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KHS 101 hydrochloride

Catalog #: 4888
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KHS 101 hydrochloride | CAS No. 1784282-12-7 | Compounds for Stem Cell Differentiation
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Description: Selective inducer of neuronal differentiation in hippocampal neural progenitors

Chemical Name: N4-(2-Methylpropyl)-N2-[(2-phenyl-4-thiazolyl)methyl]-2,4-pyrimidinediamine hydrochloride

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

KHS 101 hydrochloride is a selective inducer of neuronal differentiation; induces neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3 (EC50 ~1 μM). Suppresses astrocyte formation. Also induces acceleration of neuronal differentiation in the hippocampal dentate gyrus in vivo.

Technical Data

M.Wt:
375.92
Formula:
C18H21N5S.HCl
Solubility:
Soluble to 50 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1784282-12-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A small molecule accelerates neuronal differentiation in the adult rat.
    Wurdak et al.
    Proc.Natl.Acad.Sci.USA., 2010;107:16542

Product Datasheets

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Citation for KHS 101 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for KHS 101 hydrochloride include:

1 Citation: Showing 1 - 1

  1. Metabolic impairment of non-small cell lung cancers by mitochondrial HSPD1 targeting.
    Authors: Henrik Daa Et al.
    J Exp Clin Cancer Res  2021;40:248

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