Home / Non-selective mGluR Agonists / L-Glutamic acid

L-Glutamic acid

Catalog #: 0218
9 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0218/1G
L-Glutamic acid | CAS No. 56-86-0 | Non-selective mGluR Agonists
1 Image
Description: Endogenous, non-selective glutamate receptor agonist

Chemical Name: (S)-1-Aminopropane-1,3-dicarboxylic acid

Product Details
Citations (9)
Supplemental Products
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

L-Glutamic acid is a the predominant excitatory transmitter in the mammalian central nervous system. L-Glutamic acid acts at ionotropic and metabotropic glutamate receptors.

MNI-caged-L-glutamate (Cat. No. 1490) also available.

Technical Data

M.Wt:
147.13
Formula:
C5H9NO4
Solubility:
Soluble to 100 mM in 1eq. NaOH
Storage:
Store at RT
CAS No:
56-86-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. The excitatory amino acid receptors: their classes, pharmacology and distinct properties in the function of the central nervous system.
    Monaghan et al.
    Annu.Rev.Pharmacol.Toxicol., 1989;29:365
  2. Excitatory amino acid transmitters.
    Watkins and Evans
    Annu.Rev.Pharmacol.Toxicol., 1981;21:165
  3. Ferroptosis: Death by lipid peroxidation.
    Yang and Stockwell et al.
    Trends Cell Biol., 2016;26:165

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for L-Glutamic acid

The citations listed below are publications that use Tocris products. Selected citations for L-Glutamic acid include:

9 Citations: Showing 1 - 9

  1. Multi-target action of �-alanine protects cerebellar tissue from ischemic damage.
    Authors: Kopach Et al.
    Cell Death Dis  2022;13:747
  2. Novel positive allosteric modulators of glutamate transport have neuroprotective properties in an in vitro excitotoxic model.
    Authors: Falcucci Et al.
    ACS Chem Neurosci  2019;10:3437
  3. Functional plasticity of GAT-3 in avian Müller cells is regulated by neurons via a glutamatergic input.
    Authors: Schitine Et al.
    J Neurosci  2015;82:42
  4. In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism.
    Authors: Owaisat Et al.
    Neurosci Lett  2012;525:12
  5. Glutamate carboxypeptidase II (GCPII) inhibitor displays anti-glutamate and anti-cocaine effects in an invertebrate assay.
    Authors: Tallarida Et al.
    Amino Acids  2012;42:2521
  6. Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A�mGlu2) receptor heteromerization and its psychoactive behavioral function.
    Authors: Moreno Et al.
    J Biol Chem  2012;287:44301
  7. Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT2A and mGlu2 receptors in the adult offspring.
    Authors: Moreno Et al.
    J Neurosci  2011;31:1863
  8. Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice.
    Authors: Galici Et al.
    J Pharmacol Exp Ther  2006;318:173
  9. Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons.
    Authors: Calò Et al.
    J Neurosci  2005;25:2245

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for L-Glutamic acid

There are currently no reviews for this product. Be the first to review L-Glutamic acid and earn rewards!

Have you used L-Glutamic acid?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.