MB 05032
Chemical Name: P-[5-[2-Amino-5-(2-methylpropyl)-4-thiazolyl]-2-furanyl]phosphonic acid
Purity: ≥98%
Biological Activity
MB 05032 is a potent FBPase inhibitor (EC50 values are 1.6, 29 and 61 nM for human liver FBPase, human muscle FBPase and rat liver FBPase). Promotes hematopoietic stem cell and progenitor cell expansion. Increases engraftment in primary NSG mice recipients. Also enhances myeloid and lymphoid chimerism in secondary NSG mouse recipients. Promotes glycolysis, glucose uptake and lactate production in umbilical cord blood CD34+ cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis.
Guo et al.
Nat.Med., 2018;24:360 -
Fructose-1, 6-bisphosphatase inhibitors for reducing excessive endogenous glucose production in type 2 diabetes.
van Poelje et al.
Handb.Exp.Pharmacol., 2011;203:279
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