L 012 sodium salt
Chemical Name: 8-Amino-5-chloro-2,3-dihydro-7-phenyl-pyrido[3,4-d]pyridazine sodium salt
Purity: ≥98%
Biological Activity
L 012 sodium salt is a luminal-based chemiluminescent probe. Detects NAPDH oxidase-derived reactive oxygen and nitrogen species (ROS and RNS). Active in vitro and in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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In vivo imaging of reactive oxygen and nitrogen species in inflammation using the luminescent probe L-012.
Kielland et al.
Free Radic.Biol.Med., 2009;47:760 -
Noninvasive assessment of localized inflammatory responses.
Zhou et al.
Free Radic.Biol.Med., 2012;52:218 -
Evaluation of lophine derivatives as L-012 (luminol analog)-dependent chemiluminescence enhancers for measuring horseradish peroxidase and H2 O2.
Ichibangase et al.
Luminescence., 2013;29:118
Product Datasheets
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Citations for L 012 sodium salt
The citations listed below are publications that use Tocris products. Selected citations for L 012 sodium salt include:
2 Citations: Showing 1 - 2
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Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis.
Authors: Mentrup Et al.
Nat.Commun. 2022;13:1880
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IL-33/ST2 induces neutrophil-dependent reactive oxygen species production and mediates gout pain.
Authors: Jie Et al.
Theranostics 2020;10:12189-12203
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