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ML 299

Catalog #: 4894 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4894/2
ML 299 | CAS No. 1426916-00-8 | Phospholipase Inhibitors
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Description: Potent inhibitor of PLD1 and PLD2; CNS penetrant

Chemical Name: 4-Bromo-N-[(1S)-2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]-1-methylethyl]benzamide

Purity: ≥98%

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Biological Activity

ML 299 is a selective allosteric modulator and potent inhibitor of phospholipases D1 and D2 (IC50 values are 6 and 12 nM, respectively). ML 299 decreases invasive migration in glioblastoma cells and increases caspase 3/7 activity in serum-free conditions. ML 299 is non-cytotoxic, active in vivo and CNS penetrant.

Technical Data

M.Wt:
489.39
Formula:
C23H26BrFN4O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1426916-00-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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