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Human vWF-A1 (Research grade Caplacizumab Biosimilar) Antibody

Catalog #: MAB10591 Datasheet / COA / SDS
Recombinant Monoclonal Antibody
Catalog # Availability Size / Price Qty
MAB10591-100
MAB10591-SP
Detection of vWF-A1 in HUVECS cells by Flow Cytometry.
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Human vWF-A1 (Research grade Caplacizumab Biosimilar) Antibody Summary

Species Reactivity
Human
Specificity
VHH antibody detecting vWF-A1
Source
Monoclonal Llama Clone # Hu142
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. See Certificate of Analysis for details.
*Small pack size (-SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Intracellular Staining by Flow Cytometry
0.25 µg/106 cells
HUVEC Human umbilical vein endothelial cells

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Intracellular Staining by Flow Cytometry View Larger

Detection of vWF-A1 in HUVECS cells by Flow Cytometry. HUVECS cells treated with 5 ug/mL Brefeldin A for 5 hours were stained with Human vWF-A1 (RUO grade Caplacizumab Biosimilar) Antibody (Catalog # MAB10591, Filled histogram) or isotype control antibody Llama IgG (open histogram), followed by Goat anti Alpaca Rhodamine Red. To facilitate intracellular staining, cells were fixed with Flow Cytometry Fixation Buffer (FC004) and permeabilized with Flow Cytometry Permeabilization/Wash Buffer I (FC005). View our protocol for Staining Intracellular Molecules.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: vWF-A1

Caplacizumab is a humanized VHH immunoglobulin that binds to the A1 domain of the large von Willdebrand factor resulting in the inhibition of the interaction of glycoprotein GPIb-IX-V receptor on platelet surface.  The result of neutralizing of the von Willedebrand factor is reduced platelet aggregation.  Caplacizumab has been approved for the treatment of acute thrombotic thrombocytopenic purpura (aTTP), and has been shown to reduce the occurrence of thromboembolic events.

Long Name
von Willebrand Factor A1 Domain
Entrez Gene IDs
7450 (Human)
Alternate Names
vWFA1; vWF-A1

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