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Mouse VEGFR3/Flt-4 Antibody

Catalog #: AF743
72 Citations 3 Reviews Datasheet / COA / SDS
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AF743
AF743-SP
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Detection of VEGFR3/Flt‑4 in bEnd.3 Mouse Cell Line by Flow Cytometry.
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Citations (72)
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Reviews (3)
Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Mouse VEGFR3/Flt-4 Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse VEGFR3/Flt-4 in direct ELISAs and Western blots. In direct ELISAs, approximately 30% cross-reactivity with recombinant human (rh) VEGFR3 is observed and less than 5% cross-reactivity with recombinant mouse VEGFR2 is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse VEGFR3/Flt-4
Tyr25-Asp770
Accession # P35917
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Mouse VEGFR3/Flt‑4 Fc Chimera (Catalog # 743-R3)
Flow Cytometry
0.25 µg/106 cells
See below
CyTOF-ready
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of VEGFR3/Flt-4 antibody in bEnd.3 Mouse Cell Line antibody by Flow Cytometry. View Larger

Detection of VEGFR3/Flt‑4 in bEnd.3 Mouse Cell Line by Flow Cytometry. bEnd.3 cells, a mouse endothelioma cell line, was stained with Goat Anti-Mouse VEGFR3/Flt-4 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF743, filled histogram) or isotype control antibody (Catalog # AB-108-C, open histogram), followed by PE-conjugated Anti-Goat IgG Secondary Antibody (Catalog # F0107).

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: VEGFR3/Flt-4

VEGFR3 (Flt-4), together with VEGFR1 (Flt-1) and VEGFR2 (KDR/Flk-1), belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domains and kinase insert domains in their intracellular regions. The expression of these receptors is almost exclusively restricted to the endothelial cells. These receptors are likely to play essential roles in vasculogenesis and angiogenesis.

In adults, VEGFR3 expression is restricted to the endothelial cells of the lymphatic vessels. Mouse VEGFR3 cDNA encodes a 1363 amino acid (aa) residue precursor protein with a 24 aa residue signal peptide. Mature VEGFR3 has a 751 aa residue extracellular domain, a 22 aa residue hydrophobic transmembrane domain and a 565 aa residue cytoplasmic domain. The polypeptide sequences of murine Flt-4 is 88% identical to the human homologue. VEGFR3 has been reported to serve as the receptors for VEGF-C and VEGF-D.

References
  1. Finnerty, H. et al. (1993) Oncogene 8:2293.
  2. Joukov, V. et al. (1996) EMBO J. 15:290.
  3. Achen, M. et al. (1998) Proc. Natl. Acad. Sci. USA 95:548.
Long Name
Vascular Endothelial Growth Factor Receptor 3
Entrez Gene IDs
2324 (Human); 14257 (Mouse)
Alternate Names
EC 2.7.10; EC 2.7.10.1; FLT4; Flt-4; fms-related tyrosine kinase 4; LMPH1A; PCLFLT41; soluble VEGFR3 variant 1; soluble VEGFR3 variant 2; soluble VEGFR3 variant 3; Tyrosine-protein kinase receptor FLT4; vascular endothelial growth factor receptor 3; VEGF R3; VEGFR3; VEGFR-3; VEGFR3Fms-like tyrosine kinase 4

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Citations for Mouse VEGFR3/Flt-4 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

72 Citations: Showing 1 - 10
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  1. Piezo1 regulates meningeal lymphatic vessel drainage and alleviates excessive CSF accumulation
    Authors: Choi, D;Park, E;Choi, J;Lu, R;Yu, JS;Kim, C;Zhao, L;Yu, J;Nakashima, B;Lee, S;Singhal, D;Scallan, JP;Zhou, B;Koh, CJ;Lee, E;Hong, YK;
    Nature neuroscience
    Species: Murine polyomavirus strain A3, Viral
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  2. Influenza Induces Lung Lymphangiogenesis Independent of YAP/TAZ Activity in Lymphatic Endothelial Cells
    Authors: Crossey, E;Carty, S;Shao, F;Henao-Vasquez, J;Ysasi, AB;Zeng, M;Hinds, A;Lo, M;Tilston-Lunel, A;Varelas, X;Jones, MR;Fine, A;
    Research square
    Species: Murine polyomavirus strain A3
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  3. VEGFR-3 signaling restrains the neuron-macrophage crosstalk during neurotropic viral infection
    Authors: Qi, L;Li, X;Zhang, F;Zhu, X;Zhao, Q;Yang, D;Hao, S;Li, T;Li, X;Tian, T;Feng, J;Sun, X;Wang, X;Gao, S;Wang, H;Ye, J;Cao, S;He, Y;Wang, H;Wei, B;
    Cell reports
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  4. A Prox1 enhancer represses haematopoiesis in the lymphatic vasculature
    Authors: J Kazenwadel, P Venugopal, A Oszmiana, J Toubia, L Arriola-Ma, V Panara, SG Piltz, C Brown, W Ma, AW Schreiber, K Koltowska, S Taoudi, PQ Thomas, HS Scott, NL Harvey
    Nature, 2023-01-25;614(7947):343-348.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  5. An analysis modality for vascular structures combining tissue-clearing technology and topological data analysis
    Authors: K Takahashi, K Abe, SI Kubota, N Fukatsu, Y Morishita, Y Yoshimatsu, S Hirakawa, Y Kubota, T Watabe, S Ehata, HR Ueda, T Shimamura, K Miyazono
    Nature Communications, 2022-09-12;13(1):5239.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  6. Meningeal lymphatic vessels mediate neurotropic viral drainage from the central nervous system
    Authors: X Li, L Qi, D Yang, S Hao, F Zhang, X Zhu, Y Sun, C Chen, J Ye, J Yang, L Zhao, DM Altmann, S Cao, H Wang, B Wei
    Nature Neuroscience, 2022-05-06;25(5):577-587.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  7. Live imaging of neolymphangiogenesis identifies acute antimetastatic roles of dsRNA mimics
    Authors: D Olmeda, D Cerezo-Wal, C Mucientes, TG Calvo, E Cañón, D Alonso-Cur, N Ibarz, J Muñoz, JL Rodriguez-, P Ortiz-Rome, S Ortega, MS Soengas
    Embo Molecular Medicine, 2021-11-11;0(0):e12924.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  8. Vegfr3-tdTomato, a reporter mouse for microscopic visualization of lymphatic vessel by multiple modalities
    Authors: E Redder, N Kirschnick, S Bobe, R Hägerling, NR Hansmeier, F Kiefer
    PLoS ONE, 2021-09-20;16(9):e0249256.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  9. Chronic VEGFR-3 signaling preserves dendritic arborization and sensitization under stress
    Authors: A Chakrabort, R Upadhya, TA Usman, AK Shetty, JM Rutkowski
    Brain, Behavior, and Immunity, 2021-08-11;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  10. Dynamic cell contacts between periportal mesenchyme and ductal epithelium act as a rheostat for liver cell proliferation
    Authors: L Cordero-Es, AM Dowbaj, TN Kohler, B Strauss, O Sarlidou, G Belenguer, C Pacini, NP Martins, R Dobie, JR Wilson-Kan, R Butler, N Prior, P Serup, F Jug, NC Henderson, F Hollfelder, M Huch
    Cell Stem Cell, 2021-08-02;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  11. Targeting local lymphatics to ameliorate heterotopic ossification via FGFR3-BMPR1a pathway
    Authors: D Zhang, J Huang, X Sun, H Chen, S Huang, J Yang, X Du, Q Tan, F Luo, R Zhang, S Zhou, W Jiang, Z Ni, Z Wang, M Jin, M Xu, F Li, L Chen, M Liu, N Su, X Luo, L Yin, Y Zhu, JQ Feng, D Chen, H Qi, L Chen, Y Xie
    Nature Communications, 2021-07-19;12(1):4391.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  12. Efficient aortic lymphatic drainage is necessary for atherosclerosis regression induced by ezetimibe
    Authors: KP Yeo, HY Lim, CH Thiam, SH Azhar, C Tan, Y Tang, WQ See, XH Koh, MH Zhao, ML Phua, A Balachande, Y Tan, SY Lim, HS Chew, LG Ng, V Angeli
    Science Advances, 2020-12-11;6(50):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  13. Blood and lymphatic systems are segregated by the FLCN tumor suppressor
    Authors: I Tai-Nagara, Y Hasumi, D Kusumoto, H Hasumi, K Okabe, T Ando, F Matsuzaki, F Itoh, H Saya, C Liu, W Li, YS Mukouyama, W Marston Li, X Liu, M Hirashima, Y Suzuki, S Funasaki, Y Satou, M Furuya, M Baba, Y Kubota
    Nature Communications, 2020-12-09;11(1):6314.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  14. Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi
    Authors: SP Hong, MJ Yang, H Cho, I Park, H Bae, K Choe, SH Suh, RH Adams, K Alitalo, D Lim, GY Koh
    Nat Commun, 2020-08-14;11(1):4102.
    Species: Mouse
    Sample Types: Serum, Whole Tissue
    Applications: IHC, Western Blot
  15. S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling
    Authors: X Geng, K Yanagida, RG Akwii, D Choi, L Chen, Y Ho, B Cha, MR Mahamud, K Berman de, H Ichise, H Chen, J Wythe, CM Mikelis, T Hla, RS Srinivasan
    JCI Insight, 2020-07-23;0(0):.
    Species: Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  16. Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation
    Authors: I Martinez-C, Y Zhang, M Petkova, H Ortsäter, S Sjöberg, SD Castillo, P Brouillard, L Libbrecht, D Saur, M Graupera, K Alitalo, L Boon, M Vikkula, T Mäkinen
    Nat Commun, 2020-06-08;11(1):2869.
    Species: Mouse
    Sample Types: Serum, Whole Tissue
    Applications: IHC, Western Blot
  17. Atypical cadherin Fat4 orchestrates lymphatic endothelial cell polarity in response to flow
    Authors: KL Betterman, DL Sutton, GA Secker, J Kazenwadel, A Oszmiana, L Lim, N Miura, L Sorokin, BM Hogan, ML Kahn, H McNeill, NL Harvey
    J. Clin. Invest., 2020-06-01;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Lysates, Whole Tissue
    Applications: IHC, Western Blot
  18. Transcriptional landscape of pulmonary lymphatic endothelial cells during fetal gestation
    Authors: TA Norman, AC Gower, F Chen, A Fine
    PLoS ONE, 2019-05-13;14(5):e0216795.
    Species: Mouse
    Sample Types: fetal lung tissue
    Applications: IHC-P
  19. Dynamic signature of lymphangiogenesis during acute kidney injury and chronic kidney disease
    Authors: A Zarjou, LM Black, S Bolisetty, AM Traylor, SA Bowhay, MZ Zhang, RC Harris, A Agarwal
    Lab. Invest., 2019-04-24;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: IHC-P, Western Blot
  20. Lymphatic impairment leads to pulmonary tertiary lymphoid organ formation and alveolar damage
    Authors: HO Reed, L Wang, J Sonett, M Chen, J Yang, L Li, P Aradi, Z Jakus, J D'Armiento, WW Hancock, ML Kahn
    J. Clin. Invest., 2019-04-04;129(6):2514-2526.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  21. Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/?-Catenin Signaling
    Authors: B Cha, X Geng, MR Mahamud, JY Zhang, L Chen, W Kim, EH Jho, Y Kim, D Choi, JB Dixon, H Chen, YK Hong, L Olson, TH Kim, BJ Merrill, MJ Davis, RS Srinivasan
    Cell Rep, 2018-10-16;25(3):571-584.e5.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  22. Unexpected contribution of lymphatic vessels to promotion of distant metastatic tumor spread
    Authors: Q Ma, LC Dieterich, K Ikenberg, SB Bachmann, J Mangana, ST Proulx, VC Amann, MP Levesque, R Dummer, P Baluk, DM McDonald, M Detmar
    Sci Adv, 2018-08-08;4(8):eaat4758.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  23. HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development
    Authors: S Gauvrit, A Villasenor, B Strilic, P Kitchen, MM Collins, R Marín-Juez, S Guenther, HM Maischein, N Fukuda, MA Canham, JM Brickman, CW Bogue, PS Jayaraman, DYR Stainier
    Nat Commun, 2018-07-13;9(1):2704.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  24. Expression of the Atypical Chemokine Receptor ACKR4 Identifies a Novel Population of Intestinal Submucosal Fibroblasts That Preferentially Expresses Endothelial Cell Regulators
    Authors: CA Thomson, SA van de Pav, M Stakenborg, E Labeeuw, G Matteoli, AM Mowat, RJB Nibbs
    J. Immunol., 2018-05-14;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  25. Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program
    Authors: M Frye, A Taddei, C Dierkes, I Martinez-C, M Fielden, H Ortsäter, J Kazenwadel, DP Calado, P Ostergaard, M Salminen, L He, NL Harvey, F Kiefer, T Mäkinen
    Nat Commun, 2018-04-17;9(1):1511.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  26. Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms
    Authors: Y Zhang, MH Ulvmar, L Stanczuk, I Martinez-C, M Frye, K Alitalo, T Mäkinen
    Nat Commun, 2018-04-03;9(1):1296.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC
  27. Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma
    Authors: J Kim, DY Park, H Bae, DY Park, D Kim, CK Lee, S Song, TY Chung, DH Lim, Y Kubota, YK Hong, Y He, HG Augustin, G Oliver, GY Koh
    J. Clin. Invest., 2017-09-18;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  28. Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1
    Authors: SK Jha, K Rauniyar, T Karpanen, VM Leppänen, P Brouillard, M Vikkula, K Alitalo, M Jeltsch
    Sci Rep, 2017-07-07;7(1):4916.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  29. Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine
    Authors: D Olmeda, D Cerezo-Wal, E Riveiro-Fa, PC Pennacchi, M Contreras-, N Ibarz, M Cifdaloz, X Catena, TG Calvo, E Cañón, D Alonso-Cur, J Suarez, L Osterloh, O Graña, F Mulero, D Megías, M Cañamero, JL Martínez-T, C Mondal, J Di Martino, D Lora, I Martinez-C, JJ Bravo-Cord, J Muñoz, S Puig, P Ortiz-Rome, JL Rodriguez-, S Ortega, MS Soengas
    Nature, 2017-06-28;546(7660):676-680.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  30. Apelin modulates pathological remodeling of lymphatic endothelium after myocardial infarction
    Authors: F Tatin, E Renaud-Gab, AC Godet, F Hantelys, F Pujol, F Morfoisse, D Calise, F Viars, P Valet, B Masri, AC Prats, B Garmy-Susi
    JCI Insight, 2017-06-15;2(12):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  31. VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis
    Authors: JY Jang, SY Choi, I Park, DY Park, K Choe, P Kim, YK Kim, BJ Lee, M Hirashima, Y Kubota, JW Park, SY Cheng, A Nagy, YJ Park, K Alitalo, M Shong, GY Koh
    EMBO Mol Med, 2017-06-01;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  32. FGF-dependent metabolic control of vascular development
    Authors: P Yu, K Wilhelm, A Dubrac, JK Tung, TC Alves, JS Fang, Y Xie, J Zhu, Z Chen, F De Smet, J Zhang, SW Jin, L Sun, H Sun, RG Kibbey, KK Hirschi, N Hay, P Carmeliet, TW Chittenden, A Eichmann, M Potente, M Simons
    Nature, 2017-05-03;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  33. Vitamin D inhibits lymphangiogenesis through VDR-dependent mechanisms
    Authors: S Yazdani, F Poosti, L Toro, J Wedel, R Mencke, K Mirkovi?, MH de Borst, JS Alexander, G Navis, H van Goor, J van den Bo, JL Hillebrand
    Sci Rep, 2017-03-17;7(0):44403.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  34. VEGFR3 Modulates Vascular Permeability by Controlling VEGF/VEGFR2 Signaling
    Authors: K Heinolaine, S Karaman, G D'Amico, T Tammela, R Sormunen, L Eklund, K Alitalo, G Zarkada
    Circ. Res, 2017-03-15;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Cells
    Applications: ICC, Western Blot
  35. Cell-matrix signals specify bone endothelial cells during developmental osteogenesis
    Authors: UH Langen, ME Pitulescu, JM Kim, R Enriquez-G, KK Sivaraj, AP Kusumbe, A Singh, J Di Russo, MG Bixel, B Zhou, L Sorokin, JM Vaquerizas, RH Adams
    Nat. Cell Biol, 2017-02-20;19(3):189-201.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  36. Basophil-derived IL-6 regulates TH17 cell differentiation and CD4 T cell immunity
    Authors: CM Yuk, HJ Park, BI Kwon, SJ Lah, J Chang, JY Kim, KM Lee, SH Park, S Hong, SH Lee
    Sci Rep, 2017-01-30;7(0):41744.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  37. G-Protein-Coupled Receptor-2-Interacting Protein-1 Controls Stalk Cell Fate by Inhibiting Delta-like 4-Notch1 Signaling
    Cell Rep, 2016-12-06;17(10):2532-2541.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  38. Defective lymphatic valve development and chylothorax in mice with a lymphatic-specific deletion of Connexin43
    Authors: Alexander M Simon
    Dev. Biol., 2016-11-27;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  39. Semaphorin 3G Provides a Repulsive Guidance Cue to Lymphatic Endothelial Cells via Neuropilin-2/PlexinD1
    Cell Rep, 2016-11-22;17(9):2299-2311.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  40. Mechanotransduction activates canonical Wnt/?-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves
    Authors: Boksik Cha
    Genes Dev, 2016-06-16;30(12):1454-69.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  41. Sox7, Sox17, and Sox18 Cooperatively Regulate Vascular Development in the Mouse Retina.
    Authors: Zhou Y, Williams J, Smallwood P, Nathans J
    PLoS ONE, 2015-12-02;10(12):e0143650.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  42. Delayed Healing of Sickle Cell Ulcers Is due to Impaired Angiogenesis and CXCL12 Secretion in Skin Wounds.
    Authors: Nguyen V, Nassar D, Batteux F, Raymond K, Tharaux P, Aractingi S
    J Invest Dermatol, 2015-11-18;136(2):497-506.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  43. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules.
    Authors: Aspelund A, Antila S, Proulx S, Karlsen T, Karaman S, Detmar M, Wiig H, Alitalo K
    J Exp Med, 2015-06-15;212(7):991-9.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  44. Structural and functional features of central nervous system lymphatic vessels.
    Authors: Louveau A, Smirnov I, Keyes T, Eccles J, Rouhani S, Peske J, Derecki N, Castle D, Mandell J, Lee K, Harris T, Kipnis J
    Nature, 2015-06-01;523(7560):337-41.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  45. EphB4 forward signalling regulates lymphatic valve development.
    Authors: Zhang, Gu, Brady, John, Liang, Wei-Chin, Wu, Yan, Henkemeyer, Mark, Yan, Minhong
    Nat Commun, 2015-04-13;6(0):6625.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  46. Quantitative assessment of angiogenesis, perfused blood vessels and endothelial tip cells in the postnatal mouse brain.
    Authors: Walchli T, Mateos J, Weinman O, Babic D, Regli L, Hoerstrup S, Gerhardt H, Schwab M, Vogel J
    Nat Protoc, 2014-12-11;10(1):53-74.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  47. The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel.
    Authors: Aspelund A, Tammela T, Antila S, Nurmi H, Leppanen V, Zarkada G, Stanczuk L, Francois M, Makinen T, Saharinen P, Immonen I, Alitalo K
    J Clin Invest, 2014-07-25;124(9):3975-86.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  48. Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity.
    Authors: Park D, Lee J, Park I, Choi D, Lee S, Song S, Hwang Y, Hong K, Nakaoka Y, Makinen T, Kim P, Alitalo K, Hong Y, Koh G
    J Clin Invest, 2014-07-25;124(9):3960-74.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  49. Schlemm's canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process.
    Authors: Kizhatil, Krishnak, Ryan, Margaret, Marchant, Jeffrey, Henrich, Stephen, John, Simon W
    PLoS Biol, 2014-07-22;12(7):e1001912.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  50. Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions.
    Authors: Zheng W, Nurmi H, Appak S, Sabine A, Bovay E, Korhonen E, Orsenigo F, Lohela M, D'Amico G, Holopainen T, Leow C, Dejana E, Petrova T, Augustin H, Alitalo K
    Genes Dev, 2014-07-15;28(14):1592-603.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  51. Identification of novel genes associated with renal tertiary lymphoid organ formation in aging mice.
    Authors: Huang Y, Caputo C, Noordmans G, Yazdani S, Monteiro L, van den Born J, van Goor H, Heeringa P, Korstanje R, Hillebrands J
    PLoS ONE, 2014-03-17;9(3):e91850.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  52. Endothelial Notch activity promotes angiogenesis and osteogenesis in bone.
    Authors: Ramasamy S, Kusumbe A, Wang L, Adams R
    Nature, 2014-03-12;507(7492):376-80.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  53. Preferential lymphatic growth in bronchus-associated lymphoid tissue in sustained lung inflammation.
    Authors: Baluk P, Adams A, Phillips K, Feng J, Hong Y, Brown M, McDonald D
    Am J Pathol, 2014-03-11;184(5):1577-92.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  54. Molecular identification of venous progenitors in the dorsal aorta reveals an aortic origin for the cardinal vein in mammals.
    Authors: Lindskog, Henrik, Kim, Yung Hae, Jelin, Eric B, Kong, Yupeng, Guevara-Gallardo, Salvador, Kim, Tyson N, Wang, Rong A
    Development, 2014-03-01;141(5):1120-8.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  55. Fusing VE-cadherin to alpha-catenin impairs fetal liver hematopoiesis and lymph but not blood vessel formation.
    Authors: Dartsch N, Schulte D, Hagerling R, Kiefer F, Vestweber D
    Mol Cell Biol, 2014-02-24;34(9):1634-48.
    Species: Mouse
    Sample Types: Embryo, Whole Tissue
    Applications: IHC, IHC-P
  56. Lenalidomide inhibits lymphangiogenesis in preclinical models of mantle cell lymphoma.
    Authors: Song K, Herzog B, Sheng M, Fu J, McDaniel J, Chen H, Ruan J, Xia L
    Cancer Res, 2013-10-24;73(24):7254-64.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  57. A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy.
    Authors: Hagerling R, Pollmann C, Andreas M, Schmidt C, Nurmi H, Adams R, Alitalo K, Andresen V, Schulte-Merker S, Kiefer F
    EMBO J, 2013-01-08;32(5):629-44.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  58. Proteinuria triggers renal lymphangiogenesis prior to the development of interstitial fibrosis.
    Authors: Yazdani S, Poosti F, Kramer A, Mirkovic K, Kwakernaak A, Hovingh M, Slagman M, Sjollema K, de Borst M, Navis G, van Goor H, van den Born J
    PLoS ONE, 2012-11-26;7(11):e50209.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  59. Remodeling of the lymphatic vasculature during mouse mammary gland morphogenesis is mediated via epithelial-derived lymphangiogenic stimuli.
    Authors: Betterman K, Paquet-Fifield S, Asselin-Labat M, Visvader J, Butler L, Stacker S, Achen M, Harvey N
    Am J Pathol, 2012-10-11;181(6):2225-38.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  60. Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling.
    Authors: Benedito R, Rocha S, Woeste M, Zamykal M, Radtke F, Casanovas O, Duarte A, Pytowski B, Adams R
    Nature, 2012-03-18;484(7392):110-4.
    Species: Mouse
    Sample Types: Cell Lysates, Whole Tissue
    Applications: ELISA Development, IHC
  61. Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis.
    Authors: Wang Y, Nakayama M, Pitulescu ME, Schmidt TS, Bochenek ML, Sakakibara A, Adams S, Davy A, Deutsch U, Luthi U, Barberis A, Benjamin LE, Makinen T, Nobes CD, Adams RH
    Nature, 2010-05-27;465(7297):483-6.
    Species: Mouse
    Sample Types: Cell Lysates, Whole Cells, Whole Tissue
    Applications: ICC, IHC-Fr, Immunoprecipitation
  62. Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development.
    Authors: Lin FJ, Chen X, Qin J, Hong YK, Tsai MJ, Tsai SY
    J. Clin. Invest., 2010-04-01;120(5):1694-707.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  63. Vascular endothelial growth factor-C induces lymphangitic carcinomatosis, an extremely aggressive form of lung metastases.
    Authors: Das S, Ladell DS, Podgrabinska S
    Cancer Res., 2010-02-23;70(5):1814-24.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  64. Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3.
    Authors: Xu Y, Yuan L, Mak J, Pardanaud L, Caunt M, Kasman I, Larrivee B, Del Toro R, Suchting S, Medvinsky A, Silva J, Yang J, Thomas JL, Koch AW, Alitalo K, Eichmann A, Bagri A
    J. Cell Biol., 2010-01-11;188(1):115-30.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  65. Transgenic induction of vascular endothelial growth factor-C is strongly angiogenic in mouse embryos but leads to persistent lymphatic hyperplasia in adult tissues.
    Authors: Lohela M, Helotera H, Haiko P, Dumont DJ, Alitalo K
    Am. J. Pathol., 2008-11-06;173(6):1891-901.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC, Immunoprecipitation
  66. Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation.
    Authors: Tammela T, Zarkada G, Wallgard E, Murtomaki A, Suchting S, Wirzenius M, Waltari M, Hellstrom M, Schomber T, Peltonen R, Freitas C, Duarte A, Isoniemi H, Laakkonen P, Christofori G, Yla-Herttuala S, Shibuya M, Pytowski B, Eichmann A, Betsholtz C, Alitalo K
    Nature, 2008-06-25;454(7204):656-60.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  67. Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting.
    Authors: Wirzenius M, Tammela T, Uutela M, He Y, Odorisio T, Zambruno G, Nagy JA, Dvorak HF, Yla-Herttuala S, Shibuya M, Alitalo K
    J. Exp. Med., 2007-05-29;204(6):1431-40.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  68. Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth.
    Authors: Laakkonen P, Waltari M, Holopainen T, Takahashi T, Pytowski B, Steiner P, Hicklin D, Persaud K, Tonra JR, Witte L, Alitalo K
    Cancer Res., 2007-01-15;67(2):593-9.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  69. Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation.
    Authors: Reinhardt RL, Hong S, Kang SJ, Wang ZE, Locksley RM
    J. Immunol., 2006-08-01;177(3):1618-27.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  70. VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain.
    Authors: Le Bras B, Barallobre MJ, Homman-Ludiye J, Ny A, Wyns S, Tammela T, Haiko P, Karkkainen MJ, Yuan L, Muriel MP, Chatzopoulou E, Breant C, Zalc B, Carmeliet P, Alitalo K, Eichmann A, Thomas JL
    Nat. Neurosci., 2006-02-05;9(3):340-8.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  71. Desmoplakin and Plakoglobin--specific markers of lymphatic vessels in the skin?
    Authors: Fedele C, Berens D, Rautenfeld V, Pabst R
    Anat Histol Embryol, 2004-06-01;33(3):168-71.
    Species: Equine
    Sample Types: Whole Tissue
    Applications: IHC
  72. B lymphocyte-specific c-Myc expression stimulates early and functional expansion of the vasculature and lymphatics during lymphomagenesis.
    Authors: Ruddell A, Mezquita P, Brandvold KA, Farr A, Iritani BM
    Am. J. Pathol., 2003-12-01;163(6):2233-45.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC

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Mouse VEGFR3/Flt-4 Antibody
By Justin Vercellino on 11/03/2020
Application: ICC/IF Sample Tested: bone marrow Species: Mouse

Whole-mounted mouse femur
5 ug of Ab used stained for 3 days at room temperature

Immunocytochemistry/Immunofluorescence Mouse VEGFR3/Flt-4 Antibody AF743
Mouse VEGF R3/Flt-4 Antibody
By Anonymous on 08/10/2017
Application: ICC/IF Sample Tested: Adrenal gland tissue Species: Mouse
Immunocytochemistry/Immunofluorescence Mouse VEGF R3/Flt-4 Antibody AF743
Mouse VEGF R3/Flt-4 Antibody
By Anonymous on 10/04/2016
Application: ICC/IF Sample Tested: Mesentery whole mount Species: Mouse

Whole mount immunofluorescence of mouse mesenteric lymphatics. Mesentery was dissected from a P5 neonate, fixed in 2% PFA and stained using AF743 at a 1:200 dilution.

Immunocytochemistry/Immunofluorescence Mouse VEGF R3/Flt-4 Antibody AF743