J 147
Chemical Name: 2,2,2-Trifluoroacetic acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide
Purity: ≥99%
Biological Activity
J 147 is a potent neuroprotective and neurotrophic compound. Protects against neurotoxicity in cortical neurons in vitro (EC50 = 25 - 200 nM). Reduces soluble Aβ40 and Aβ42 levels and increases BDNF levels in the hippocampus in vivo. Enhances memory in wild type rats. Prevents memory deficits and rescues cognitive deficits in young and aged transgenic Alzheimer's disease mice, respectively. Orally active.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease.
Chen et al.
PLoS One, 2011;6:e27865 -
The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice.
Prior et al.
Alzheimer's.Res.Ther., 2013;5:25 -
Metabolism of a potent neuroprotective hydrazide.
Chiruta et al.
Bioorg.Med.Chem., 2013;21:2733
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