Home / Chemokine Receptor Antagonists / INCB 3284 dimesylate

INCB 3284 dimesylate

Catalog #: 4306
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4306/10
4306/50
INCB 3284 dimesylate | CAS No. 887401-93-6 | Chemokine Receptor Antagonists
1 Image
Description: Selective CCR2 antagonist

Chemical Name: N-[2-[[(3R)-1-[trans-4-Hydroxy-4-(6-methoxy-3-pyridinyl)cyclohexyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-benzamide dimethanesulfonate

Purity: ≥98%

Product Details
Citations (3)
Supplemental Products
Reviews
Biological Activity Technical Data Product Datasheets Calculators

Biological Activity

INCB 3284 dimesylate is a potent, selective hCCR2 antagonist. Exhibits potent antagonism against monocyte chemoattractant molecule binding to hCCR2 and chemotaxis activity (IC50 values are 3.7 and 4.7 nM respectively). Also displays weak hERG activity; inhibits the hERG potassium current (IC50 = 84μ M). Orally bioavailable.

Technical Data

M.Wt:
712.76
Formula:
C26H31F3N4O4.2CH4O3S
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
887401-93-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for INCB 3284 dimesylate

The citations listed below are publications that use Tocris products. Selected citations for INCB 3284 dimesylate include:

3 Citations: Showing 1 - 3

  1. Cancer-associated fibroblasts promote hepatocellular carcinoma metastasis through chemokine-activated hedgehog and TGF-β pathways.
    Authors: Liu Et al.
    Cancer Lett.  2016;379:49
  2. Klotho gene deficiency causes salt-sensitive hypertension via monocyte chemotactic protein-1/CC chemokine receptor 2-mediated inflammation.
    Authors: Zhou Et al.
    Nat Commun  2015;26:121
  3. Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline.
    Authors: McMillin Et al.
    J Neuroinflammation  2014;11:121

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for INCB 3284 dimesylate

There are currently no reviews for this product. Be the first to review INCB 3284 dimesylate and earn rewards!

Have you used INCB 3284 dimesylate?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.