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ML 385

Catalog #: 6243
2 Citations 1 Review Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6243/5
6243/25
ML 385 | CAS No. 846557-71-9 | Nrf2 Inhibitors
1 Image
Description: Nrf2 inhibitor; phenotypically lethal

Chemical Name: N-[4-[2,3-Dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide

Purity: ≥98%

Product Details
Citations (2)
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

ML 385 is an Nrf2 inhibitor. Blocks Nrf2 downstream target gene expression. Enhances cytotoxic effects of doxorubicin (Cat. No. 2252) or Taxol (Cat. No. 1097) in non-small cell lung cancer (NSCLC). Demonstrates selectivity for NSCLC cells with KEAP1 mutations.

Technical Data

M.Wt:
511.59
Formula:
C29H25N3O4S
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
846557-71-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for ML 385

The citations listed below are publications that use Tocris products. Selected citations for ML 385 include:

2 Citations: Showing 1 - 2

  1. Identifying new biomarkers of aggressive Group 3 and SHH medulloblastoma using 3D hydrogel models, single cell RNA sequencing and 3D OrbiSIMS imaging.
    Authors: Steven C Et al.
    Acta Neuropathol Commun  2023;11:6
  2. Capsosiphon fulvescens Glycoproteins Enhance Probiotics-Induced Cognitive Improvement in Aged Rats.
    Authors: Jeong Hwan Et al.
    Nutrients  2020;12

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Inhibition of nrf2 in mouse macrophages
By Anonymous on 09/24/2019
Species: Mouse

Used to inhibit nrf2

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