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Mepyramine maleate

Catalog #: 0660
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0660/100
Mepyramine maleate | CAS No. 59-33-6 | Histamine H1 Inverse Agonists
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Description: Selective H1 inverse agonist
Alternative Names: Pyrilamine maleate

Chemical Name: 2-((2-(Dimethylamino)ethyl)(p-methoxybenzyl)amino)-pyridine maleate

Product Details
Citations (5)
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Biological Activity

Mepyramine maleate is a selective inverse agonist for the H1 receptor. Inhibits histamine induced inositol phosphate (InsP) production (log EC50 = -7.94) and intracellular calcium mobilization. Sequesters Gq/11 protein, reducing its availability for other receptors associated with the same signaling pathway.

Technical Data

M.Wt:
401.46
Formula:
C17H23N3O.C4H4O4
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Storage:
Store at RT
CAS No:
59-33-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Mepyramine maleate

The citations listed below are publications that use Tocris products. Selected citations for Mepyramine maleate include:

5 Citations: Showing 1 - 5

  1. A split luciferase-based probe for quantitative proximal determination of Gαq signalling in live cells.
    Authors: Littmann Et al.
    Sci Rep  2018;8:17179
  2. Involvement of H1 and H2 receptors and soluble guanylate cyclase in histamine-induced relaxation of rat mesenteric collecting lymphatics.
    Authors: Kurtz Et al.
    Microcirculation  2014;21:593
  3. The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS.
    Authors: Connelly Et al.
    Br J Pharmacol  2009;157:55
  4. Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: involvement of the H2 receptor and cAMP.
    Authors: Flamand Et al.
    Br J Pharmacol  2004;141:552
  5. Mast cells are required for experimental oral allergen-induced diarrhea.
    Authors: Brandt Et al.
    J Clin Invest  2003;112:1666

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