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ML 334

Catalog #: 5625
1 Citation Datasheet / COA / SDS
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5625/5
ML 334 | CAS No. 1432500-66-7 | Nrf2 Activators
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Description: Inhibitor of Keap1- Nrf2 interaction
Alternative Names: LH601A

Chemical Name: (1S,2R)-2-[[(1S)-1-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-3,4-dihydro-2(1H)-isoquinolinyl]carbonyl]cyclohexanecarboxylic acid

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

ML 334 is an Nrf2 activator; inhibits Nrf2/Keap1 interaction (Kd = 1 μM). Promotes Nrf2 nuclear translocation and induces antioxidant response element (ARE) activity in vitro. Cell permeable.

Technical Data

M.Wt:
446.5
Formula:
C26H26N2O5
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1432500-66-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for ML 334

The citations listed below are publications that use Tocris products. Selected citations for ML 334 include:

1 Citation: Showing 1 - 1

  1. A novel role of KEAP1/PGAM5 complex: ROS sensor for inducing mitophagy.
    Authors: Vladimir Et al.
    Redox Biol  2021;48:102186

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