
Oncogene, 2010-03-08;29(20):2938-49.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
VEGF-A promotes lymphoma tumour growth by activation of STAT proteins and inhibition of p27(KIP1) via paracrine mechanisms.
Authors: Roorda BD, Ter Elst A, Scherpen FJ, Meeuwsen-de Boer TG, Kamps WA, de Bont ES
Eur. J. Cancer, 2010-01-22;46(5):974-82.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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