L-(-)-threo-3-Hydroxyaspartic acid
Purity: ≥98%
Biological Activity
L-(-)-threo-3-Hydroxyaspartic acid is a potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor. In [3H]-d-Asp uptake assays in HEK293 cells expressing human EAAT1, EAAT2 and EAAT3, Ki values are 11, 19, and 14 μM, respectively. In a FLIPR Membrane Potential (FMP) assay, Km values are 3.6, 3.8 and 3.2 μM for human EAAT1, EAAT2 and EAAT3, respectively.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Potentiation of L-glutamate and L-aspartate excitation of cat spinal neurones by the stereoisomers of threo-3-hydroxyaspartate.
Johnston et al.
J.Neurochem., 1980;34:241 -
Neurotoxicity of L-glutamate and DL-threo-3-hydroxyaspartate in the rat striatum.
McBean and Roberts
J.Neurochem., 1985;44:247 -
(2S,3S,4R)-2-(Carboxycyclopropyl)glycine, a potent and competitive inhibitor of both glial and neuronal uptake of glutamate.
Nakamura et al.
Neuropharmacology, 1993;32:833 -
Pharmacological characterization of human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 in a fluorescence-based membrane potential assay.
Jensen and Bräuner-Osborne et al.
Biochem.Pharmacol., 2004;67:2115
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Citation for L-(-)-threo-3-Hydroxyaspartic acid
The citations listed below are publications that use Tocris products. Selected citations for L-(-)-threo-3-Hydroxyaspartic acid include:
1 Citation: Showing 1 - 1
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Gut microbiota-derived D-serine protects against acute kidney injury.
Authors: Nakade Et al.
JCI Insight 2018;3
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