L-365,260
Chemical Name: N-[(3R)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(3-methylphenyl)urea
Purity: ≥99%
Biological Activity
L-365,260 is a selective cholecystokinin receptor 2 (CCK2) antagonist (IC50 values are 2 and 280 nM at CCK2 and CCK1 receptors respectively) that is inactive at a range of other receptors including opiate, muscarinic acetylcholine, α- and β adrenergic, histamine, angiotensin and bradykinin receptors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Benzodiazepine gastrin and brain cholecystokinin receptor ligands: L-365,260.
Kees et al.
J.Med.Chem., 1989;32:13 -
A new potent and selective non-peptide gastrin antagonist and brain cholecystokinin receptor (CCK-B) ligand: L-365,260.
Lotti and Chang
Eur.J.Pharmacol., 1989;162:273 -
Cholecystokinin action on layer 6b neurons in somatosensory cortex.
Chung et al.
Brain Res., 2009;1282:10
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