Ibudilast
Chemical Name: 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone
Purity: ≥99%
Biological Activity
Ibudilast is a phosphodiesterase inhibitor (IC50 values are 53, 35, 48, 12 and 10 μM for PDE Ia, II, III, IV and V respectively). Inhibits platelet aggregation and is an orally-active cerebral vasodilator, bronchodilator and antiallergic agent.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Ibudilast: a non-selective PDE inhibitor with multiple actions on blood cells and the vascular wall.
Kishi et al.
Cardiovasc.Drug Rev., 2001;19:215 -
Possible role of cyclic AMP phosphodiesterases in the actions of ibudilast on eosinophil thromboxane generation and airways smooth muscle tone.
Souness et al.
Br.J.Pharmacol., 1994;111:1081 -
KC-404: a potential anti-allergic agent with antagonistic action against slow reacting substance of anaphylaxis.
Nishino et al.
Jpn.J.Pharmacol., 1983;33:267
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