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Ipsapirone

Catalog #: 1869
2 Citations Datasheet / COA / SDS
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1869/10
1869/50
Ipsapirone | CAS No. 95847-70-4 | 5-HT1 Receptor Agonists
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Description: Selective 5-HT1A agonist
Alternative Names: TVX Q 7821

Chemical Name: 2-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3(2H)-one-1,1-dioxide

Purity: ≥99%

Product Details
Citations (2)
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Biological Activity

Ipsapirone is a selective 5-HT1A receptor agonist (Ki = 10 nM). Anxiolytic in vivo.

Technical Data

M.Wt:
401.48
Formula:
C19H23N5O3S
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
95847-70-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Central action of ipsapirone, a new anxiolytic drug, on serotoninergic, noradrenergic and DArgic functions.
    Maj et al.
    J.Neural.Transm., 1987;70:1
  2. Binding of the putative anxiolytic TVX Q 7821 to hippocampal 5-hydroxytryptamine (5-HT) recognition sites.
    Glaser and Traber
    Naunyn-Schmied.Arch.Pharmacol., 1985;329:211
  3. Brain serotonin receptors as a target for the putative anxiolytic TVX Q 7821.
    Traber et al.
    Brain Res.Bull., 1984;12:741

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Citations for Ipsapirone

The citations listed below are publications that use Tocris products. Selected citations for Ipsapirone include:

2 Citations: Showing 1 - 2

  1. Existence of Brain 5-HT1A-5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor-Receptor Interactions Regulating 5-HT1A Receptor Recognition.
    Authors: Borroto-Escuela Et al.
    ACS Omega  2017;2:4779
  2. Uncontrollable, but not controllable, stress desensitizes 5-HT1A receptors in the dorsal raphe nucleus.
    Authors: Rozeske Et al.
    J Neurosci  2011;31:14107

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