Home / OX2 Receptor Antagonists / JNJ 10397049

JNJ 10397049

Catalog #: 4317
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4317/10
4317/50
JNJ 10397049 | CAS No. 708275-58-5 | OX2 Receptor Antagonists
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Description: Selective OX2 antagonist

Chemical Name: N-(2,4-Dibromophenyl)-N'-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]-urea

Purity: ≥99%

Product Details
Citations (2)
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Biological Activity

JNJ 10397049 is a selective OX2 receptor antagonist (pIC50 = 7.4 for chimeric OX2 receptors; pKB values are 5.9 and 8.5 for OX1 and OX2 receptors respectively). Shows no significant activity in a panel of over 50 other neurotransmitters and neuropeptide receptors. Achieves high level of OX2 receptor occupancy in the rat brain; exhibits sleep-promoting effects in rats.

Technical Data

M.Wt:
484.18
Formula:
C19H20Br2N2O3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
708275-58-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for JNJ 10397049

The citations listed below are publications that use Tocris products. Selected citations for JNJ 10397049 include:

2 Citations: Showing 1 - 2

  1. The arousal effect of hyperbaric oxygen through orexin/hypocretin an upregulation on ketamine/ethanol-induced unconsciousness in male rats.
    Authors: Lei Et al.
    J Neurosci Res  2020;98:201-211
  2. Promotion of Wakefulness and Energy Expenditure by Orexin-A in the Ventrolateral Preoptic Area.
    Authors: Mavanji Et al.
    Sleep  2015;38:1361

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