Mouse IL-11 Antibody Summary
Gly23-Leu199
Accession # P47873
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Cell Proliferation Induced by IL‑11 and Neutralization by Mouse IL‑11 Antibody. Recombinant Mouse IL‑11 (Catalog # 418-ML) stimulates proliferation in the T11 mouse plasmacytoma cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Mouse IL‑11 (0.75 ng/mL) is neutralized (green line) by increasing concentrations of Rat Anti-Mouse IL‑11 Monoclonal Antibody (Catalog # MAB418). The ND50 is typically 0.5-2.0 µg/mL.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: IL-11
Interleukin-11 is a pleiotropic cytokine that was originally detected in the conditioned medium of an IL-1 alpha -stimulated primate bone marrow stromal cell line (PU-34) as a mitogen for the IL-6-responsive murine plasmacytoma cell line T1165. IL-11 was also independently discovered as an adipogenesis inhibitory factor (AGIF). The mouse IL-11 cDNA encodes a 199 amino acid precursor polypeptide with a 22 amino acid hydrophobic signal that is processed proteolytically to generate the 177 amino acid mature protein. IL-11 contains no cysteine residues or potential glycosylation sites. IL-11 has multiple effects on both hematopoietic and nonhematopoietic cells. Many of the biological effects described for IL-11 overlap those for IL-6. In vitro, IL-11 can synergize with IL-3, IL-4 and SCF to shorten the G0 period of early hematopoietic progenitors. IL-11 also enhances the IL-3-dependent megakaryocyte colony formation. IL-11 has been found to stimulate the T cell dependent development of specific immunoglobulin-secreting B cells. IL-11, in the presence of IL-3 or SCF, has also been shown to stimulate erythropoiesis. Among nonhematopoietic cell populations, IL-11, like IL-6 and LIF, can stimulate the synthesis of hepatic acute‑phase proteins. Consistent with the in vitro functions of IL‑11, in vivo administration of human IL-11 in normal mice was found to enhance the generation of Ig producing cells and platelets, and to increase the cycling rates of bone marrow-derived CFU-GM, BFU-E, and CFU-GEMM progenitors. IL-11 exerts its biological activities through binding to a specific high-affinity receptor complex consisting of an IL-11 receptor alpha chain and gp130.
Product Datasheets
Citations for Mouse IL-11 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 3
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IL-11 Induces Encephalitogenic Th17 Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis
Authors: X Zhang, N Kiapour, S Kapoor, T Khan, M Thamilaras, Y Tao, S Cohen, R Miller, RA Sobel, S Markovic-P
J. Immunol., 2019-07-24;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
IL-11 is required for A1 adenosine receptor-mediated protection against ischemic AKI.
Authors: Kim J, Kim M, Ham A, Brown K, Greene R, D'Agati V, Lee H
J Am Soc Nephrol, 2013-06-27;24(10):1558-70.
Species: Mouse
Sample Types: In Vivo, Whole Tissue
Applications: IHC, Neutralization -
Cold pre-conditioning neuroprotection depends on TNF-alpha and is enhanced by blockade of interleukin-11.
Authors: Mitchell HM, White DM, Domowicz MS, Kraig RP
J. Neurochem., 2010-12-01;117(2):187-96.
Species: Rat
Sample Types: Whole Tissue
Applications: Neutralization
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