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JT010

Catalog #: 6269
1 Citation Datasheet / COA / SDS
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6269/5
6269/25
JT010 | CAS No. 917562-33-5 | TRPA1 Activators
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Description: Potent and selective TRPA1 channel activator

Chemical Name: 2-Chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)acetamide

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

JT010 is a potent and selective TRPA1 channel activator (EC50 = 0.65 nM); activates the TRPA1 channel by covalently and site-selectively binding to Cys621. Exhibits selectivity for TRPA1 over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 channels (EC50 values are >1 μM).

Technical Data

M.Wt:
354.85
Formula:
C16H19ClN2O3S
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
917562-33-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A Potent and Site-Selective Agonist of TRPA1.
    Takaya J, Mio K, Shiraishi T et al.
    J. Am. Chem. Soc.

Product Datasheets

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Citation for JT010

The citations listed below are publications that use Tocris products. Selected citations for JT010 include:

1 Citation: Showing 1 - 1

  1. Derivation of nociceptive sensory neurons from hiPSCs with early patterning and temporally controlled NEUROG2 overexpression.
    Authors: Emmanouil Et al.
    Cell Rep Methods  2022;2:100341

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