JP 1302 dihydrochloride
Chemical Name: N-[4-(4-Methyl-1-piperazinyl)phenyl]-9-acridinamine dihydrochloride
Purity: ≥99%
Biological Activity
JP 1302 dihydrochloride is an α2C-adrenoceptor antagonist that displays ~ 50-fold selectivity over other α2-adrenoceptor subtypes (Ki values are 28, 1470, 1700 and 3150 nM for human α2C, α2B, α2D and α2A subtypes respectively). Potently antagonizes adrenalin-stimulated 35GTPγS binding in vitro (KB = 16 nM) and produces antidepressant and antipsychotic-like effects in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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JP-1302: a new tool to shed light on the roles of α2C-adrenoceptors in brain.
Tricklebank
Br.J.Pharmacol., 2007;150:381 -
Pharmacological characterization and CNS effects of a novel highly selective α2C-adrenoceptor antagonist JP-1302.
Sallinen et al.
Br.J.Pharmacol., 2007;150:391
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Citation for JP 1302 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for JP 1302 dihydrochloride include:
1 Citation: Showing 1 - 1
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SKF83959 produces antidepressant effects in a chronic social defeat stress model of depression through BDNF-TrkB pathway.
Authors: Jiang Et al.
Mol Med Rep 2015;18
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