KG 5

Catalog # Availability Size / Price Qty
5260/10
5260/50
KG 5 | CAS No. 877874-85-6 | Raf Kinase Inhibitors
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Description: PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor

Chemical Name: 2-(Methylthio)-6-[4-[5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]phenoxy]-4-pyrimidinamine

Purity: ≥98%

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Biological Activity

KG 5 is a PDGFRβ and B-Raf allosteric inhibitor. Also inhibits c-Raf, FLT3 and KIT. Disrupts blood vessel formation in zebrafish embryos and inhibits angiogenesis in a mouse angiogenesis model. Inhibits growth of renal and pancreatic tumors in mice. Also arrests cells in prometaphase. Orally available.

Technical Data

M.Wt:
459.45
Formula:
C20H16F3N7OS
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
877874-85-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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