Milrinone
Chemical Name: 1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile
Purity: ≥98%
Biological Activity
Milrinone is a potent cAMP phosphodiesterase inhibitor (IC50 = 56 nM for inhibition of PDE III). Has inotropic and vasodilator effects following oral or intravenous administration in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Characterization of the cardiotonic effects of milrinone, a new and potent cardiac bipyridine, on isolated tissues from several animal species.
Alousi et al.
J.Cardiovasc.Pharmacol., 1983;5:804 -
The presence of five cyclic nucleotide phosphodiesterase isoenzyme activities in bovine tracheal smooth muscle and the functional effects of selective inhibitors.
Shahid et al.
Br.J.Pharmacol., 1991;104:471 -
Photoaffinity labelling of cyclic GMP-inhibited phosphodiesterase (PDE III) in human and rat platelets and rat tissues: effects of phosphodiesterase inhibitors.
Tang et al.
Eur.J.Pharmacol., 1994;268:105
Product Datasheets
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Citations for Milrinone
The citations listed below are publications that use Tocris products. Selected citations for Milrinone include:
2 Citations: Showing 1 - 2
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The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium.
Authors: Ørstavik Et al.
Dent Res J (Isfahan) 2015;10:e0115547
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Thrombospondin-1 induces platelet activation through CD36-dependent inhibition of the cAMP/protein kinase A signaling cascade.
Authors: Roberts Et al.
Blood 2010;116:4297
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