Liraglutide
Purity: ≥95%
Biological Activity
Liraglutide is a highly potent, long-acting GLP-1 receptor agonist (EC50 = 61 pM). Acylated derivative of GLP-1 (7-37) (Cat. No. 5374). Inhibits food and water intake, causing lasting and reversible weight loss in normal and obese rats. In an animal model of Alzheimer's disease, Liraglutide decreases levels of Aβ and soluble amyloid, and reduces neuroinflammation.Technical Data
(Modifications: Lys-20 = Lys-(γ-Glu-palmitoyl))
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration.
Knudsen et al.
J.Med.Chem., 2000;43:1664 -
Systemic administration of the long-acting GLP-1 derivative NN2211 induces lasting and reversible weight loss in both normal and obese rats.
Larsen et al.
Diabetes, 2001;50:2530
Product Datasheets
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Citations for Liraglutide
The citations listed below are publications that use Tocris products. Selected citations for Liraglutide include:
2 Citations: Showing 1 - 2
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Osmoadaptive GLP-1R signalling in hypothalamic neurones inhibits antidiuretic hormone synthesis and release.
Authors: David Et al.
Mol Metab 2023;70:101692
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Liraglutide Counteracts Endoplasmic Reticulum Stress in Palmitate-Treated Hypothalamic Neurons without Restoring Mitochondrial Homeostasis.
Authors: Steven W Et al.
Int J Mol Sci 2022;24
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