IBMX
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Description: PDE inhibitor (non-selective)
Chemical Name: 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
Purity: ≥98%
Biological Activity
IBMX is a phosphodiesterase inhibitor (IC50 values are 13, 18, 19, 32 and 50 μM for PDE4, PDE3, PDE1, PDE5 and PDE2 respectively). Suppresses α-adrenoceptor-mediated 5-HT release from neuroendocrine epithelial cells (IC50 = 1.3 μM). Facilitates differentiation of neural progenitor cells in vitro.Technical Data
M.Wt:
222.24
Formula:
C10H14N4O2
Solubility:
Soluble to 75 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
28822-58-4
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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cAMP promotes the differentiation of neural progenitor cells in vitro via modulation of voltage-gated calcium channels.
Lepski et al.
Front.Cell Neurosci., 2013;7:155 -
Phosphodiesterase inhibitors suppress α2-adrenoceptor-mediated 5-hydroxytryptamine release from tracheae of newborn rabbits.
Freitag et al.
Eur.J.Pharmacol., 1998;354:67
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Citations for IBMX
The citations listed below are publications that use Tocris products. Selected citations for IBMX include:
18 Citations: Showing 1 - 10
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Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons.
Authors: An Et al.
Elife 2019;8
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GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor.
Authors: Jewell Et al.
Elife 2019;8
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Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism.
Authors: Patra Et al.
Nat Cell Biol 2018;20:811
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Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane.
Authors: Burdyga Et al.
Proc Natl Acad Sci U S A. 2018;115(28):E6497
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Multiplexing PKA and ERK12 kinases FRET biosensors in living cells using single excitation wavelength dual colour FLIM.
Authors: Demeautis Et al.
Sci Rep 2017;7:41026
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Resveratrol enhances the inotropic effect but inhibits the proarrhythmic effect of sympathomimetic agents in rat myocardium.
Authors: Hernández-Cascales
PeerJ 2017;5:e3113
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Crystal structure of the GLP-1 receptor bound to a peptide agonist.
Authors: Jazayeri
Nature 2017;546:254
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Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory.
Authors: Havekes Et al.
J Neurosci 2016;36:8936
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Low-glucose enhances keratocyte-characteristic phenotype from corneal stromal cells in serum-free conditions.
Authors: Foster Et al.
Sci Rep 2015;5:10839
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Somatostatin and Ins mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP.
Authors: Elliott Et al.
Am J Physiol Endocrinol Metab 2015;308:E130
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MEK Inhibitors Reverse cAMP-Mediated Anxiety in Zebrafish.
Authors: Lundegaard Et al.
Chem Biol 2015;22:1335
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The interplay between cyclic AMP, MAPK, and NF-κB pathways in response to proinflammatory signals in microglia.
Authors: Ghosh Et al.
Eneuro 2015;2015:308461
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Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
Authors: Polito Et al.
PLoS One 2015;2
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Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor.
Authors: Cooke Et al.
Biomed Res Int 2015;172:593
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Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with isoprote.
Authors: Merino Et al.
Am J Physiol Lung Cell Mol Physiol 2015;10:e0132884
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Differentiation between human ClC-2 and CFTR Cl- channels with pharmacological agents.
Authors: Cuppoletti Et al.
Am J Physiol Cell Physiol 2014;307:C479
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Methadone but not mor. inhibits lubiprostone-stimulated Cl- currents in T84 intestinal cells and recombinant human ClC-2, but not CFTR Cl- currents.
Authors: Cuppoletti Et al.
Cell Biochem Biophys 2013;66:53
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DArgic modulation of ganglion-cell photoreceptors in rat.
Authors: Hook Et al.
Br J Pharmacol 2012;35:507
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