JQ1-FITC
Chemical Name: (S)-5-(3-(1-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-2-oxo-7,10,13-trioxa-3-azahexadecan-16-yl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid trifluoroacetate
Purity: ≥95%
Biological Activity
JQ1-FITC is a fluorescent BET bromodomain probe. It binds with high affinity to BRD4(BD1) and BRD4(BD2) (KD,app = 6.5 nM and 5.8 nM, respectively). Suitable for use in TR-FRET. Excitation and emission maxima (λ) are 495 nm and 525 nm, respectively.Optical Data for JQ1-FITC
| Emission Color | Green |
|---|---|
| λabs | 495 nm |
| λem | 525 nm |
| Extinction Coefficient (ε) | 7500 M-1cm-1 |
| Quantum Yield (φ) | 0.92 |
| Closest Laser line | 488 nm |
| Application | TR-FRET, Fluorescence polarization assays |
| Alternative For | FITC |
Plan Your Experiments
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Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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