IRL-2500

Catalog #: 1838
1 Citation Datasheet / COA / SDS

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IRL-2500 | CAS No. 169545-27-1 | Endothelin ETB Receptor Antagonists

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Description: Potent ETB antagonist

Chemical Name: N-3-[1,1'-Biphenyl]-4-yl-N-(3,5-dimethylbenzoyl)-N-methyl-D-alanyl-L-tryptophan

Purity: ≥99%

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Product Details

Citations (1)

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Biological Activity

IRL-2500 is a potent endothelin receptor antagonist; shows some selectivity for ET_B receptors (IC₅₀ values are 1.3 and 94 nM for ET_B and ET_A receptors respectively). Inhibits ET_B receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo.

Technical Data

M.Wt:

573.69

Formula:

C₃₆H₃₅N₃O₄

Solubility:

Soluble to 75 mM in 1eq. NaOH with gentle warming

Purity:

≥99%

Storage:

Desiccate at RT

CAS No:

169545-27-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Characterization of a potent and selective endothelin-B receptor antagonist, IRL 2500.
Balwierczak et al.
J.Cardiovasc.Pharmacol., 1995;26:S393
Use of A-192621 and IRL-2500 to unmask the mesenteric and renal vasodilator role of endothelin ET_B receptors.
Leung et al.
J.Cardiovasc.Pharmacol., 2002;39:533
Effects of the ET_B-selective antagonist IRL 2500 in conscious spontaneously hypertensive and Wistar-Kyoto rats.
Webb et al.
J.Cardiovasc.Pharmacol., 1995;26:S389

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Citation for IRL-2500

The citations listed below are publications that use Tocris products. Selected citations for IRL-2500 include:

1 Citation: Showing 1 - 1

Intracrine endothelin signaling evokes IP3-dependent increases in nucleoplasmic Ca²⁺ in adult cardiac myocytes.
Authors: Merlen Et al.
J Mol Cell Cardiol 2013;62:189

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