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Mouse LYVE-1 Antibody

Catalog #: AF2125
75 Citations 3 Reviews Datasheet / COA / SDS
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AF2125
AF2125-SP
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LYVE‑1 in Mouse Liver.
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Citations (75)
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Reviews (3)
Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Mouse LYVE-1 Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse LYVE-1 in direct ELISAs and Western blots.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse LYVE-1
Ala24-Thr234
Accession # Q8BHC0
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Endotoxin Level
<0.10 EU per 1 μg of the antibody by the LAL method.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
0.25 µg/mL
See below
Immunohistochemistry
5-15 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunohistochemistry LYVE‑1 antibody in Mouse Liver by Immunohistochemistry (IHC-Fr). View Larger

LYVE‑1 in Mouse Liver. LYVE-1 was detected in perfusion fixed frozen sections of mouse liver using 15 µg/mL Goat Anti-Mouse LYVE-1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2125) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; CTS008) and counterstained with hematoxylin (blue). Specific labeling was localized to the cytoplasm of endothelial cells in sinusoids. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.

Western Blot Detection of Mouse LYVE-1 antibody by Western Blot. View Larger

Detection of Mouse LYVE‑1 by Western Blot. Western blot shows lysates of mouse liver tissue and bEnd.3 mouse brain endothelial cell line. PVDF membrane was probed with 0.25 µg/mL of Goat Anti-Mouse LYVE-1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2125) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF019). A specific band was detected for LYVE-1 at approximately 60-65 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: LYVE-1

Lymphatic vessel endothelial hyaluronan (HA) receptor-1 (LYVE-1) is a recently identified receptor of HA, a linear high molecular weight polymer composed of alternating units of D-glucuronic acid and N-acetyl-D-glucosamine. HA is found in the extracellular matrix of most animal tissues and in body fluids. It modulates cell behavior and functions during tissue remodeling, development, homeostasis, and disease. The turnover of HA (several grams/day in humans) occurs primarily in the lymphatics and liver, the two major clearance systems that catabolize approximately 85% and 15% of HA, respectively. LYVE-1 shares 41% homology with the other known HA receptor, CD44. The homology between the two proteins increases to 61% within the HA binding domain. The HA binding domain, known as the link module, is a common structural motif found in other HA binding proteins such as link protein, aggrecan and versican. Human and mouse LYVE-1 share 69% amino acid sequence identity.

LYVE-1 is primarily expressed on both the luminal and abluminal surfaces of lymphatic vessels. In addition, LYVE-1 is also present in normal hepatic blood sinusoidal endothelial cells. LYVE-1 mediates the endocytosis of HA and may transport HA from tissue to lymph by transcytosis, delivering HA to lymphatic capillaries for removal and degradation in the regional lymph nodes. Because of its restricted expression patterns, LYVE-1, along with other lymphatic proteins such as VEGF R3, podoplanin and the homeobox protein propero-related (Prox-1), constitute a set of markers useful for distinguishing between lymphatic and blood microvasculature.

Long Name
Lymphatic Vessel Endothelial Hyaluronan Receptor 1
Entrez Gene IDs
10894 (Human); 114332 (Mouse); 293186 (Rat)
Alternate Names
cell surface retention sequence binding protein-1; Cell surface retention sequence-binding protein 1; CRSBP1; CRSBP-1; extracellular link domain containing 1; extracellular link domain-containing 1; Extracellular link domain-containing protein 1; HAR; Hyaluronic acid receptor; lymphatic vessel endothelial hyaluronan receptor 1; lymphatic vessel endothelial hyaluronic acid receptor 1; LYVE1; LYVE-1; UNQ230/PRO263; XLKD1

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Citations for Mouse LYVE-1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

75 Citations: Showing 1 - 10
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  1. Primary Cilium in Neural Crest Cells Crucial for Anterior Segment Development and Corneal Avascularity
    Authors: Seo, S;Sonn, SK;Kweon, HY;Jin, J;Kume, T;Ko, JY;Park, JH;Oh, GT;
    Investigative ophthalmology & visual science
    Species: Viral
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  2. Endothelial Erg Regulates Expression of Pulmonary Lymphatic Junctional and Inflammation Genes in Mouse Lungs Impacting Lymphatic Transport
    Authors: Chakraborty, A;Kim, A;AlAbdullatif, S;Campbell, JD;Alekseyev, YO;Kaplan, U;Dambal, V;Ligresti, G;Trojanowska, M;
    Research square
    Species: Murine polyomavirus strain A3, Human hepegivirus
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  3. 15-Lipoxygenase promotes resolution of inflammation in lymphedema by controlling Treg cell function through IFN-?
    Authors: Zamora, A;Nougué, M;Verdu, L;Balzan, E;Draia-Nicolau, T;Benuzzi, E;Pujol, F;Baillif, V;Lacazette, E;Morfoisse, F;Galitzky, J;Bouloumié, A;Dubourdeau, M;Chaput, B;Fazilleau, N;Malloizel-Delaunay, J;Bura-Rivière, A;Prats, AC;Garmy-Susini, B;
    Nature communications
    Species: Murine polyomavirus strain A3
    Sample Types: Whole Tissue
    Applications: IF/IHC
  4. Visualization of Organ-Specific Lymphatic Growth: An Efficient Approach to Labeling Molecular Markers in Cleared Tissues
    Authors: C Christ, Z Jakus
    International Journal of Molecular Sciences, 2023-03-07;24(6):.
    Species: Mouse, Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  5. VLA-4 suppression by senescence signals regulates meningeal immunity and leptomeningeal metastasis
    Authors: J Li, D Huang, B Lei, J Huang, L Yang, M Nie, S Su, Q Zhao, Y Wang
    Elife, 2022-12-09;11(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  6. Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model
    Authors: A Axelsson R, H Wakimoto, DM DeLaughter, D Reichart, J Gorham, DA Conner, M Lun, CK Probst, N Sakai, RS Knipe, SB Montesi, B Shea, LP Adam, LA Leinwand, W Wan, ES Choi, EL Lindberg, G Patone, M Noseda, N Hübner, CE Seidman, AM Tager, JG Seidman, CY Ho
    Proceedings of the National Academy of Sciences of the United States of America, 2022-07-05;119(28):e2204174119.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  7. Orphan G-Protein Coupled Receptor GPRC5B Is Critical for Lymphatic Development
    Authors: W Xu, NP Nelson-Man, L Bálint, HB Kwon, RB Davis, DCM Dy, JM Dunleavey, B St Croix, KM Caron
    International Journal of Molecular Sciences, 2022-05-20;23(10):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  8. Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis
    Authors: O Meçe, D Houbaert, ML Sassano, T Durré, H Maes, M Schaaf, S More, M Ganne, M García-Cab, M Borri, J Verhoeven, M Agrawal, K Jacobs, G Bergers, S Blacher, B Ghesquière, M Dewerchin, JV Swinnen, S Vinckier, MS Soengas, P Carmeliet, A Noël, P Agostinis
    Nature Communications, 2022-05-19;13(1):2760.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  9. ADAMTS2 and ADAMTS14 substitute ADAMTS3 in adults for proVEGFC activation and lymphatic homeostasis
    Authors: L Dupont, L Joannes, F Morfoisse, S Blacher, C Monseur, CF Deroanne, A Noël, AC Colige
    JCI Insight, 2022-04-22;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  10. Remodeling lymphatic vessels in intrinsically aged skin on SKH-1 mouse using low dose 5-aminolevulinic acid photodynamic therapy via VEGF-C/VEGFR3 pathway
    Authors: Y Yang, S Shen, Y Cao, D Wang, Z Kang, P Wang, X Wang
    Photodiagnosis and photodynamic therapy, 2022-04-06;0(0):102851.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  11. Angiogenic and molecular diversity determine hepatic melanoma metastasis and response to anti-angiogenic treatment
    Authors: SA Wohlfeil, V Häfele, B Dietsch, C Weller, C Sticht, AS Jauch, M Winkler, CD Schmid, AL Irkens, A Olsavszky, K Schledzews, PS Reiners-Ko, S Goerdt, C Géraud
    Journal of Translational Medicine, 2022-02-02;20(1):62.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC/IF
  12. GPR182 limits antitumor immunity via chemokine scavenging in mouse melanoma models
    Authors: RJ Torphy, Y Sun, R Lin, A Caffrey-Ca, Y Fujiwara, F Ho, EN Miller, MD McCarter, TR Lyons, RD Schulick, RM Kedl, Y Zhu
    Nature Communications, 2022-01-10;13(1):97.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  13. Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation
    Authors: J Heil, V Olsavszky, K Busch, K Klapproth, C de la Torr, C Sticht, K Sandorski, J Hoffmann, H Schönhaber, J Zierow, M Winkler, CD Schmid, T Staniczek, DE Daniels, J Frayne, G Metzgeroth, D Nowak, S Schneider, M Neumaier, V Weyer, C Groden, HJ Gröne, K Richter, C Mogler, MM Taketo, K Schledzews, C Géraud, S Goerdt, PS Koch
    Nature Communications, 2021-11-29;12(1):6963.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  14. Npr2 mutant mice show vasodilation and undeveloped adipocytes in mesentery
    Authors: C Sogawa-Fuj, Y Fujiwara, A Hanagata, Q Yang, T Mihara, N Kaji, T Kunieda, M Hori
    Bmc Research Notes, 2021-11-27;14(1):438.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  15. Expanded renal lymphatics improve recovery following kidney injury
    Authors: G Baranwal, HA Creed, LM Black, A Auger, AM Quach, R Vegiraju, HE Eckenrode, A Agarwal, JM Rutkowski
    Physiological Reports, 2021-11-01;9(22):e15094.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  16. Vegfr3-tdTomato, a reporter mouse for microscopic visualization of lymphatic vessel by multiple modalities
    Authors: E Redder, N Kirschnick, S Bobe, R Hägerling, NR Hansmeier, F Kiefer
    PLoS ONE, 2021-09-20;16(9):e0249256.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  17. KRAS-driven model of Gorham-Stout disease effectively treated with trametinib
    Authors: N Homayun Se, AL McCarter, R Helaers, C Galant, LM Boon, P Brouillard, M Vikkula, MT Dellinger
    JCI Insight, 2021-08-09;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  18. 3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine
    Authors: CC Clement, A D'Alessand, S Thangaswam, S Chalmers, R Furtado, S Spada, G Mondanelli, F Ianni, S Gehrke, M Gargaro, G Manni, LCL Cara, P Runge, WL Tsai, S Karaman, J Arasa, R Fernandez-, A Beck, A Macchiarul, M Gadina, C Halin, F Fallarino, M Skobe, M Veldhoen, S Moretti, S Formenti, S Demaria, RK Soni, R Galarini, R Sardella, G Lauvau, C Putterman, K Alitalo, U Grohmann, L Santambrog
    Nature Communications, 2021-07-21;12(1):4447.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: IHC
  19. Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema
    Authors: D Sz?ke, G Kovács, É Kemecsei, L Bálint, K Szoták-Ajt, P Aradi, A Styevkóné, BL Mui, YK Tam, TD Madden, K Karikó, RP Kataru, MJ Hope, D Weissman, BJ Mehrara, N Pardi, Z Jakus
    Nature Communications, 2021-06-08;12(1):3460.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  20. Single-Cell Transcriptional Heterogeneity of Lymphatic Endothelial Cells in Normal and Inflamed Murine Lymph Nodes
    Authors: E Sibler, Y He, L Ducoli, N Keller, N Fujimoto, LC Dieterich, M Detmar
    Cells, 2021-06-02;10(6):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  21. Ex Vivo-Induced Bone Marrow-Derived Myeloid Suppressor Cells Prevent Corneal Allograft Rejection in Mice
    Authors: J Zhu, T Inomata, K Fujimoto, K Uchida, K Fujio, K Nagino, M Miura, N Negishi, Y Okumura, Y Akasaki, K Hirosawa, M Kuwahara, A Eguchi, H Shokirova, A Yanagawa, A Midorikawa, A Murakami
    Investigative Ophthalmology & Visual Science, 2021-06-01;62(7):3.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  22. New lymphatic cell formation is associated with damaged brain tissue clearance after penetrating traumatic brain injury
    Authors: FW Meng, JT Yu, JY Chen, PF Yang
    Scientific Reports, 2021-05-13;11(1):10193.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  23. Mesenchymal stem cells induce tumor stroma formation and epithelial?mesenchymal transition through SPARC expression in colorectal cancer
    Authors: T Naito, R Yuge, Y Kitadai, H Takigawa, Y Higashi, T Kuwai, K Kuraoka, S Tanaka, K Chayama
    Oncology reports, 2021-04-28;45(6):.
    Species: Human
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC
  24. Topical administration of the kappa opioid receptor agonist nalfurafine suppresses corneal neovascularization and inflammation
    Authors: H Shokirova, T Inomata, T Saitoh, J Zhu, K Fujio, Y Okumura, A Yanagawa, K Fujimoto, J Sung, A Eguchi, M Miura, K Nagino, K Hirosawa, M Kuwahara, Y Akasaki, H Nagase, A Murakami
    Scientific Reports, 2021-04-21;11(1):8647.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  25. Tertiary lymphoid organs are associated with the progression of kidney damage and regulated by interleukin-17A
    Authors: R Luo, Y Cheng, D Chang, T Liu, L Liu, G Pei, N Zhang, Z Wang, K Guo, W Chen, M Li, L Fan, C Zhang, Y Li, W Dai, M Zuo, Y Xu, Y Yao, S Ge, G Xu
    Theranostics, 2021-01-01;11(1):117-131.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  26. Blood and lymphatic systems are segregated by the FLCN tumor suppressor
    Authors: I Tai-Nagara, Y Hasumi, D Kusumoto, H Hasumi, K Okabe, T Ando, F Matsuzaki, F Itoh, H Saya, C Liu, W Li, YS Mukouyama, W Marston Li, X Liu, M Hirashima, Y Suzuki, S Funasaki, Y Satou, M Furuya, M Baba, Y Kubota
    Nature Communications, 2020-12-09;11(1):6314.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  27. Novel immunotherapeutic effects of topically administered ripasudil (K-115) on corneal allograft survival
    Authors: T Inomata, K Fujimoto, Y Okumura, J Zhu, K Fujio, H Shokirova, M Miura, M Okano, T Funaki, J Sung, N Negishi, A Murakami
    Sci Rep, 2020-11-13;10(1):19817.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  28. Eye lymphatic defects induced by bone morphogenetic protein 9 deficiency have no functional consequences on intraocular pressure
    Authors: M Subileau, N Acar, A Carret, L Bretillon, I Vilgrain, S Bailly, D Vittet
    Sci Rep, 2020-09-29;10(1):16040.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  29. Defective development and microcirculation of intestine in Npr2 mutant mice
    Authors: C Sogawa-Fuj, A Hanagata, Y Fujiwara, Y Ishida, H Tomiyasu, T Kunieda, H Nakatomi, M Hori
    Sci Rep, 2020-09-08;10(1):14761.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  30. Inhibition of receptor activity-modifying protein 1 suppresses the development of endometriosis and the formation of blood and lymphatic vessels
    Authors: M Honda, Y Ito, K Hattori, K Hosono, K Sekiguchi, K Tsujikawa, N Unno, M Majima
    J. Cell. Mol. Med., 2020-09-01;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  31. S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling
    Authors: X Geng, K Yanagida, RG Akwii, D Choi, L Chen, Y Ho, B Cha, MR Mahamud, K Berman de, H Ichise, H Chen, J Wythe, CM Mikelis, T Hla, RS Srinivasan
    JCI Insight, 2020-07-23;0(0):.
    Species: Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  32. Characterizing Lymphangiogenesis and Concurrent Inflammation in Adipose Tissue in Response to VEGF-D
    Authors: A Chakrabort, CK Scogin, K Rizwan, TS Morley, JM Rutkowski
    Front Physiol, 2020-04-22;11(0):363.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  33. Progesterone Receptor Serves the Ovary as a Trigger of Ovulation and a Terminator of Inflammation
    Authors: CJ Park, PC Lin, S Zhou, R Barakat, ST Bashir, JM Choi, JA Cacioppo, OR Oakley, DM Duffy, JP Lydon, CJ Ko
    Cell Rep, 2020-04-14;31(2):107496.
    Species: Mouse
    Sample Types: Granulosa Cells
    Applications: IHC
  34. VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours
    Authors: E Song, T Mao, H Dong, LSB Boisserand, S Antila, M Bosenberg, K Alitalo, JL Thomas, A Iwasaki
    Nature, 2020-01-15;577(7792):689-694.
    Species: Mouse
    Sample Types: Tissue
    Applications: IF
  35. Receptor?interacting serine/threonine?protein kinase 1 promotes the progress and lymph metastasis of gallbladder cancer
    Authors: G Zhu, Q Du, X Chen, X Wang, N Tang, F She, Y Chen
    Oncol. Rep., 2019-09-23;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  36. An important role of cutaneous lymphatic vessels in coordinating and promoting anagen hair follicle growth
    Authors: SY Yoon, LC Dieterich, S Karaman, ST Proulx, SB Bachmann, C Sciaroni, M Detmar
    PLoS ONE, 2019-07-25;14(7):e0220341.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  37. Placental chemokine compartmentalisation: A novel mammalian molecular control mechanism
    Authors: KM Lee, GJ Wilson, M Pingen, A Fukuoka, CAH Hansell, R Bartolini, L Medina-Rui, GJ Graham
    PLoS Biol., 2019-05-29;17(5):e3000287.
    Species: Mouse, Transgenic Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: Flow Cytometry, IHC
  38. Compartmentalized gut lymph node drainage dictates adaptive immune responses
    Authors: D Esterházy, MCC Canesso, L Mesin, PA Muller, TBR de Castro, A Lockhart, M ElJalby, AMC Faria, D Mucida
    Nature, 2019-04-15;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  39. Lymphatic impairment leads to pulmonary tertiary lymphoid organ formation and alveolar damage
    Authors: HO Reed, L Wang, J Sonett, M Chen, J Yang, L Li, P Aradi, Z Jakus, J D'Armiento, WW Hancock, ML Kahn
    J. Clin. Invest., 2019-04-04;129(6):2514-2526.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  40. Associating liver partition and portal vein ligation for staged hepatectomy: establishment of an animal model with insufficient liver remnant
    Authors: A Dili, V Lebrun, C Bertrand, IA Leclercq
    Lab. Invest., 2019-01-21;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  41. Bone Morphogenetic Protein 9 Regulates Early Lymphatic-Specified Endothelial Cell Expansion during Mouse Embryonic Stem Cell Differentiation
    Authors: M Subileau, G Merdzhanov, D Ciais, V Collin-Fau, JJ Feige, S Bailly, D Vittet
    Stem Cell Reports, 2018-12-27;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  42. Lymphatic Vascular Structures: A New Aspect in Proliferative Diabetic Retinopathy
    Authors: E Gucciardo, S Loukovaara, P Salven, K Lehti
    Int J Mol Sci, 2018-12-13;19(12):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  43. uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis
    Authors: T Durré, F Morfoisse, C Erpicum, M Ebroin, S Blacher, M García-Cab, C Deroanne, T Louis, C Balsat, M Van de Vel, S Kaijalaine, F Kridelka, L Engelholm, I Struman, K Alitalo, N Behrendt, J Paupert, A Noel
    Nat Commun, 2018-12-05;9(1):5178.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  44. CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema
    Authors: GD García Nor, CL Ly, DA Cuzzone, RP Kataru, GE Hespe, JS Torrisi, JJ Huang, JC Gardenier, IL Savetsky, MD Nitti, JZ Yu, S Rehal, BJ Mehrara
    Nat Commun, 2018-05-17;9(1):1970.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  45. RIP1 regulates TNF-?-mediated lymphangiogenesis and lymphatic metastasis in gallbladder cancer by modulating the NF-?B-VEGF-C pathway
    Authors: CZ Li, XJ Jiang, B Lin, HJ Hong, SY Zhu, L Jiang, XQ Wang, NH Tang, FF She, YL Chen
    Onco Targets Ther, 2018-05-16;11(0):2875-2890.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  46. VEGF-C promotes the development of lymphatics in bone and bone loss
    Authors: D Hominick, A Silva, N Khurana, Y Liu, PC Dechow, JQ Feng, B Pytowski, JM Rutkowski, K Alitalo, MT Dellinger
    Elife, 2018-04-05;7(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  47. Mir-126 is a conserved modulator of lymphatic development
    Authors: Z Kontarakis, A Rossi, S Ramas, MT Dellinger, DYR Stainier
    Dev. Biol., 2018-03-15;0(0):.
    Species: Mouse
    Sample Types: Embryo
    Applications: Western Blot
  48. Gamma-interferon exerts a critical early restriction on replication and dissemination of yellow fever virus vaccine strain 17D-204
    Authors: LKM Lam, AM Watson, KD Ryman, WB Klimstra
    Npj Vaccines, 2018-01-23;3(0):5.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  49. Indian Hedgehog Suppresses a Stromal Cell-Driven Intestinal Immune Response
    Authors: BF Westendorp, NVJA Büller, ON Karpus, WA van Dop, J Koster, R Versteeg, PJ Koelink, CY Snel, S Meisner, JJTH Roelofs, A Uhmann, E Ver Loren, J Heijmans, H Hahn, V Muncan, ME Wildenberg, GR van den Br
    Cell Mol Gastroenterol Hepatol, 2017-09-05;5(1):67-82.e1.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  50. Targeting VEGFR-3/-2 signaling pathways with AD0157: a potential strategy against tumor-associated lymphangiogenesis and lymphatic metastases
    Authors: M García-Cab, J Paupert, S Blacher, M Van de Vel, AR Quesada, MA Medina, A Noël
    J Hematol Oncol, 2017-06-19;10(1):122.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  51. cIAP2 promotes gallbladder cancer invasion and lymphangiogenesis by activating the NF-?B pathway
    Authors: X Jiang, C Li, B Lin, H Hong, L Jiang, S Zhu, X Wang, N Tang, X Li, F She, Y Chen
    Cancer Sci., 2017-05-31;108(6):1144-1156.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  52. Mechanotransduction activates canonical Wnt/?-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves
    Authors: Boksik Cha
    Genes Dev, 2016-06-16;30(12):1454-69.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  53. Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD
    J Clin Invest, 2016-05-09;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  54. CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity
    J Clin Invest, 2016-05-03;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Immunoprecipitation
  55. Thy1+IL-7+ lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation
    Proc Natl Acad Sci USA, 2016-05-02;113(20):E2842-51.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  56. Sox7, Sox17, and Sox18 Cooperatively Regulate Vascular Development in the Mouse Retina.
    Authors: Zhou Y, Williams J, Smallwood P, Nathans J
    PLoS ONE, 2015-12-02;10(12):e0143650.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  57. Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development.
    Authors: Geng X, Cha B, Mahamud M, Lim K, Silasi-Mansat R, Uddin M, Miura N, Xia L, Simon A, Engel J, Chen H, Lupu F, Srinivasan R
    Dev Biol, 2015-11-02;409(1):218-33.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  58. Lymph flow regulates collecting lymphatic vessel maturation in vivo.
    Authors: Sweet D, Jimenez J, Chang J, Hess P, Mericko-Ishizuka P, Fu J, Xia L, Davies P, Kahn M
    J Clin Invest, 2015-07-27;125(8):2995-3007.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  59. A transgenic Prox1-Cre-tdTomato reporter mouse for lymphatic vessel research.
    Authors: Bianchi R, Teijeira A, Proulx S, Christiansen A, Seidel C, Rulicke T, Makinen T, Hagerling R, Halin C, Detmar M
    PLoS ONE, 2015-04-07;10(4):e0122976.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  60. Bone marrow-derived mesenchymal stem cells drive lymphangiogenesis.
    Authors: Maertens L, Erpicum C, Detry B, Blacher S, Lenoir B, Carnet O, Pequeux C, Cataldo D, Lecomte J, Paupert J, Noel A
    PLoS ONE, 2014-09-15;9(9):e106976.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  61. VEGF-C-dependent stimulation of lymphatic function ameliorates experimental inflammatory bowel disease.
    Authors: D'Alessio S, Correale C, Tacconi C, Gandelli A, Pietrogrande G, Vetrano S, Genua M, Arena V, Spinelli A, Peyrin-Biroulet L, Fiocchi C, Danese S
    J Clin Invest, 2014-08-08;124(9):3863-78.
    Species: Human, Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  62. Schlemm's canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process.
    Authors: Kizhatil, Krishnak, Ryan, Margaret, Marchant, Jeffrey, Henrich, Stephen, John, Simon W
    PLoS Biol, 2014-07-22;12(7):e1001912.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  63. Lymphatic function is required prenatally for lung inflation at birth.
    Authors: Jakus Z, Gleghorn J, Enis D, Sen A, Chia S, Liu X, Rawnsley D, Yang Y, Hess P, Zou Z, Yang J, Guttentag S, Nelson C, Kahn M
    J Exp Med, 2014-04-14;211(5):815-26.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  64. Deletion of tetraspanin CD9 diminishes lymphangiogenesis in vivo and in vitro.
    Authors: Iwasaki T, Takeda Y, Maruyama K, Yokosaki Y, Tsujino K, Tetsumoto S, Kuhara H, Nakanishi K, Otani Y, Jin Y, Kohmo S, Hirata H, Takahashi R, Suzuki M, Inoue K, Nagatomo I, Goya S, Kijima T, Kumagai T, Tachibana I, Kawase I, Kumanogoh A
    J Biol Chem, 2012-12-05;288(4):2118-31.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Selection
  65. Rho-family GTPase Cdc42 controls migration of Langerhans cells in vivo.
    Authors: Luckashenak N, Wahe A, Breit K, Brakebusch C, Brocker T
    J Immunol, 2012-12-03;190(1):27-35.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  66. Angiopoietin-1 is essential in mouse vasculature during development and in response to injury.
    Authors: Jeansson M, Gawlik A, Anderson G
    J. Clin. Invest., 2011-05-23;121(6):2278-89.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr, IHC-P
  67. Sphingosine 1-Phosphate-Induced Motility and Endocytosis of Dendritic Cells Is Regulated by SWAP-70 through RhoA.
    Authors: Ocana-Morgner C, Reichardt P, Chopin M, Braungart S, Wahren C, Gunzer M, Jessberger R
    J. Immunol., 2011-03-18;186(9):5345-55.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  68. Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3.
    Authors: Xu Y, Yuan L, Mak J, Pardanaud L, Caunt M, Kasman I, Larrivee B, Del Toro R, Suchting S, Medvinsky A, Silva J, Yang J, Thomas JL, Koch AW, Alitalo K, Eichmann A, Bagri A
    J. Cell Biol., 2010-01-11;188(1):115-30.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC-Fr
  69. ALK1 signaling regulates early postnatal lymphatic vessel development.
    Authors: Niessen K, Zhang G, Ridgway JB, Chen H, Yan M
    Blood, 2009-11-10;115(8):1654-61.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  70. Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth.
    Authors: Cho WG, Albuquerque RJ, Kleinman ME, Tarallo V, Greco A, Nozaki M, Green MG, Baffi JZ, Ambati BK, De Falco M, Alexander JS, Brunetti A, De Falco S, Ambati J
    Proc. Natl. Acad. Sci. U.S.A., 2009-04-09;106(17):7137-42.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  71. Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes.
    Authors: Katagiri K, Katakai T, Ebisuno Y, Ueda Y, Okada T, Kinashi T
    EMBO J., 2009-04-02;28(9):1319-31.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  72. Organizer-like reticular stromal cell layer common to adult secondary lymphoid organs.
    Authors: Katakai T, Suto H, Sugai M, Gonda H, Togawa A, Suematsu S, Ebisuno Y, Katagiri K, Kinashi T, Shimizu A
    J. Immunol., 2008-11-01;181(9):6189-200.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  73. Dynamic changes occur in patterns of endometrial EFNB2/EPHB4 expression during the period of spiral arterial modification in mice.
    Authors: Zhang J, Dong H, Wang B, Zhu S, Croy BA
    Biol. Reprod., 2008-05-07;79(3):450-8.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  74. Thymic stromal lymphopoietin transgenic mice develop cryoglobulinemia and hepatitis with similarities to human hepatitis C liver disease.
    Authors: Kowalewska J, Muhlfeld AS, Hudkins KL, Yeh MM, Farr AG, Ravetch JV, Alpers CE
    Am. J. Pathol., 2007-03-01;170(3):981-9.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  75. Pericytes and endothelial precursor cells: cellular interactions and contributions to malignancy.
    Authors: Bagley RG, Weber W, Rouleau C, Teicher BA
    Cancer Res., 2005-11-01;65(21):9741-50.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC

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Mouse LYVE-1 Antibody
By Evan Phillips on 01/08/2021
Application: ICC/IF Sample Tested: Heart tissue Species: Mouse
Immunocytochemistry/Immunofluorescence Mouse LYVE-1 Antibody AF2125
Mouse LYVE-1 Antibody
By Anonymous on 02/02/2017
Application: IHC Sample Tested: Lymph node tissue Species: Mouse

In paraffin embedded sample.
Antigen retrieval with Tris-EDTA Buffer pH 9.0 and fixation with Methanol.
Blocking with TBS 2% BSA -0.5% Triton X-100.
Incubation of Lyve1 (AF2125) at a dilution of 1:400 (O/N at 4C).

Mouse LYVE-1 Antibody
By Anonymous on 09/07/2016
Application: Whole mount immunofluorescence Sample Tested: Whole-mount ear dermis Species: Mouse

Mouse ear dermis was fixed in 2%PFA and blocked/permeabilized overnight in TBS/5% donkey serum/0.5% Tx100 before incubation in AF2125 at a dilution of 1:250 (O/N at 4C). Antibody was then detected using an alexafluor 488 labeled donkey anti goat secondary.

Other Mouse LYVE-1 Antibody AF2125