Mouse Integrin alpha 3/CD49c Antibody

Name: Mouse Integrin alpha 3/CD49c Antibody
Brand: R&D Systems
SKU: AF2787
Rating: 4 (1 reviews)

Catalog #: AF2787
6 Citations 1 Review Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
AF2787
AF2787-SP

All Integrin alpha 3/CD49c Antibodies

Product Details

Citations (6)

FAQs

Supplemental Products

Reviews (1)

Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Mouse Integrin alpha 3/CD49c Antibody Summary

Species Reactivity

Mouse

Specificity

Detects mouse Integrin alpha 3/CD49c in direct ELISAs and Western blots. In direct ELISAs, less than 10% cross-reactivity with recombinant human (rh) Integrin alpha 3 is observed.

Source

Polyclonal Goat IgG

Purification

Antigen Affinity-purified

Immunogen

S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse Integrin alpha 3/CD49c
Phe33-Glu993
Accession # Q62470

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Label

Unconjugated

Applications

Recommended Concentration

Sample

Western Blot

0.1 µg/mL

Recombinant Mouse Integrin alpha 3/CD49c

Flow Cytometry

0.25 µg/10⁶ cells

XB2 mouse teratoma keratinocyte cell line

CyTOF-ready

Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Integrin alpha 3/CD49c

Integrin alpha 3, also known as CD49c and VLA-3 alpha, is a type I membrane protein that heterodimerizes with Integrin beta 1. alpha 3 beta 1 is a cell surface adhesion molecule that functions as a receptor for laminin, fibronectin, collagen, epiligrin, thrombospondin and chondroitin sulfate proteoglycan 4. The extracellular domain of human and mouse Integrin alpha 3 share approximately 87% amino acid sequence homology.

Entrez Gene IDs

3675 (Human); 16400 (Mouse)

Alternate Names

antigen identified by monoclonal J143; CD49 antigen-like family member C; CD49c antigen; CD49c; FLJ34631; FLJ34704; FRP-2; Galactoprotein B3; GAP-B3; GAPB3CD49C; Integrin alpha 3; integrin alpha-3; integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor); ITGA3; MSK18; VCA-2; very late activation protein 3 receptor, alpha-3 subunit; VL3A; VLA-3 subunit alpha; VLA3a

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

Citations for Mouse Integrin alpha 3/CD49c Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

6 Citations: Showing 1 - 6
Filter your results:

Filter by:

Activated Protein C Attenuates Severe Inflammation by Targeting VLA-3(high) Neutrophil Subpopulation in Mice
Authors: PP Sarangi, HW Lee, YV Lerman, A Trzeciak, EJ Harrower, AR Rezaie, M Kim
J. Immunol., 2017-09-06;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry
Integrin alpha6 maintains the structural integrity of the kidney collecting system
Authors: Olga M Viquez
Matrix Biol, 2016-12-30;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot
Signaling events mediated by alpha3beta1 integrin are essential for mammary tumorigenesis.
Authors: Cagnet S, Faraldo M, Kreft M, Sonnenberg A, Raymond K, Glukhova M
Oncogene, 2013-09-30;33(34):4286-95.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot
Strain-induced differentiation of fetal type II epithelial cells is mediated via the integrin alpha6beta1-ADAM17/tumor necrosis factor-alpha-converting enzyme (TACE) signaling pathway.
Authors: Wang Y, Huang Z, Nayak P, Matthews B, Warburton D, Shi W, Sanchez-Esteban J
J Biol Chem, 2013-07-25;288(35):25646-57.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization
Gain of glycosylation in integrin alpha3 causes lung disease and nephrotic syndrome.
Authors: Nicolaou N, Margadant C, Kevelam S, Lilien M, Oosterveld M, Kreft M, van Eerde A, Pfundt R, Terhal P, van der Zwaag B, Nikkels P, Sachs N, Goldschmeding R, Knoers N, Renkema K, Sonnenberg A
J Clin Invest, 2012-11-01;122(12):4375-87.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot
Integrin alpha3beta1 inhibits directional migration and wound re-epithelialization in the skin.
Authors: Margadant C, Raymond K, Kreft M, Sachs N, Janssen H, Sonnenberg A
J. Cell. Sci., 2009-01-15;122(0):278-88.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot