Mouse CCR6 APC-conjugated Antibody

Catalog #: FAB590A
3 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
FAB590A-025
FAB590A-100

Detection of CCR6 in Mouse Splenocytes by Flow Cytometry.

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Citations (3)

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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Mouse CCR6 APC-conjugated Antibody Summary

Species Reactivity

Mouse

Specificity

Detects mouse CCR6-transfected rat RBL cells but not the parent cell line or cells transfected with mouse CCR5.

Source

Monoclonal Rat IgG_2A Clone # 140706

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

RBL-1 rat basophilic leukemia cell line transfected with mouse CCR6
Met1-Met367
Accession # O54689

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Label

Allophycocyanin (Excitation= 620-650 nm, Emission= 660-670 nm)

Applications

Recommended Concentration

Sample

Flow Cytometry

10 µL/10⁶ cells

See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry

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Detection of CCR6 in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes were stained with (A) Rat Anti-Mouse CCR6 APC-conjugated Monoclonal Antibody (Catalog # FAB590A) or (B) Rat IgG2A control antibody (Catalog # IC006A).and Rat Anti-Mouse B220/CD45R Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB1217F). View our protocol for Staining Membrane-associated Proteins.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze.

12 months from date of receipt, 2 to 8 °C as supplied.

Background: CCR6

CCR6 is a seven transmembrane-spanning G protein-coupled receptor that binds the chemokine MIP-3 alpha and mediates the chemoattraction of B and T lymphocytes.

Entrez Gene IDs

1235 (Human); 12458 (Mouse); 308163 (Rat)

Alternate Names

BN-1; CC-CKR-6; CCR6; CCR-6; CD196 antigen; CD196; chemokine (C-C motif) receptor 6; CKRL3; CKR-L3; CKR-L3G-protein coupled receptor 29; CKRL3LARC receptor; CMKBR6; CMKBR6STRL22; DRY6; GPR29; GPR29C-C CKR-6; GPRCY4; GPR-CY4; GPRCY4DRY-6; lymphocyte, 22; STRL22

Product Datasheets

Product Datasheet

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Related Research Areas

Citations for Mouse CCR6 APC-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

3 Citations: Showing 1 - 3
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Essential role for CCR6 in certain inflammatory diseases demonstrated using specific antagonist and knockin mice
Authors: R Robert, C Ang, G Sun, L Juglair, EX Lim, LJ Mason, NL Payne, CC Bernard, CR Mackay
JCI Insight, 2017-08-03;2(15):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry
Respiratory Syncytial virus infection compromises asthma tolerance by recruiting interleukin-17A-producing cells via CCR6-CCL20 signaling
Authors: T Shi, Y He, W Sun, Y Wu, L Li, Z Jie, X Su
Mol. Immunol., 2017-06-07;88(0):45-57.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry
CCR6 is required for epidermal trafficking of gammadelta-T cells in an IL-23-induced model of psoriasiform dermatitis.
Authors: Mabuchi T, Singh T, Takekoshi T, Jia G, Wu X, Kao M, Weiss I, Farber J, Hwang S
J Invest Dermatol, 2012-08-16;133(1):164-71.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry