LW 6
Chemical Name: Methyl 4-hydroxy-3-[[2-(4-tricyclo[3.3.1.13,7]dec-1-ylphenoxy)acetyl]amino]benzoate
Purity: ≥98%
Biological Activity
LW 6 is a malate dehydrogenase-2 (MDH2) inhibitor (IC50 = 6.3 μM). Also inhibits HIF-1α. Prevents accumulation of HIF-1α in Hep3B cells under hypoxic conditions (IC50 = 2.6 μM) with resulting decrease in expression of HIF-1α target genes VEGF and EPO. Inhibits proliferation of activated human T cells ex vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Malate dehydrogenase-2 inhibitor LW6 promotes metabolic adaptations and reduces proliferation and apoptosis in activated human T-cells.
Eleftheriadis et al.
Exp.Ther.Med., 2015;5:1959 -
(Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors.
Lee et al.
J.Med.Chem., 2007;50:1675 -
A novel malate dehydrogenase 2 inhibitor suppresses hypoxia-inducible factor-1 by regulating mitochondrial respiration.
Ban et al.
PLoS One, 2016;9:e0162568
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