Home / DNA, RNA and Protein Synthesis Inhibitors / Lin28 1632

Lin28 1632

Catalog #: 6068
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6068/10
6068/50
Lin28 1632 | CAS No. 108825-65-6 | DNA, RNA and Protein Synthesis Inhibitors
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Description: RNA binding protein Lin28 inhibitor; promotes mESC differentiation; also bromodomain inhibitor

Chemical Name: N-Methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Lin28 1632 is an RNA binding protein Lin28 inhibitor (IC50 = 8 μM). Lin28 1632 blocks binding of Lin28 to let-7 pre-micro RNA. Lin28 1632 inhibits stemness and induces differentiation of murine ESCs. Lin28 1632 increases let-7 miRNA and suppresses PD-L1 expression in multiple human cancer cell lines. Lin28 1632 inhibits growth of tumor cell lines and tumor-sphere formation in vitro. Lin28 1632 also inhibits growth of tumor xenografts in mice by enhancing T cell-mediated antitumor immunity. Lin28 1632 is also bromodomain inhibitor. Lin28 1632 inhibits tumor growth and metastasis in vivo in immunodeficient orthotopic mouse models of human breast cancer cell MDA-MB-231.

Technical Data

M.Wt:
281.31
Formula:
C15H15N5O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
108825-65-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A small-molecule inhibitor of Lin28.
    Roos et al.
    ACS Chem.Biol., 2016;11:2773
  2. LIN28/ let-7/PD-L1 pathway as a target for cancer immunotherapy.
    Chen et al.
    Cancer Immunol.Res., 2019;7:487

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Citations for Lin28 1632

The citations listed below are publications that use Tocris products. Selected citations for Lin28 1632 include:

3 Citations: Showing 1 - 3

  1. Lin28A/let-7 oncogenic circuit is a potential therapeutic target in neurocutaneous melanosis-associated CNS tumors in children.
    Authors: Yoji Et al.
    Neurooncol Adv  2021;3:vdaa174
  2. Functional Characterization of the Lin28/let-7 Circuit During Forelimb Regeneration in Ambystoma mexicanum and Its Influence on Metabolic Reprogramming.
    Authors: Alfredo Et al.
    Front Cell Dev Biol  2020;8:562940
  3. LIN28B Underlies the Pathogenesis of a Subclass of Ewing Sarcoma LIN28B Control of EWS-FLI1 Stability.
    Authors: Miguel N Et al.
    Cell Rep  2020;30:4567-4583.e5

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