IWP 4
Chemical Name: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
Purity: ≥98%
Biological Activity
IWP 4 is a potent inhibitor of Wnt/β-catenin signaling (IC50 = 25 nM). Has minimal effect on Notch and Hedgehog signaling pathways. Induces differentiation of cardiomyocytes from human ESCs and iPSCs.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling.
Lian et al.
Proc.Natl.Acad.Sci.U S A, 2012;109:E1848 -
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
Chen et al.
Nat.Chem.Biol., 2009;5:100 -
Differentiation of human epidermal neural crest stem cells (hEPI-NCSC) into virtually homogenous populations of DArgic neurons.
Narytnyk et al.
Stem Cell Rev., 2014;10:316 -
3D Printing of Personalized Thick and Perfusable Cardiac Patches and Hearts.
Noor et al.
Adv.Sci.(Weinh), 2019;6:1900344 -
Generation of spatial-patterned early-developing cardiac organoids using human pluripotent stem cells.
Hoang et al.
Nat.Protoc., 2018;13:723
Product Datasheets
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Citations for IWP 4
The citations listed below are publications that use Tocris products. Selected citations for IWP 4 include:
15 Citations: Showing 1 - 10
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Lipid droplet-associated lncRNA LIPTER preserves cardiac lipid metabolism.
Authors: Shiyong Et al.
Nat Cell Biol 2023;
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Engineering a living cardiac pump on a chip using high-precision fabrication.
Authors: Kamil Et al.
Sci Adv 2022;8:eabm3791
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Transcription factor protein interactomes reveal genetic determinants in heart disease.
Authors: Christine E Et al.
Cell 2022;185:794-814.e30
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Co-differentiation and Co-maturation of Human Cardio-pulmonary Progenitors and Micro-Tissues from Human Induced Pluripotent Stem Cells.
Authors: Wai Hoe Et al.
Bio Protoc 2022;12:e4488
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Recapitulating human cardio-pulmonary co-development using simultaneous multilineage differentiation of pluripotent stem cells.
Authors: Ming Et al.
Elife 2022;11
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SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway.
Authors: Andrew Et al.
J Virol 2021;95:e0086221
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Actinin BioID reveals sarcomere crosstalk with oxidative metabolism through interactions with IGF2BP2.
Authors: J Travis Et al.
Cell Rep 2021;36:109512
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Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment.
Authors: Paul Et al.
Cell Rep 2021;35:109088
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Replating Protocol for Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Authors: Esra Et al.
Methods Mol Biol 2021;2520:161-170
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Using hiPSC-CMs to Examine Mechanisms of Catecholaminergic Polymorphic Ventricular Tachycardia.
Authors: Parisa Et al.
Curr Protoc 2021;1:e320
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Poison Exon Splicing Regulates a Coordinated Network of SR Protein Expression during Differentiation and Tumorigenesis.
Authors: Joshy Et al.
Mol Cell 2020;80:648-665.e9
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Neural crest stem cells from human epidermis of aged donors maintain their multipotency in vitro and in vivo.
Authors: Boroujeni Et al.
Sci Rep 2019;9:9750
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Extracellular Matrix From Hypertrophic Myocardium Provokes Impaired Twitch Dynamics in Healthy Cardiomyocytes.
Authors: Sewanan Et al.
JACC Basic Transl Sci 2019;4:495
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Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions.
Authors: Jonathan G Et al.
Dev Cell 2018;44:87-96.e5
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iPSCs from a Hibernator Provide a Platform for Studying Cold Adaptation and Its Potential Medical Applications.
Authors: Wei Et al.
Cell 2018;173:851-863.e16
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