Minocycline hydrochloride

Biological Activity

Minocycline hydrochloride is a tetracycline antibiotic. Displays neuroprotective, antiapoptotic, anti-inflammatory and antimicrobial effects. Acts as a matrix metalloproteinase (MMP) inhibitor; attenuates disease severity in mouse models of multiple sclerosis. Orally active and brain penetrant. Allows formation of extended pluripotent stem (EPS) cells in combination with CHIR 99021 (Cat.No. 4423), (S)-(+)-Dimethindene maleate (Cat.No. 1425) and human leukemia inhibitory factor.

For more information about how Minocycline hydrochloride may be used, see our protocol: Generation and Propagation of EPS cells (LCDM Cocktail).

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Derivation of pluripotent stem cells with in vivo embryonic and extraembryonic potency.
   Yang et al.
   Cell., 2017;169:243
2. Targeting leukocyte MMPs and transmigration: MinCyc as a potential therapy for multiple sclerosis.
   Brundula et al.
   Brain, 2002;125:1297
3. MinCyc prevents the development of neuropathic pain, but not acute pain: possible anti-inflammatory and antioxidant mechanisms.
   Padi and Kulkarni
   Eur.J.Pharmacol., 2008;601:79
4. MinCyc, a tetracy. derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia.
   Tikka et al.
   J.Neurosci., 2001;21:2580

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