Home / Nicotinic Acid Receptor (GPR109) Agonists / MK 1903

MK 1903

Catalog #: 4622
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4622/10
MK 1903 | CAS No. 1268882-43-4 | Nicotinic Acid Receptor (GPR109) Agonists
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Description: Potent and selective GPR109A (HCA2) agonist

Chemical Name: (4aR,5aR)-4,4a,5,5a-Tetrahydro-1H-cyclopropa[4,5]cyclopenta[1,2]pyrazole-3-carboxylic acid

Purity: ≥98%

Product Details
Citations (4)
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Biological Activity

MK 1903 is a potent and selective hydroxycarboxylic acid receptor 2 (HCA2, GPR109A) full agonist; exhibits greater potency than niacin in a whole cell HTRF-cAMP assay (EC50 values are 12.9 and 51 nM respectively). Exhibits no binding at the GRP109B receptor.

Technical Data

M.Wt:
164.16
Formula:
C8H8N2O2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1268882-43-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for MK 1903

The citations listed below are publications that use Tocris products. Selected citations for MK 1903 include:

4 Citations: Showing 1 - 4

  1. Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy.
    Authors: Elisabetta Et al.
    EMBO Mol Med  2023;15:e16225
  2. Potential role of the hydroxyl carboxylic acid receptor type 2 (HCAR2) in microglia pathophysiology: A possible cross-talk with C-X-C chemokine receptor 1 (CXCR1)
    Authors: Perrone Et al.
    Neuropharmacology  2023;
  3. Identification of the novel role of butyrate as AhR ligand in human intestinal epithelial cells
    Authors: Marinelli Et al.
    Sci.Rep.  2019;9:643
  4. Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells.
    Authors: Martin-Gallausiaux Et al.
    Front Immunol  2019;9:2838

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