[Leu31,Pro34]-Neuropeptide Y (human, rat)
![[Leu31,Pro34]-Neuropeptide Y (human, rat)](https://resources.rndsystems.com/images/datasheets/structures/leu31-pro34-neuropeptide-y-human-rat_1176.png "[Leu31,Pro34]-Neuropeptide Y (human, rat)")
Purity: ≥95%
Biological Activity
[Leu31,Pro34]-Neuropeptide Y (human, rat) is a high affinity neuropeptide Y Y1 receptor agonist (Ki = 0.39 nM). Also shows affinity for Y4 and Y5 receptors.Technical Data
(Modifications: Tyr-36 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.
Bard et al.
J.Biol.Chem., 1995;270:26762 -
[Leu31, Pro34]Neuropeptide Y: a specific Y1 receptor agonist.
Fuhlendorff et al.
Proc.Natl.Acad.Sci.U.S.A., 1990;87:182 -
Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y1-selective antagonist BIBP3226.
Kask et al.
Br.J.Pharmacol., 1998;124:1507 -
XVI.International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors.
Michel et al.
Pharmacol.Rev., 1998;50:143
Product Datasheets
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Citations for [Leu31,Pro34]-Neuropeptide Y (human, rat)
The citations listed below are publications that use Tocris products. Selected citations for [Leu31,Pro34]-Neuropeptide Y (human, rat) include:
3 Citations: Showing 1 - 3
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Neuropeptide Y and cannabinoids interaction in the amygdala after exposure to shock and reminders model of PTSD.
Authors: Maymon Et al.
Neuropharmacology 2019;162
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Spinal activation of the NPY Y1 receptor reduces mechanical and cold allodynia in rats with chronic constriction injury.
Authors: Malet
Peptides 2017;92:38
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Neuropeptide Y1 Receptor Regulates Glucocorticoid-Induced Inhibition of Osteoblast Differentiation in Murine MC3T3-E1 Cells via ERK Signaling.
Authors: Yu Et al.
Int J Mol Sci 2016;17
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