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INT 131

Catalog #: 7423 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7423/10
7423/50
INT 131 | CAS No. 315224-26-1 | PPAR gamma/NR1C3
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Description: PPARγ partial agonist

Chemical Name: 2,4-Dichloro-N-[3,5-dichloro-4-(3-quinolinyloxy)phenyl]benzenesulfonamide

Purity: ≥98%

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Biological Activity

INT 131 is a potent and selective PPARγ partial agonist (EC50 = 4 nM; Ki = 3.7 nM). It has a 20-fold higher affinity for PPARγ compared with that of Rosiglitazone (Cat. No. 5325). INT 131 improves glucose tolerance in a rodent model of diabetes without inducing hemodynamic and cardiovascular effects. Antidiabetic agent.

Technical Data

M.Wt:
514.21
Formula:
C21H12Cl4N2O3S
Solubility:
Soluble to 5 mM in DMSO and to 5 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
315224-26-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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