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ML 9 hydrochloride

Catalog #: 0431
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0431/10
ML 9 hydrochloride | CAS No. 105637-50-1 | Myosin Light Chain Kinase Inhibitors
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Description: Myosin light chain kinase inhibitor

Chemical Name: 1-(5-Chloronaphthalenesulfonyl)homopiperazine hydrochloride

Purity: ≥98%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

ML 9 hydrochloride is a selective MLCK inhibitor (Ki values are 4, 32 and 54 μM for MLCK, PKA and PKC respectively). Also inhibits STIM1-plasma membrane interactions, preventing store-operated Ca2+ entry (SOCE).

Technical Data

M.Wt:
361.29
Formula:
C15H17ClN2O2S.HCl
Solubility:
Soluble to 25 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
105637-50-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. STIM and Orai: the long-awaited constituents of store-operated calcium entry.
    Varnai et al.
    TiPS, 2009;30:118
  3. Pharmacology of protein kinase inhibitors.
    Hidaka and Koybashi
    Annu.Rev.Pharmacol.Toxicol., 1992;32:377
  4. Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle.
    Seto et al.
    Eur.J.Pharmacol., 1991;195:267
  5. Pharmacology of the isoquinoline sulfonamide protein kinase C inhibitors.
    Hidaka and Hagiwara
    Trends Pharmacol.Sci., 1987;8:162

Product Datasheets

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Citations for ML 9 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for ML 9 hydrochloride include:

4 Citations: Showing 1 - 4

  1. Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling.
    Authors: Dobson Et al.
    J Pharmacol Exp Ther  2015;10:e0125974
  2. Age-dependent contribution of Rho kinase in CB-induced contraction of human detrusor smooth muscle in vitro.
    Authors: Kirschstein Et al.
    Acta Pharmacol Sin  2014;35:74
  3. An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling.
    Authors: Siddoway Et al.
    PLoS One  2013;33:11206
  4. Differential roles for STIM1 and STIM2 in store-operated calcium entry in rat neurons.
    Authors: Gruszczynska-Biegala Et al.
    PLoS One  2011;6:e19285

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