Home / Protein Ser/Thr Phosphatase Inhibitors / INCA-6

INCA-6

Catalog #: 2162
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2162/10
2162/50
INCA-6 | CAS No. 3519-82-2 | Protein Ser/Thr Phosphatase Inhibitors
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Description: Inhibitor of calcineurin-substrate association

Chemical Name: 9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione

Purity: ≥95%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

INCA-6 is an inhibitor of interaction between calcineurin and its substrate nuclear factor of activated T cells (NFAT); blocks at the substrate recognition site but not at the catalytic site (Kd = 0.8 mM). Inhibits NFAT dephosphorylation and nuclear import. Also prevents induction of cytokine mRNAs that are downstream targets of NFAT.

Technical Data

M.Wt:
284.31
Formula:
C20H12O2
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
3519-82-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Wnt7a Inhibits IL-1? Induced Catabolic Gene Expression and Prevents Articular Cartilage Damage in Experimental Osteoarthritis
    AL Gibson, CK Hui Mingal, AT Foote, T Uchimura, M Zhang, L Zeng
    Sci Rep, 2017;7(0):41823.
  2. Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules.
    Roehrl et al.
    Proc.Natl.Acad.Sci.USA, 2004;101:7554

Product Datasheets

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Citations for INCA-6

The citations listed below are publications that use Tocris products. Selected citations for INCA-6 include:

3 Citations: Showing 1 - 3

  1. NFAT isoforms play distinct roles in TNFα-induced retinal leukostasis.
    Authors: Bretz Et al.
    Exp Eye Res  2015;5:14963
  2. NFATc1 activity regulates the expression of myocilin induced by dexameth.
    Authors: Faralli Et al.
    Nat Chem Biol  2015;130:42614
  3. RNA-Seq reveals a role for NFAT-signaling in human retinal microvascular endothelial cells treated with TNFα.
    Authors: Savage Et al.
    PLoS One  2015;10:e0116941

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